AU2169301A - Novel 3-substituted 1,2,4-benzotriazines, a method for their production and the use thereof - Google Patents

Novel 3-substituted 1,2,4-benzotriazines, a method for their production and the use thereof

Info

Publication number
AU2169301A
AU2169301A AU21693/01A AU2169301A AU2169301A AU 2169301 A AU2169301 A AU 2169301A AU 21693/01 A AU21693/01 A AU 21693/01A AU 2169301 A AU2169301 A AU 2169301A AU 2169301 A AU2169301 A AU 2169301A
Authority
AU
Australia
Prior art keywords
substituted
benzotriazines
atoms
novel
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU21693/01A
Inventor
Jens Andersch
Manfred Schonfelder
Dieter Sicker
Ulrich Stottmeister
Horst Wilde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum fuer Umweltforschung GmbH UFZ
Original Assignee
Helmholtz Zentrum fuer Umweltforschung GmbH UFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19963316A external-priority patent/DE19963316A1/en
Application filed by Helmholtz Zentrum fuer Umweltforschung GmbH UFZ filed Critical Helmholtz Zentrum fuer Umweltforschung GmbH UFZ
Publication of AU2169301A publication Critical patent/AU2169301A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to novel 3-substituted 1,2,4-benzotriazines of the general formula I. In said formula, R<1> represents a straight-chain or branched, saturated, or mono or polyunsaturated, unsubstituted hydrocarbon group with 1 to 22 atoms, or a hydrocarbon group with 1 to 22 atoms, substituted once or several times by halogen, oxygen, hydroxy, amino, alkoxy, alkoxycarbonyl, morpholino and/or alkyl amino, or an unsubstituted or substituted aryl group or a heterocyclic group. R<2>. R<3>, R<4> and R<5> are identical or represent independently of one another hydrogen, halogen, NO2, NH2, OH or an alkoxy or alkyl group with 1-6 atoms. The invention also relates to a method for producing said 3-substituted 1,2,4-benzotriazines and to the use thereof for treating tumours.
AU21693/01A 1999-12-21 2000-12-20 Novel 3-substituted 1,2,4-benzotriazines, a method for their production and the use thereof Abandoned AU2169301A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19963316 1999-12-21
DE19963316A DE19963316A1 (en) 1999-12-21 1999-12-21 New hydrocarbyl-, aryl- or heterocyclyl-substituted 1,2,4-benzotriazine derivatives, useful for the treatment and prevention of tumors
US21575600P 2000-06-30 2000-06-30
US60215756 2000-06-30
PCT/EP2000/013028 WO2001046162A2 (en) 1999-12-21 2000-12-20 Novel 3-substituted 1,2,4-benzotriazines, a method for their production and the use thereof for the treatment and prophylaxis of tumours

Publications (1)

Publication Number Publication Date
AU2169301A true AU2169301A (en) 2001-07-03

Family

ID=26055919

Family Applications (1)

Application Number Title Priority Date Filing Date
AU21693/01A Abandoned AU2169301A (en) 1999-12-21 2000-12-20 Novel 3-substituted 1,2,4-benzotriazines, a method for their production and the use thereof

Country Status (7)

Country Link
EP (1) EP1254122B1 (en)
AT (1) ATE408606T1 (en)
AU (1) AU2169301A (en)
DE (1) DE50015366D1 (en)
DK (1) DK1254122T3 (en)
ES (1) ES2315245T3 (en)
WO (1) WO2001046162A2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD150463A1 (en) * 1978-10-19 1981-09-02 Horst Wilde PROCESS FOR THE PREPARATION OF BENZO-1.2.4-TRIAZIN-3-YLESSIGSAE DERIVATIVES
DD278791A1 (en) * 1988-12-27 1990-05-16 Univ Leipzig PROCESS FOR THE PREPARATION OF NEW 6-AMINOBENZO-1,2,4-TRIAZIN-3-YL-ESSIGSAEED DERIVATIVES
US5484612A (en) 1993-09-22 1996-01-16 The Board Of Trustees Of The Leland Stanford Junior University Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin

Also Published As

Publication number Publication date
ATE408606T1 (en) 2008-10-15
WO2001046162A3 (en) 2002-04-18
ES2315245T3 (en) 2009-04-01
DE50015366D1 (en) 2008-10-30
EP1254122A2 (en) 2002-11-06
EP1254122B1 (en) 2008-09-17
DK1254122T3 (en) 2009-01-12
WO2001046162A2 (en) 2001-06-28

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase