DK1140929T3 - 1 H-Imidazo[4,5-d]pyridazin-7-oner, 3H-imidazo[4,5-c]pyridin-4-oner og tilsvarende thioner som corticotropinfrigivende faktor (CRF)-receptorligander - Google Patents

1 H-Imidazo[4,5-d]pyridazin-7-oner, 3H-imidazo[4,5-c]pyridin-4-oner og tilsvarende thioner som corticotropinfrigivende faktor (CRF)-receptorligander

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Publication number
DK1140929T3
DK1140929T3 DK99966736T DK99966736T DK1140929T3 DK 1140929 T3 DK1140929 T3 DK 1140929T3 DK 99966736 T DK99966736 T DK 99966736T DK 99966736 T DK99966736 T DK 99966736T DK 1140929 T3 DK1140929 T3 DK 1140929T3
Authority
DK
Denmark
Prior art keywords
imidazo
ones
crf
releasing factor
thions
Prior art date
Application number
DK99966736T
Other languages
English (en)
Inventor
Paul Joseph Gilligan
Rajagopal Bakthavatchalam
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Application granted granted Critical
Publication of DK1140929T3 publication Critical patent/DK1140929T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK99966736T 1998-12-30 1999-12-30 1 H-Imidazo[4,5-d]pyridazin-7-oner, 3H-imidazo[4,5-c]pyridin-4-oner og tilsvarende thioner som corticotropinfrigivende faktor (CRF)-receptorligander DK1140929T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11418898P 1998-12-30 1998-12-30
PCT/US1999/031325 WO2000039127A1 (en) 1998-12-30 1999-12-30 1h-imidazo[4,5-d]pyridazin-7-ones, 3h-imidazo[4,5-c]pyridin-4-ones and corresponding thiones as corticotropin releasing factor (crf) receptor ligands

Publications (1)

Publication Number Publication Date
DK1140929T3 true DK1140929T3 (da) 2004-02-16

Family

ID=22353834

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99966736T DK1140929T3 (da) 1998-12-30 1999-12-30 1 H-Imidazo[4,5-d]pyridazin-7-oner, 3H-imidazo[4,5-c]pyridin-4-oner og tilsvarende thioner som corticotropinfrigivende faktor (CRF)-receptorligander

Country Status (10)

Country Link
US (2) US6271380B1 (da)
EP (1) EP1140929B1 (da)
AT (1) ATE251930T1 (da)
AU (1) AU2222500A (da)
CA (1) CA2351724A1 (da)
DE (1) DE69912153T2 (da)
DK (1) DK1140929T3 (da)
ES (1) ES2209550T3 (da)
PT (1) PT1140929E (da)
WO (1) WO2000039127A1 (da)

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DE19837387A1 (de) * 1998-08-18 2000-02-24 Aventis Res & Tech Gmbh & Co 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung
RU2003126188A (ru) 2001-01-26 2005-03-27 Бристол-Маерс Сквибб Компани (Us) Имидазолильные производные как ингибиторы кортикотропин-рилизинг фактора
TWI312347B (en) 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
CA2443802C (en) 2001-04-27 2010-04-13 Eisai Co., Ltd. Pyrazolo[1,5-a]pyridines and medicines containing the same
CA2478715A1 (en) 2002-03-13 2003-09-25 Pharmacia & Upjohn Company Novel pyrazolo [1,5-a]pyridine derivatives and their use as neurotransmitter modulators
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US7176216B2 (en) 2002-10-22 2007-02-13 Eisai Co., Ltd. 7-phenylpyrazolopyridine compounds
EP1555265B1 (en) 2002-10-22 2009-03-25 Eisai R&D Management Co., Ltd. 7-phenyl pyrazolopyridine compounds
EP1706403B9 (en) 2003-12-22 2012-07-25 K.U.Leuven Research & Development Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
ATE421518T1 (de) * 2005-02-10 2009-02-15 Bristol Myers Squibb Co Dihydrochinazolinone als 5ht-modulatoren
BRPI0614485A2 (pt) * 2005-07-28 2011-03-29 Bristol-Myers Squibb Company tetrahidro-1h-pirido [4, 3, b] indóis substituìdos como agonistas e antagonistas receptores de serotonina
US7795436B2 (en) * 2005-08-24 2010-09-14 Bristol-Myers Squibb Company Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
CA2721670C (en) 2008-04-15 2013-09-10 Eisai R&D Management Co., Ltd. 3-phenylpyrazolo[5,1-b]thiazole compound
AR078521A1 (es) 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
WO2013097052A1 (en) * 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
WO2014206150A1 (en) * 2013-06-28 2014-12-31 Abbvie Inc. Bromodomain inhibitors
AR096758A1 (es) * 2013-06-28 2016-02-03 Abbvie Inc Inhibidores cristalinos de bromodominios
AU2014363989A1 (en) * 2013-12-09 2016-06-16 Abbvie Inc. Dihydropyridinone and dihydropyridazinone derivatives useful as bromodomain inhibitors
TWI764237B (zh) 2016-04-15 2022-05-11 美商艾伯維有限公司 溴域抑制劑

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WO1991019715A1 (en) * 1990-06-15 1991-12-26 G.D. Searle & Co. 1H-SUBSTITUTED-IMIDAZO[4,5-d]PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS
JP3398152B2 (ja) 1993-10-12 2003-04-21 ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体
US5968944A (en) 1994-06-06 1999-10-19 Pfizer Inc. Substituted pyrazoles as corticotropin-releasing factor (CRF) antagonists
TW530047B (en) 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
JP2891544B2 (ja) 1994-06-16 1999-05-17 ファイザー・インコーポレーテッド ピラゾロおよびピロロピリジン類
EP0778277B1 (en) 1995-12-08 2003-06-25 Pfizer Inc. Substituted heterocyclic derivatives as CRF antagonists
JP2001511813A (ja) * 1997-02-18 2001-08-14 ニューロクライン バイオサイエンシーズ，インコーポレイテッド Ｃｒｆレセプターアンタゴニストおよびそれらに関連する方法
AU746706B2 (en) * 1997-07-03 2002-05-02 Du Pont Pharmaceuticals Company Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists

Also Published As

Publication number Publication date
EP1140929A4 (en) 2002-04-17
ATE251930T1 (de) 2003-11-15
WO2000039127A1 (en) 2000-07-06
DE69912153T2 (de) 2004-08-26
EP1140929A1 (en) 2001-10-10
US6518271B1 (en) 2003-02-11
EP1140929B1 (en) 2003-10-15
CA2351724A1 (en) 2000-07-06
AU2222500A (en) 2000-07-31
PT1140929E (pt) 2004-02-27
DE69912153D1 (de) 2003-11-20
ES2209550T3 (es) 2004-06-16
US6271380B1 (en) 2001-08-07

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