DK117225B - Fremgangsmåde til fremstilling af mono- eller di-N-bis-(β-klor- eller bromætyl)-karbamidsyreestere af østran-, androstan- eller pregnanforbindelser. - Google Patents
Fremgangsmåde til fremstilling af mono- eller di-N-bis-(β-klor- eller bromætyl)-karbamidsyreestere af østran-, androstan- eller pregnanforbindelser.Info
- Publication number
- DK117225B DK117225B DK173064AA DK173064A DK117225B DK 117225 B DK117225 B DK 117225B DK 173064A A DK173064A A DK 173064AA DK 173064 A DK173064 A DK 173064A DK 117225 B DK117225 B DK 117225B
- Authority
- DK
- Denmark
- Prior art keywords
- estrane
- androstane
- bromoethyl
- chloro
- mono
- Prior art date
Links
- QZLYKIGBANMMBK-UGCZWRCOSA-N 5α-Androstane Chemical compound C([C@@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 QZLYKIGBANMMBK-UGCZWRCOSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 125000005998 bromoethyl group Chemical group 0.000 title 1
- 239000004202 carbamide Substances 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- GRXPVLPQNMUNNX-MHJRRCNVSA-N estrane Chemical compound C1CC2CCCC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 GRXPVLPQNMUNNX-MHJRRCNVSA-N 0.000 title 1
- 150000003128 pregnanes Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C19/00—Apparatus specially adapted for applying particulate materials to surfaces
- B05C19/02—Apparatus specially adapted for applying particulate materials to surfaces using fluidised-bed techniques
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Paints Or Removers (AREA)
- Glass Compositions (AREA)
- Curing Cements, Concrete, And Artificial Stone (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB14160/63A GB1016959A (en) | 1963-04-09 | 1963-04-09 | Substituted steroid hormones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK117225B true DK117225B (da) | 1970-03-31 |
Family
ID=10036092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK173064AA DK117225B (da) | 1963-04-09 | 1964-04-08 | Fremgangsmåde til fremstilling af mono- eller di-N-bis-(β-klor- eller bromætyl)-karbamidsyreestere af østran-, androstan- eller pregnanforbindelser. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US3299104A (cs) |
| BE (1) | BE646319A (cs) |
| BR (1) | BR6458190D0 (cs) |
| CH (1) | CH452514A (cs) |
| DK (1) | DK117225B (cs) |
| ES (1) | ES298429A1 (cs) |
| FI (1) | FI41742B (cs) |
| FR (1) | FR3331M (cs) |
| NO (1) | NO123943B (cs) |
| SE (1) | SE314977B (cs) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3499158A (en) * | 1964-04-24 | 1970-03-03 | Raytheon Co | Circuits utilizing the threshold properties of recombination radiation semiconductor devices |
| GB1523035A (en) | 1976-03-10 | 1978-08-31 | Leo Ab | Derivatives of estradiol - 17 - dihydrogen phosphates |
| EP0105404A1 (en) * | 1982-09-30 | 1984-04-18 | Merck & Co. Inc. | Derivatives of steroid compounds linked to cyotoxic agents and process for their preparation |
| SE8802402D0 (sv) * | 1988-06-28 | 1988-06-28 | Pharmacia Ab | Novel esters |
| US5041434A (en) * | 1991-08-17 | 1991-08-20 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
| JP2554005B2 (ja) * | 1993-02-18 | 1996-11-13 | 株式会社パーマケム・アジア | エストラムスチンフォスフェート又はその塩類の精製方法 |
| US5882941A (en) * | 1994-05-04 | 1999-03-16 | Massachusette Institute Of Technology | Programmable genotoxic agents and uses therefor |
| US6500669B1 (en) * | 1994-05-04 | 2002-12-31 | Massachusetts Institute Of Technology | Programmable genotoxic agents and uses therefor |
| GB9419153D0 (en) * | 1994-09-22 | 1994-11-09 | Erba Carlo Spa | Estramustine formulations with improved pharmaceutical properties |
| US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
| WO2014168986A1 (en) | 2013-04-08 | 2014-10-16 | Brown Dennis M | Therapeutic benefit of suboptimally administered chemical compounds |
| BR112016017993A2 (pt) | 2014-02-03 | 2017-08-08 | Quadriga Biosciences Inc | Gama-aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos |
| NZ723940A (en) | 2014-02-03 | 2017-12-22 | Quadriga Biosciences Inc | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents |
| WO2017024009A1 (en) | 2015-08-03 | 2017-02-09 | Quadriga Biosciences, Inc. | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2885413A (en) * | 1956-12-17 | 1959-05-05 | Upjohn Co | 11-oxygenated estradiol compounds and derivatives |
| US3081298A (en) * | 1959-08-28 | 1963-03-12 | Ciba Geigy Corp | New cyclohemiacetals and cyclohemiacetal esters of the pregnane series and a processfor their manufacture |
-
1964
- 1964-04-01 US US356666A patent/US3299104A/en not_active Expired - Lifetime
- 1964-04-07 BR BR158190/64A patent/BR6458190D0/pt unknown
- 1964-04-08 DK DK173064AA patent/DK117225B/da unknown
- 1964-04-08 ES ES0298429A patent/ES298429A1/es not_active Expired
- 1964-04-08 CH CH442864A patent/CH452514A/de unknown
- 1964-04-09 BE BE646319A patent/BE646319A/xx unknown
- 1964-04-09 FR FR970258A patent/FR3331M/fr not_active Expired
- 1964-04-09 NO NO152768A patent/NO123943B/no unknown
- 1964-04-09 FI FI0747/64A patent/FI41742B/fi active
- 1964-04-09 SE SE4376/64A patent/SE314977B/xx unknown
-
1976
- 1976-07-30 US US05/708,921 patent/USRE29199E/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FI41742B (cs) | 1969-10-31 |
| NO123943B (cs) | 1972-02-07 |
| US3299104A (en) | 1967-01-17 |
| FR3331M (fr) | 1965-05-24 |
| BE646319A (cs) | 1964-07-31 |
| CH452514A (de) | 1968-03-15 |
| SE314977B (cs) | 1969-09-22 |
| ES298429A1 (es) | 1964-10-16 |
| BR6458190D0 (pt) | 1973-12-26 |
| USRE29199E (en) | 1977-05-03 |
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