DK113083A - Fremgangsmaade til fremstilling af et antistofkonjugat - Google Patents

Fremgangsmaade til fremstilling af et antistofkonjugat Download PDF

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Publication number
DK113083A
DK113083A DK113083A DK113083A DK113083A DK 113083 A DK113083 A DK 113083A DK 113083 A DK113083 A DK 113083A DK 113083 A DK113083 A DK 113083A DK 113083 A DK113083 A DK 113083A
Authority
DK
Denmark
Prior art keywords
preparing
procedure
antibody conjugate
conjugate
antibody
Prior art date
Application number
DK113083A
Other languages
Danish (da)
English (en)
Other versions
DK113083D0 (da
Inventor
Thomas Joseph Mckearn
John Dennis Rodwell
John Walter Frank Goers
Chyi Lee
Original Assignee
Cytogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/356,315 external-priority patent/US4671958A/en
Application filed by Cytogen Corp filed Critical Cytogen Corp
Publication of DK113083D0 publication Critical patent/DK113083D0/da
Publication of DK113083A publication Critical patent/DK113083A/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
DK113083A 1982-03-09 1983-03-08 Fremgangsmaade til fremstilling af et antistofkonjugat DK113083A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/356,315 US4671958A (en) 1982-03-09 1982-03-09 Antibody conjugates for the delivery of compounds to target sites
US44205082A 1982-11-16 1982-11-16

Publications (2)

Publication Number Publication Date
DK113083D0 DK113083D0 (da) 1983-03-08
DK113083A true DK113083A (da) 1983-09-10

Family

ID=26999177

Family Applications (1)

Application Number Title Priority Date Filing Date
DK113083A DK113083A (da) 1982-03-09 1983-03-08 Fremgangsmaade til fremstilling af et antistofkonjugat

Country Status (7)

Country Link
EP (1) EP0088695B1 (el)
JP (3) JPH0788310B2 (el)
AU (1) AU556446B2 (el)
CA (1) CA1203164A (el)
DE (1) DE3382572T2 (el)
DK (1) DK113083A (el)
GR (1) GR77424B (el)

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Also Published As

Publication number Publication date
JPH06234660A (ja) 1994-08-23
CA1203164A (en) 1986-04-15
EP0088695A3 (en) 1986-01-29
JPH0788310B2 (ja) 1995-09-27
AU556446B2 (en) 1986-11-06
EP0088695A2 (en) 1983-09-14
JP2503319B2 (ja) 1996-06-05
JPS58222035A (ja) 1983-12-23
AU1199083A (en) 1983-09-15
DE3382572T2 (de) 1993-01-14
JPH06256216A (ja) 1994-09-13
DE3382572D1 (de) 1992-07-09
GR77424B (el) 1984-09-14
JP2503334B2 (ja) 1996-06-05
EP0088695B1 (en) 1992-06-03
DK113083D0 (da) 1983-03-08

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