DK133239C - Analogifremgangsmade til fremstilling af den racemiske eller optisk aktive alfa-(p-(1-cyclohexenyl)-phenyl)-propionsyre eller salte deraf med baser - Google Patents

Analogifremgangsmade til fremstilling af den racemiske eller optisk aktive alfa-(p-(1-cyclohexenyl)-phenyl)-propionsyre eller salte deraf med baser

Info

Publication number
DK133239C
DK133239C DK540069A DK540069A DK133239C DK 133239 C DK133239 C DK 133239C DK 540069 A DK540069 A DK 540069A DK 540069 A DK540069 A DK 540069A DK 133239 C DK133239 C DK 133239C
Authority
DK
Denmark
Prior art keywords
cyclohexenyl
racemic
bases
phenyl
salts
Prior art date
Application number
DK540069A
Other languages
English (en)
Other versions
DK133239B (da
Inventor
A Rossi
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1524068A external-priority patent/CH529086A/de
Priority claimed from CH1656968A external-priority patent/CH559159A5/xx
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK133239B publication Critical patent/DK133239B/da
Application granted granted Critical
Publication of DK133239C publication Critical patent/DK133239C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/38—Alcohols containing six-membered aromatic rings and other rings and having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK540069A 1968-10-11 1969-10-10 Analogifremgangsmade til fremstilling af den racemiske eller optisk aktive alfa-(p-(1-cyclohexenyl)-phenyl)-propionsyre eller salte deraf med baser DK133239C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH1524068A CH529086A (de) 1968-10-11 1968-10-11 Verfahren zur Herstellung neuer a-Phenylcarbonsäuren
CH1656968A CH559159A5 (en) 1968-11-06 1968-11-06 Analgesic anti-inflammatory alpha-phenyl fatty acids
CH708369 1969-05-08
CH1270569 1969-08-21

Publications (2)

Publication Number Publication Date
DK133239B DK133239B (da) 1976-04-12
DK133239C true DK133239C (da) 1976-10-11

Family

ID=27429043

Family Applications (1)

Application Number Title Priority Date Filing Date
DK540069A DK133239C (da) 1968-10-11 1969-10-10 Analogifremgangsmade til fremstilling af den racemiske eller optisk aktive alfa-(p-(1-cyclohexenyl)-phenyl)-propionsyre eller salte deraf med baser

Country Status (12)

Country Link
JP (4) JPS4935615B1 (da)
AT (1) AT299923B (da)
BE (1) BE740099A (da)
CY (1) CY794A (da)
DK (1) DK133239C (da)
FR (1) FR2020394B1 (da)
GB (1) GB1283367A (da)
IE (1) IE33337B1 (da)
MY (1) MY7500090A (da)
NL (1) NL6915401A (da)
OA (1) OA03603A (da)
SE (1) SE372253B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54344U (da) * 1977-06-03 1979-01-05

Also Published As

Publication number Publication date
IE33337B1 (en) 1974-05-29
DE1950054A1 (de) 1970-04-16
JPS4935616B1 (da) 1974-09-25
OA03603A (fr) 1971-03-30
CY794A (en) 1976-12-01
NL6915401A (da) 1970-04-14
JPS4935615B1 (da) 1974-09-25
BE740099A (da) 1970-04-10
AT299923B (de) 1972-07-10
JPS5033055B1 (da) 1975-10-27
GB1283367A (en) 1972-07-26
IE33337L (en) 1970-04-11
MY7500090A (en) 1975-12-31
SE372253B (da) 1974-12-16
DK133239B (da) 1976-04-12
FR2020394A1 (da) 1970-07-10
JPS5033054B1 (da) 1975-10-27
DE1950054B2 (de) 1975-07-10
FR2020394B1 (da) 1974-02-01

Similar Documents

Publication Publication Date Title
DK131728C (da) Analogifremgangsmade til fremstilling af racemiske eller optisk aktive alfa-aminocyclohexadienylalkylen-penicilliner eller-cephalosporiner eller salte deraf
DK120756B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive norscopolaminderivater eller syreadditionssalte eller kvaternære salte heraf.
DK140281B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-phenoxy-2-hydroxy-3-cycloalkylaminopropaner eller syreadditionssalte heraf.
DK136527B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive p-alkoxyfenoxypropanolaminer eller syreadditionssalte deraf.
DK137990C (da) Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 1-arylpropyl-(2)-piperazinderivater eller syreadditionssalte deraf
DK124081B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive piperazinderivater eller syreadditionssalte deraf.
DK132944C (da) Analogifremgangsmade til fremstilling af 4-(4-biphenylyl)-4-oxo-smorsyrer eller estere eller salte heraf
DK125639B (da) Analogifremgangsmåde til fremstilling af racemisk eller optisk aktivt 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylaminopropan eller syreadditionssalte heraf.
DK139582B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive benzocycloheptaisoquinolin-forbindelser eller syreadditionssalte deraf.
DK131988C (da) Analogifremgangsmade til fremstilling af optisk aktive eller racemiske 1-aryloxy-2-hydroxy-3-isopropylamino-propaner ellersyreadditionssalte heraf
DK129235B (da) Fremgangsmåde til fremstilling af racemiske eller optisk aktive quinolinderivater eller syreadditionssalte deraf.
DK133239C (da) Analogifremgangsmade til fremstilling af den racemiske eller optisk aktive alfa-(p-(1-cyclohexenyl)-phenyl)-propionsyre eller salte deraf med baser
DK133980C (da) Analogifremgangsmade til fremstilling af racemiske eller optisk aktive diphenylalkyllactamimidderivater eller syreadditionssalte deraf
DK124477C (da) Analogifremgangsmade til fremstilling af n-(4-(beta-2-methoxy-5-chlor-benzamido-ethyl)-benzensulfonyl)-n'-cyclopentylurinstof eller salte deraf med baser
DK130958B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-phenoxy-2-hydroxy-3-hydroxyalkylaminopropaner eller fysiologisk tålelige syreadditionssalte heraf.
DK133555C (da) Analogifremgangsmade til fremstilling af racemiske eller optisk aktive n-thienylmethyl-heterocycliske forbindelser eller syreadditionssalte deraf
DK135942C (da) Analogifremgangsmade til fremstilling af racemiske eller optisk aktive 1-(m-acyloxyphenyl)-1-hydroxy-2-n-alkylaminoethanereller syreadditionssalte deraf
DK131727C (da) Analogifremgangsmade til fremstilling af oxazinobenzoxaziner eller syreadditionssalte deraf
DK135941C (da) Analogifremgangsmaade til fremstilling af 1-cyclopropyl-1-phenyl-3-amino-1-propanoler eller syreaddittionssalte deraf
DK133005C (da) Analogifremgangsmade til fremstilling af racemisk eller optisk aktiv 1-cyclohexenyl-glycinamidopenicillansyre eller -cephalosporansyrer eller salte deraf
DK131470B (da) Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive thiazolino-pyrimidin-5-on derivater eller syreadditionssalte deraf.
DK132551C (da) Analogifremgangsmade til fremstilling af racemiske eller optisk aktive carbamoylalkoxyphenoxyisopropanolaminderivater eller syreadditionssalte deraf
DK131724C (da) Analogifremgangsmade til fremstilling af bis-(4,7-dihydroxykumarinyl-3)-eddikesyre eller salte heraf med baser
DK132893B (da) Analogifremgangsmade til fremstilling af p-(2-(1-phenyl-3,5-dioxy-4-n-butyl)-pyrazolydinyl)-phenylphosphorsyre eller saltederaf med baser
DK133094C (da) Analogifremgangsmade til fremstilling af racemisk eller optisk aktiv1-(2-nitrilophenoxy)-2-hydroxy-3-isopropylaminopropan eller syreadditionssalte heraf