DK1121109T3 - Two-phase composition with tramadol - Google Patents

Two-phase composition with tramadol

Info

Publication number
DK1121109T3
DK1121109T3 DK99953856T DK99953856T DK1121109T3 DK 1121109 T3 DK1121109 T3 DK 1121109T3 DK 99953856 T DK99953856 T DK 99953856T DK 99953856 T DK99953856 T DK 99953856T DK 1121109 T3 DK1121109 T3 DK 1121109T3
Authority
DK
Denmark
Prior art keywords
active substance
weight
tramadol
phase composition
release rate
Prior art date
Application number
DK99953856T
Other languages
Danish (da)
Inventor
Udo Hahn
Walter Wimmer
Bianca Broegmann
Christof Spitzley
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of DK1121109T3 publication Critical patent/DK1121109T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention relates to a pharmaceutical preparation, especially for oral administration, having at least one active substance and formulation components influencing the release of the active substance. Said preparation comprises at least one opioid analgesic as active substance, which is formulated proportionally for rapid and retarded release in such a way that the in vitro release rate from the preparation according to the Ph. Eur. Paddle Method showed a mean value of more than 40 % by weight after one hour, wherein the average value of the in vitro release rate after four hours was still less than 80 % by weight of the active substance.
DK99953856T 1998-10-15 1999-10-15 Two-phase composition with tramadol DK1121109T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE29818454U DE29818454U1 (en) 1998-10-15 1998-10-15 Opioid analgesic

Publications (1)

Publication Number Publication Date
DK1121109T3 true DK1121109T3 (en) 2006-10-02

Family

ID=8063985

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99953856T DK1121109T3 (en) 1998-10-15 1999-10-15 Two-phase composition with tramadol

Country Status (10)

Country Link
EP (1) EP1121109B8 (en)
JP (1) JP5414956B2 (en)
AT (1) ATE327742T1 (en)
AU (1) AU1039400A (en)
CY (1) CY1105168T1 (en)
DE (2) DE29818454U1 (en)
DK (1) DK1121109T3 (en)
ES (1) ES2267301T3 (en)
PT (1) PT1121109E (en)
WO (1) WO2000021520A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030048026A (en) * 2001-07-06 2003-06-18 펜웨스트 파머슈티칼즈 컴파니 Sustained release formulations of oxymorphone
US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
WO2003004031A1 (en) 2001-07-06 2003-01-16 Endo Pharmaceuticals, Inc. Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic
EP2425823A1 (en) 2002-04-05 2012-03-07 Euro-Celtique S.A. Pharmaceutical preparation containing oxycodone and naloxone
JP2006328053A (en) * 2005-04-26 2006-12-07 Takeda Chem Ind Ltd Morphine-containing medicine
US8367107B2 (en) 2006-03-30 2013-02-05 Nippon Zoki Pharmaceutical Co., Ltd. Solid pharmaceutical preparation
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
WO2011124953A2 (en) * 2010-04-07 2011-10-13 Lupin Limited Controlled release pharmaceutical compositions of tapentadol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ260408A (en) * 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
IL110014A (en) * 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
DE4329794C2 (en) * 1993-09-03 1997-09-18 Gruenenthal Gmbh Tramadol salt-containing drugs with delayed release
US5395626A (en) * 1994-03-23 1995-03-07 Ortho Pharmaceutical Corporation Multilayered controlled release pharmaceutical dosage form
US5645858A (en) * 1994-10-06 1997-07-08 Ortho Pharmaceutical Corporation Multilayered controlled release pharmaceutical dosage form
WO1997032573A1 (en) * 1996-03-08 1997-09-12 Nycomed Danmark A/S Modified release multiple-units dosage composition
DE19710008A1 (en) * 1997-03-12 1998-09-17 Basf Ag Solid, at least two-phase formulations of a sustained-release opioid analgesic

Also Published As

Publication number Publication date
ES2267301T3 (en) 2007-03-01
JP2002527384A (en) 2002-08-27
DE29818454U1 (en) 1999-01-14
WO2000021520A3 (en) 2000-08-03
CY1105168T1 (en) 2010-03-03
EP1121109B1 (en) 2006-05-31
PT1121109E (en) 2006-09-29
EP1121109A2 (en) 2001-08-08
JP5414956B2 (en) 2014-02-12
AU1039400A (en) 2000-05-01
WO2000021520A2 (en) 2000-04-20
EP1121109B8 (en) 2006-07-19
DE59913493D1 (en) 2006-07-06
ATE327742T1 (en) 2006-06-15

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