DK1321471T3 - Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf - Google Patents
Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte herafInfo
- Publication number
- DK1321471T3 DK1321471T3 DK03290605T DK03290605T DK1321471T3 DK 1321471 T3 DK1321471 T3 DK 1321471T3 DK 03290605 T DK03290605 T DK 03290605T DK 03290605 T DK03290605 T DK 03290605T DK 1321471 T3 DK1321471 T3 DK 1321471T3
- Authority
- DK
- Denmark
- Prior art keywords
- perindopril
- pharmaceutically acceptable
- acceptable salts
- synthesis procedure
- new synthesis
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
- 229960002582 perindopril Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03290605A EP1321471B1 (fr) | 2003-03-12 | 2003-03-12 | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1321471T3 true DK1321471T3 (da) | 2005-08-29 |
Family
ID=8185877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03290605T DK1321471T3 (da) | 2003-03-12 | 2003-03-12 | Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf |
Country Status (10)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1367061B1 (fr) | 2003-06-30 | 2006-01-04 | Les Laboratoires Servier | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
| ES2286393T3 (es) * | 2003-06-30 | 2007-12-01 | Les Laboratoires Servier | Nuevo procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables. |
| DK1367062T3 (da) | 2003-07-31 | 2007-01-02 | Servier Lab | Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf |
| ES2252633T3 (es) | 2003-08-29 | 2006-05-16 | Les Laboratoires Servier | Nuevo procedimiento de sintesis de perindopril y de sus bases farmaceuticamente aceptables. |
| SI1380590T1 (sl) * | 2003-08-29 | 2006-12-31 | Servier Lab | Postopek za sintezo perindoprila in njenih farmacevtsko sprejemljivih soli |
| DE602006020760D1 (de) * | 2005-08-12 | 2011-04-28 | Lek Pharmaceuticals | Verfahren zur herstellung von perindoprilerbumin |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| PH12018502155B1 (en) | 2016-04-20 | 2024-03-27 | Servier Lab | Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE55867B1 (en) * | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
| FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
-
2003
- 2003-03-12 ES ES03290605T patent/ES2240919T3/es not_active Expired - Lifetime
- 2003-03-12 DE DE60300581T patent/DE60300581T2/de not_active Expired - Lifetime
- 2003-03-12 AT AT03290605T patent/ATE294814T1/de active
- 2003-03-12 EP EP03290605A patent/EP1321471B1/fr not_active Expired - Lifetime
- 2003-03-12 PT PT03290605T patent/PT1321471E/pt unknown
- 2003-03-12 SI SI200330035T patent/SI1321471T1/xx unknown
- 2003-03-12 DK DK03290605T patent/DK1321471T3/da active
-
2004
- 2004-03-12 MY MYPI20040880A patent/MY135359A/en unknown
- 2004-03-12 WO PCT/FR2004/000594 patent/WO2004083238A1/fr active Application Filing
- 2004-03-12 AR ARP040100804A patent/AR043567A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60300581D1 (de) | 2005-06-09 |
| DE60300581T2 (de) | 2006-01-19 |
| PT1321471E (pt) | 2005-07-29 |
| EP1321471B1 (fr) | 2005-05-04 |
| MY135359A (en) | 2008-03-31 |
| SI1321471T1 (enrdf_load_html_response) | 2005-08-31 |
| ES2240919T3 (es) | 2005-10-16 |
| ATE294814T1 (de) | 2005-05-15 |
| AR043567A1 (es) | 2005-08-03 |
| EP1321471A1 (fr) | 2003-06-25 |
| WO2004083238A1 (fr) | 2004-09-30 |
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