DK1255824T3 - Transgene mus til undersøgelse af neurodegenerative syndromer - Google Patents

Transgene mus til undersøgelse af neurodegenerative syndromer

Info

Publication number
DK1255824T3
DK1255824T3 DK00951857.2T DK00951857T DK1255824T3 DK 1255824 T3 DK1255824 T3 DK 1255824T3 DK 00951857 T DK00951857 T DK 00951857T DK 1255824 T3 DK1255824 T3 DK 1255824T3
Authority
DK
Denmark
Prior art keywords
transgenic
human
animal
antibody
neurodegenerative
Prior art date
Application number
DK00951857.2T
Other languages
English (en)
Inventor
Antonino Cattaneo
Simona Capsoni
Francesca Ruberti
Original Assignee
S I S S A Scuola Internaz Supe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT99MI001783 external-priority patent/IT1313607B1/it
Priority claimed from IT2000RM000306 external-priority patent/IT1317039B1/it
Application filed by S I S S A Scuola Internaz Supe filed Critical S I S S A Scuola Internaz Supe
Application granted granted Critical
Publication of DK1255824T3 publication Critical patent/DK1255824T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK00951857.2T 1999-08-06 2000-07-28 Transgene mus til undersøgelse af neurodegenerative syndromer DK1255824T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT99MI001783 IT1313607B1 (it) 1999-08-06 1999-08-06 Animali transgenici non umani anti-ngf
IT2000RM000306 IT1317039B1 (it) 2000-06-05 2000-06-05 Animali transgenici non umani esprimenti anticorpi anti-ngf.
PCT/IT2000/000321 WO2001010203A2 (en) 1999-08-06 2000-07-28 Non-human transgenic animals for the study of neurodegenerative syndromes

Publications (1)

Publication Number Publication Date
DK1255824T3 true DK1255824T3 (da) 2010-07-19

Family

ID=26331673

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00951857.2T DK1255824T3 (da) 1999-08-06 2000-07-28 Transgene mus til undersøgelse af neurodegenerative syndromer

Country Status (9)

Country Link
US (1) US7273964B1 (da)
EP (1) EP1255824B1 (da)
JP (1) JP2003518922A (da)
AT (1) ATE463567T1 (da)
AU (1) AU783964B2 (da)
CA (1) CA2388341A1 (da)
DE (1) DE60044149D1 (da)
DK (1) DK1255824T3 (da)
WO (1) WO2001010203A2 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005044293A2 (en) * 2003-11-07 2005-05-19 Lay Line Genomics S.P.A. Compositions able to prevent neurodegenerative processes and methods of assaying the same
ITRM20030601A1 (it) 2003-12-24 2005-06-25 Lay Line Genomics Spa Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
ITRM20040212A1 (it) * 2004-04-30 2004-07-30 Lay Line Genomics Spa Animale transgenico non umano come modello per malattie neurodegenerative e per la loro diagnosi precoce.
ITRM20050290A1 (it) 2005-06-07 2006-12-08 Lay Line Genomics Spa Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
PT2448970E (pt) 2009-05-04 2014-10-20 Abbvie Res B V Anticorpos contra factor de crescimento nervoso (ngf) com estabilidade in vivo melhorada
US9200068B2 (en) 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9059991A (en) * 1990-11-13 1992-06-11 Children's Medical Center Corporation Controlling beta-amyloid related neuronal degeneration by antagonizing NGF-effected neuronal activity
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
DE69828574T2 (de) * 1997-11-14 2005-10-06 Sankyo Co., Ltd. Transgenes Tier als Modell für Allergie und seine Verwendung
AU3908299A (en) * 1997-12-08 1999-06-28 Ontogeny, Inc. Cadherin-like polypeptides, methods and compositions related thereto

Also Published As

Publication number Publication date
CA2388341A1 (en) 2001-02-15
US7273964B1 (en) 2007-09-25
ATE463567T1 (de) 2010-04-15
EP1255824A2 (en) 2002-11-13
JP2003518922A (ja) 2003-06-17
EP1255824B1 (en) 2010-04-07
DE60044149D1 (de) 2010-05-20
AU783964B2 (en) 2006-01-05
AU6470000A (en) 2001-03-05
WO2001010203A3 (en) 2002-09-12
WO2001010203A2 (en) 2001-02-15

Similar Documents

Publication Publication Date Title
Mehla et al. Age-dependent behavioral and biochemical characterization of single APP knock-in mouse (APPNL-GF/NL-GF) model of Alzheimer's disease
Steffen et al. Revisiting rodent models: Octodon degus as Alzheimer’s disease model?
Liberski et al. Kuru, the first human prion disease
Finch The biology of human longevity: Inflammation, nutrition, and aging in the evolution of lifespans
Heyser et al. Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
Veenema et al. Early life stress enhances the vulnerability to chronic psychosocial stress and experimental colitis in adult mice
LTC2848258I2 (lt) Šeiminės Viduržemio jūros karštligės gydymas su anti-IL-1 beta antikūnais
Tremml et al. Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified β-amyloid precursor protein gene
Cañete et al. Cognitive and emotional alterations in young Alzheimer's disease (3xTgAD) mice: effects of neonatal handling stimulation and sexual dimorphism
DE69432629D1 (de) Antikörper gegen beta-amyloid oder derivative davon und seine verwendung
DK2306173T3 (da) Apparat og fremgangsmåder til sortering af partikler for at opnå dyresæd, der producerer afkom af et givet køn
DK1976877T3 (da) Monoklonale antistoffer mod amyloid-beta-protein og anvendelser heraf
NO20054078D0 (no) Humane antistoffer spesifikke for Interleukin 15 (IL15).
CN102988417A (zh) 寄生性生物制剂用于疾病预防和控制的用途
Liberski Kuru: a journey back in time from Papua New Guinea to the Neanderthals’ extinction
Guo et al. Modeling Alzheimer’s disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau
IS7811A (is) Aðferðir og prófefni til að meðhöndla sjúkdóma ogkvilla sem tengjast auknu magni af bólguvaldandi frumuboðum
Tripp et al. Mating behavioral function of preoptic galanin neurons is shared between fish with alternative male reproductive tactics and tetrapods
DK1255824T3 (da) Transgene mus til undersøgelse af neurodegenerative syndromer
DE60023451D1 (de) Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper
Huang et al. Neutrophilic inflammation in the immune responses of chronic obstructive pulmonary disease: lessons from animal models
Rabl et al. Quantitative evaluation of orofacial motor function in mice: the pasta gnawing test, a voluntary and stress-free behavior test
Orta-Salazar et al. Primary motor cortex alterations in Alzheimer disease: A study in the 3xTg-AD model
Brasnjevic et al. Region-specific neuron and synapse loss in the hippocampus of APP SL/PS1 knock-in mice
Sherlock et al. Interleukin-23: a promising therapeutic target in seronegative spondyloarthropathy