DK1254122T3 - Novel 3-Substituted 1,2,4-Benzotriazines - Google Patents

Novel 3-Substituted 1,2,4-Benzotriazines

Info

Publication number
DK1254122T3
DK1254122T3 DK00985213T DK00985213T DK1254122T3 DK 1254122 T3 DK1254122 T3 DK 1254122T3 DK 00985213 T DK00985213 T DK 00985213T DK 00985213 T DK00985213 T DK 00985213T DK 1254122 T3 DK1254122 T3 DK 1254122T3
Authority
DK
Denmark
Prior art keywords
substituted
benzotriazines
atoms
novel
group
Prior art date
Application number
DK00985213T
Other languages
Danish (da)
Inventor
Ulrich Stottmeister
Manfred Schoenfelder
Horst Wilde
Dieter Sicker
Jens Andersch
Original Assignee
Ufz Leipzighalle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19963316A external-priority patent/DE19963316A1/en
Application filed by Ufz Leipzighalle Gmbh filed Critical Ufz Leipzighalle Gmbh
Application granted granted Critical
Publication of DK1254122T3 publication Critical patent/DK1254122T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to novel 3-substituted 1,2,4-benzotriazines of the general formula I. In said formula, R<1> represents a straight-chain or branched, saturated, or mono or polyunsaturated, unsubstituted hydrocarbon group with 1 to 22 atoms, or a hydrocarbon group with 1 to 22 atoms, substituted once or several times by halogen, oxygen, hydroxy, amino, alkoxy, alkoxycarbonyl, morpholino and/or alkyl amino, or an unsubstituted or substituted aryl group or a heterocyclic group. R<2>. R<3>, R<4> and R<5> are identical or represent independently of one another hydrogen, halogen, NO2, NH2, OH or an alkoxy or alkyl group with 1-6 atoms. The invention also relates to a method for producing said 3-substituted 1,2,4-benzotriazines and to the use thereof for treating tumours.
DK00985213T 1999-12-21 2000-12-20 Novel 3-Substituted 1,2,4-Benzotriazines DK1254122T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19963316A DE19963316A1 (en) 1999-12-21 1999-12-21 New hydrocarbyl-, aryl- or heterocyclyl-substituted 1,2,4-benzotriazine derivatives, useful for the treatment and prevention of tumors
US21575600P 2000-06-30 2000-06-30
PCT/EP2000/013028 WO2001046162A2 (en) 1999-12-21 2000-12-20 Novel 3-substituted 1,2,4-benzotriazines, a method for their production and the use thereof for the treatment and prophylaxis of tumours

Publications (1)

Publication Number Publication Date
DK1254122T3 true DK1254122T3 (en) 2009-01-12

Family

ID=26055919

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00985213T DK1254122T3 (en) 1999-12-21 2000-12-20 Novel 3-Substituted 1,2,4-Benzotriazines

Country Status (7)

Country Link
EP (1) EP1254122B1 (en)
AT (1) ATE408606T1 (en)
AU (1) AU2169301A (en)
DE (1) DE50015366D1 (en)
DK (1) DK1254122T3 (en)
ES (1) ES2315245T3 (en)
WO (1) WO2001046162A2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD150463A1 (en) * 1978-10-19 1981-09-02 Horst Wilde PROCESS FOR THE PREPARATION OF BENZO-1.2.4-TRIAZIN-3-YLESSIGSAE DERIVATIVES
DD278791A1 (en) * 1988-12-27 1990-05-16 Univ Leipzig PROCESS FOR THE PREPARATION OF NEW 6-AMINOBENZO-1,2,4-TRIAZIN-3-YL-ESSIGSAEED DERIVATIVES
US5484612A (en) * 1993-09-22 1996-01-16 The Board Of Trustees Of The Leland Stanford Junior University Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin

Also Published As

Publication number Publication date
WO2001046162A3 (en) 2002-04-18
EP1254122B1 (en) 2008-09-17
AU2169301A (en) 2001-07-03
ATE408606T1 (en) 2008-10-15
WO2001046162A2 (en) 2001-06-28
EP1254122A2 (en) 2002-11-06
DE50015366D1 (en) 2008-10-30
ES2315245T3 (en) 2009-04-01

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