EP0594749A1 - Modified pf4 compositions and methods of use - Google Patents
Modified pf4 compositions and methods of useInfo
- Publication number
- EP0594749A1 EP0594749A1 EP92915801A EP92915801A EP0594749A1 EP 0594749 A1 EP0594749 A1 EP 0594749A1 EP 92915801 A EP92915801 A EP 92915801A EP 92915801 A EP92915801 A EP 92915801A EP 0594749 A1 EP0594749 A1 EP 0594749A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- entity
- glu
- polypeptide conjugate
- leu
- angiostatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
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- Engineering & Computer Science (AREA)
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- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Utilisation de facteur plaquettaire 4 (PF4) et de PF4 recombinant (rPF4) ainsi que d'analogues modifiés (mutants) de PF4 et de fragments peptidiques de PF4 en vue d'inhiber l'angiogenèse. On montre que le PF4 modifié, des analogues et certains fragments ont une utilité pour traiter les maladies angiogéniques et pour inhiber la prolifération des cellules endothéliales. La présente invention concerne également des modifications de PF4 qui prolongent la demi-vie et facilitent le ciblage de l'activité biologique du PF4 sur des sites spécifiques.Use of platelet factor 4 (PF4) and recombinant PF4 (rPF4) as well as modified analogs (mutants) of PF4 and peptide fragments of PF4 to inhibit angiogenesis. Modified PF4, analogs and certain fragments have been shown to be useful for treating angiogenic diseases and for inhibiting proliferation of endothelial cells. The present invention also relates to modifications of PF4 which prolong the half-life and facilitate targeting of the biological activity of PF4 at specific sites.
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73122291A | 1991-07-15 | 1991-07-15 | |
US731222 | 1991-07-15 | ||
PCT/US1992/005903 WO1993002192A1 (en) | 1991-07-15 | 1992-07-15 | Modified pf4 compositions and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0594749A1 true EP0594749A1 (en) | 1994-05-04 |
Family
ID=24938612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP92915801A Ceased EP0594749A1 (en) | 1991-07-15 | 1992-07-15 | Modified pf4 compositions and methods of use |
Country Status (4)
Country | Link |
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EP (1) | EP0594749A1 (en) |
JP (1) | JPH06509116A (en) |
CA (1) | CA2113206A1 (en) |
WO (1) | WO1993002192A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5800820A (en) * | 1989-01-10 | 1998-09-01 | Repligen Corporation | Methods and compositions for treatment of angiogenic diseases |
AU3592593A (en) * | 1992-01-16 | 1993-08-03 | Repligen Corporation | Novel methods and compositions for treatment of angiogenic diseases |
AU1171795A (en) * | 1993-11-05 | 1995-05-23 | Repligen Corporation | Novel modified pf4 compositions and methods of use |
US5789539A (en) * | 1994-10-26 | 1998-08-04 | Repligen Corporation | Chemokine-like proteins and methods of use |
DE19505960A1 (en) | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Conjugate for the individual dosage of drugs |
US5798356A (en) * | 1995-08-07 | 1998-08-25 | Alcon Laboratories, Inc. | Angiostatic compounds |
US5719167A (en) * | 1995-08-07 | 1998-02-17 | Alcon Laboratories, Inc. | Angiostatic compounds |
IL126953A0 (en) | 1998-11-08 | 1999-09-22 | Yeda Res & Dev | Pharmaceutical compositions comprising porphyrins and some novel porphyrin derivatives |
NO20034351D0 (en) * | 2003-09-29 | 2003-09-29 | Amersham Health As | Optical imaging of endometriosis |
EP3296320A1 (en) | 2012-03-08 | 2018-03-21 | Halozyme, Inc. | Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof |
MX2016003256A (en) | 2013-09-12 | 2016-06-07 | Halozyme Inc | Modified anti-epidermal growth factor receptor antibodies and methods of use thereof. |
WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
EP3724225A1 (en) | 2017-12-15 | 2020-10-21 | Juno Therapeutics, Inc. | Anti-cct5 binding molecules and methods of use thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1203164A (en) * | 1982-03-09 | 1986-04-15 | Thomas J. Mckearn | Antibody conjugates |
AU623589B2 (en) * | 1987-03-02 | 1992-05-21 | Bristol-Myers Squibb Company | Platelet related growth regulator |
US5086164A (en) * | 1989-01-10 | 1992-02-04 | Repligen Corporation | Novel methods and compositions for treatment of angiogenic diseases |
US5112946A (en) * | 1989-07-06 | 1992-05-12 | Repligen Corporation | Modified pf4 compositions and methods of use |
-
1992
- 1992-07-15 JP JP5502920A patent/JPH06509116A/en active Pending
- 1992-07-15 EP EP92915801A patent/EP0594749A1/en not_active Ceased
- 1992-07-15 WO PCT/US1992/005903 patent/WO1993002192A1/en not_active Application Discontinuation
- 1992-07-15 CA CA002113206A patent/CA2113206A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
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See references of WO9302192A1 * |
Also Published As
Publication number | Publication date |
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CA2113206A1 (en) | 1993-02-04 |
JPH06509116A (en) | 1994-10-13 |
WO1993002192A1 (en) | 1993-02-04 |
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