DK123018B - Analogifremgangsmåde til fremstilling af α-(1-aralkyliden-indenyl-3 eller -indanyl-3)-alifatiske syrer eller salte, amider eller estere deraf. - Google Patents

Analogifremgangsmåde til fremstilling af α-(1-aralkyliden-indenyl-3 eller -indanyl-3)-alifatiske syrer eller salte, amider eller estere deraf.

Info

Publication number
DK123018B
DK123018B DK267763AA DK267763A DK123018B DK 123018 B DK123018 B DK 123018B DK 267763A A DK267763A A DK 267763AA DK 267763 A DK267763 A DK 267763A DK 123018 B DK123018 B DK 123018B
Authority
DK
Denmark
Prior art keywords
aralkylidene
indanyl
indenyl
amides
esters
Prior art date
Application number
DK267763AA
Other languages
English (en)
Inventor
T Shen
C Winter
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK123018B publication Critical patent/DK123018B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/48—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/337—Polycyclic acids with carboxyl groups bound to condensed ring systems
    • C07C63/34—Polycyclic acids with carboxyl groups bound to condensed ring systems containing two condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
    • C07C63/74—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)
DK267763AA 1962-06-06 1963-06-06 Analogifremgangsmåde til fremstilling af α-(1-aralkyliden-indenyl-3 eller -indanyl-3)-alifatiske syrer eller salte, amider eller estere deraf. DK123018B (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20035062A 1962-06-06 1962-06-06
US278390A US3325358A (en) 1962-06-06 1963-05-06 Method of treating inflammation
US498181A US3312730A (en) 1962-06-06 1965-09-14 Indenyl acids and derivatives thereof

Publications (1)

Publication Number Publication Date
DK123018B true DK123018B (da) 1972-05-08

Family

ID=27394147

Family Applications (1)

Application Number Title Priority Date Filing Date
DK267763AA DK123018B (da) 1962-06-06 1963-06-06 Analogifremgangsmåde til fremstilling af α-(1-aralkyliden-indenyl-3 eller -indanyl-3)-alifatiske syrer eller salte, amider eller estere deraf.

Country Status (9)

Country Link
US (2) US3325358A (da)
CH (1) CH461469A (da)
DE (1) DE1468261A1 (da)
DK (1) DK123018B (da)
FI (1) FI42078B (da)
FR (1) FR1552755A (da)
GB (1) GB1038725A (da)
NO (1) NO121444B (da)
SE (1) SE333369B (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE656652A (da) * 1963-12-05
US3483227A (en) * 1966-06-03 1969-12-09 Merck & Co Inc 2,5 - disubstituted - 2 - (carboxyalkoxyaroyl) - 6 - (carboxyalkoxyaryl)-3,4-dihydro-2h-pyrans and their derivatives
JPS5121981B1 (da) * 1967-09-11 1976-07-06
US3888902A (en) * 1972-10-30 1975-06-10 Merck & Co Inc Cyano-indenyl acetic acids
BE754556A (fr) * 1969-08-08 1971-02-08 Merck & Co Inc Acides indenyl-acetiques et procede pour les
US3956363A (en) * 1969-08-08 1976-05-11 Merck & Co., Inc. Substituted indenyl acetic acids
US3696122A (en) * 1970-04-13 1972-10-03 Riker Laboratories Inc Thiophene derivatives
US3725548A (en) * 1970-05-01 1973-04-03 Merck & Co Inc Substituted indenyl acetic acids in the treatment of pain, fever or inflammation
US3882239A (en) * 1972-09-06 1975-05-06 Merck & Co Inc Method of treating pain fever and inflammation and composition
US4087549A (en) * 1972-12-06 1978-05-02 Merck & Co., Inc. Sulphonic acid containing indenyl derivatives
JPS5623982B2 (da) * 1972-12-07 1981-06-03
US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
US4007225A (en) * 1973-08-11 1977-02-08 Takeda Chemical Industries, Ltd. 4-Benzoylindan-1-carboxamide and derivatives thereof
US3869507A (en) * 1973-10-03 1975-03-04 Merck & Co Inc Preparation of 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indenyl-3-acetic acid
US3897487A (en) * 1973-10-03 1975-07-29 Merck & Co Inc Preparation of 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene) indenyl-3-acetic acid
US3868415A (en) * 1973-10-03 1975-02-25 Merck & Co Inc Preparation of 5-fluoro-2-methyl-1-(p-methyl-sulfinylbenzylidene)-indenyl-3-acetic acid
US3954852A (en) * 1973-10-19 1976-05-04 Merck & Co., Inc. Indenylacetic acid compounds
US4038274A (en) * 1975-07-28 1977-07-26 E. R. Squibb & Sons, Inc. Cns active compounds
US4189598A (en) * 1978-07-24 1980-02-19 Zoecon Corporation Phenoxybenzyl 2-[2-(2-hydroxy)indanyl]-3-methyl-butanoates
GR74444B (da) * 1980-03-21 1984-06-28 Merck & Co Inc
US4656190A (en) * 1983-11-14 1987-04-07 Merck & Co., Inc. Indene derivatives and their use as PAF-antagonists
US5093356A (en) * 1990-01-16 1992-03-03 Merck Frosst Canada, Inc. Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
MY113062A (en) * 1994-05-10 2001-11-30 The Wellcome Foundation Ltd Amide derivatives and their therapeutic use
ES2135065T3 (es) * 1994-05-10 1999-10-16 Wellcome Found Derivados de amida y su uso terapeutico.
US6063818A (en) * 1996-06-13 2000-05-16 Cell Pathways Inc. Substituted benzylidene indenyl formamides, acetamides and propionamides
US5965619A (en) * 1996-06-13 1999-10-12 Cell Pathways Inc. Method for treating patients having precancerous lesions with substituted indene derivatives
US5998477A (en) * 1996-06-13 1999-12-07 Cell Pathways Inc. Substituted methoxy benzylidene indenyl-acetic and propionic acids for treating patients with precancerous lesions
US6121321A (en) * 1996-06-13 2000-09-19 Cell Pathways, Inc. Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions
US5948779A (en) * 1997-12-12 1999-09-07 Cell Pathways, Inc. Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes
US6028116A (en) * 1998-04-03 2000-02-22 Cell Pathways, Inc. Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia
US20030073711A1 (en) * 2001-08-23 2003-04-17 Whitehead Clark M. Methods for treatment of scleroderma
US6479493B1 (en) 2001-08-23 2002-11-12 Cell Pathways, Inc. Methods for treatment of type I diabetes
US20030073740A1 (en) * 2001-08-23 2003-04-17 Whitehead Clark M. Methods for treatment of lupus erythematosus
CA2628856A1 (en) * 2005-11-08 2007-05-18 Jordi Frigola-Constansa Indene derivatives, their preparation and use as medicaments
WO2008149181A1 (en) 2007-06-04 2008-12-11 Techfields Inc Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses
US9862698B2 (en) * 2014-12-16 2018-01-09 Adt Pharmaceuticals, Inc. Indenyl compounds, pharmaceutical compositions, and medical uses thereof
JP6153264B2 (ja) * 2015-01-05 2017-06-28 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
JP6621775B2 (ja) * 2017-03-22 2019-12-18 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
CA3096700C (en) 2018-04-26 2023-08-22 Adt Pharmaceuticals, Llc Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses
JP2020147604A (ja) * 2020-06-17 2020-09-17 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2954400A (en) * 1958-04-09 1960-09-27 Us Vitamin Pharm Corp alpha-indanoxybutyric acid derivatives
US3080419A (en) * 1958-12-29 1963-03-05 Rhone Poulenc Sa 1-methyl-3-phenylindene-1-carboxylic acid
US3047462A (en) * 1959-03-06 1962-07-31 Lab Jacques Logeais Soc D Expl Quinazolone anti-inflammatory composition
US3009858A (en) * 1959-05-04 1961-11-21 Ercoli Alberto 3-(beta-haloethyl) enolether of cortisone acetate
US3121740A (en) * 1961-06-30 1964-02-18 Sterling Drug Inc 4-(hydroxy-and alkoxy-)-7-indanoyl-alkanoic acids
US3114768A (en) * 1961-09-25 1963-12-17 Union Carbide Corp Synthesis of polycyclic alkanoic acid compounds

Also Published As

Publication number Publication date
DE1468261A1 (de) 1968-12-05
US3312730A (en) 1967-04-04
FI42078B (da) 1970-02-02
US3325358A (en) 1967-06-13
SE333369B (da) 1971-03-15
FR1552755A (da) 1969-01-10
GB1038725A (en) 1966-08-10
CH461469A (de) 1968-08-31
NO121444B (da) 1971-03-01

Similar Documents

Publication Publication Date Title
DK123018B (da) Analogifremgangsmåde til fremstilling af α-(1-aralkyliden-indenyl-3 eller -indanyl-3)-alifatiske syrer eller salte, amider eller estere deraf.
DK113364B (da) Fremgangsmåde til fremstilling af 6,7-methylendioxy-4-oxo-3-quinolincarboxylsyrer eller alkalimetalsalte deraf.
DK123871B (da) Analogifremgangmåde til fremstilling af α-amino-α-(hydroxyphenyl)-methylpenicillansyrer eller salte deraf.
DK120903B (da) Analogifremgangsmåde til fremstilling af (α-phenoxy)-substituerede carboxylsyrer eller salte, estere og amider deraf.
DK128005B (da) Analogifremgangsmåde til fremstilling af bis-chromoner eller salte, amider eller estere deraf.
DK131907B (da) Fremgangsmåde til fremstilling af en alfa-aminobenzylpenicillin eller salte deraf.
DK129162B (da) Analogifremgangsmåde til fremstilling af 4-oxo-4H-1-benzopyran-2-carboxylsyrer eller salte, estere eller amider deraf.
DK117571B (da) Fremgangsmåde til fremstilling af basiske estre eller salte deraf.
DK127879B (da) Analogifremgangsmåde til fremstilling af 5β-taurocholen- eller 5β-taurocholadiensyrer eller salte, estere eller amider deraf.
DK114840B (da) Fremgangsmåde til fremstilling af diaralkylaminer eller syreadditionssalte heraf.
DK140639B (da) Fremgangsmåde til fremstilling af 7beta-acylamino-3-methyl-ceph-3-em-4-carboxylsyrer eller salte, estere eller amider heraf.
DK119063B (da) Fremgangsmåde til fremstilling af alkanolaminestere eller salte deraf.
DK111894B (da) Fremgangsmåde til fremstilling af diphenylalkylaminer eller syreadditionssalte deraf.
DK134548B (da) Analogifremgangsmåde til fremstilling af sulfamyl-m-aminobenzoesyrer eller salte, estre eller amider deraf.
DK118290B (da) Analogifremgangsmåde til fremstilling af basisk substituerede naphthalen-(1,4,5,8)-tetracarboxylsyre-diimider eller salte deraf.
DK106858C (da) Fremgangsmåde til fremstilling af N-acyl-N-hydroxyaminoaliphatiske syrer eller derivater eller salte heraf.
DK103564C (da) Fremgangsmåde til fremstilling af trihydroxamsyrer eller salte eller O-acylderivater deraf.
DK105981C (da) Fremgangsmåde til fremstilling af derivater af fusidinsyre eller dihydrofusidinsyre eller salte heraf.
DK107876C (da) Fremgangsmåde til fremstilling af phenylethanolaminer eller salte heraf.
DK111143B (da) Fremgangsmåde til fremstilling af sulfamylanthranilsyrer.
DK113080B (da) Fremgangsmåde til fremstilling af monophosphorsyreesteren af hexachlorophen eller salte heraf.
DK104678C (da) Fremgangsmåde til fremstilling af phenyl-pyrimidylamino-hydroxyalkaner eller estere eller salte heraf.
DK124254B (da) Analogifremgangsmåde til fremstilling af α-aminocarboxylsyreestere, eller syreadditionssalte deraf.
DK116213B (da) Fremgangsmåde til fremstilling af dibenzocycloheptenylestre eller syreadditionssalte heraf.
DK113577B (da) Fremgangsmåde til fremstilling af benzensulfonyl-semicarbazider eller salte deraf.