DK1117437T3 - Anvendelse af forbindelser, der reducerer alfa2-antiplasmin in vivo, til fremstilling af en sammensætning til behandling af iskæmiske slagtilfælde - Google Patents
Anvendelse af forbindelser, der reducerer alfa2-antiplasmin in vivo, til fremstilling af en sammensætning til behandling af iskæmiske slagtilfældeInfo
- Publication number
- DK1117437T3 DK1117437T3 DK99948942T DK99948942T DK1117437T3 DK 1117437 T3 DK1117437 T3 DK 1117437T3 DK 99948942 T DK99948942 T DK 99948942T DK 99948942 T DK99948942 T DK 99948942T DK 1117437 T3 DK1117437 T3 DK 1117437T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- antiplasmin
- ischemic stroke
- vivo
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/484—Plasmin (3.4.21.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98203280 | 1998-09-29 | ||
EP99202004A EP1062953A1 (en) | 1999-06-22 | 1999-06-22 | Use of compounds that reduce alpha2-antiplasmin in vivo for the preparation of a composition for the treatment of ischemic stroke |
PCT/EP1999/007405 WO2000018436A1 (en) | 1998-09-29 | 1999-09-24 | Use of compounds that reduce alpha2-antiplasmin in vivo for the preparation of a composition for the treatment of ischemic stroke |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1117437T3 true DK1117437T3 (da) | 2007-04-10 |
Family
ID=26150731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99948942T DK1117437T3 (da) | 1998-09-29 | 1999-09-24 | Anvendelse af forbindelser, der reducerer alfa2-antiplasmin in vivo, til fremstilling af en sammensætning til behandling af iskæmiske slagtilfælde |
Country Status (12)
Country | Link |
---|---|
US (1) | US6946438B1 (ja) |
EP (1) | EP1117437B1 (ja) |
JP (1) | JP4577992B2 (ja) |
CN (1) | CN1191856C (ja) |
AT (1) | ATE349226T1 (ja) |
AU (1) | AU6200599A (ja) |
CA (1) | CA2344317C (ja) |
DE (1) | DE69934595T2 (ja) |
DK (1) | DK1117437T3 (ja) |
ES (1) | ES2276536T3 (ja) |
HK (1) | HK1041449B (ja) |
WO (1) | WO2000018436A1 (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60131450T2 (de) * | 2000-12-21 | 2008-10-16 | Thrombogenics N.V. | Hefeexpressionsvektor und verfahren zur herstellung eines rekombinanten proteins durch expression in einer hefezelle |
CN1684706A (zh) * | 2002-07-23 | 2005-10-19 | 路德维格癌症研究所 | 活化或抑制vegf-d和vegf-c的方法和组合物 |
EP2246417B1 (en) * | 2004-04-22 | 2015-01-21 | Grifols Therapeutics Inc. | Recombinantly modified plasmin |
AU2008331545B2 (en) * | 2007-11-29 | 2014-01-16 | Grifols Therapeutics Inc. | Recombinantly modified plasmin |
EP2297317A4 (en) * | 2008-06-04 | 2011-12-07 | Talecris Biotherapeutics Inc | COMPOSITION, METHOD AND NECESSARY FOR THE PREPARATION OF PLASMINE |
HUE025670T2 (en) | 2009-03-03 | 2016-04-28 | Grifols Therapeutics Inc | A method for producing plasminogen |
KR20120050442A (ko) | 2009-07-10 | 2012-05-18 | 쓰롬보제닉스 엔.브이. | 플라스미노겐 및 플라스민의 변이체 |
ES2534911T3 (es) | 2009-08-28 | 2015-04-30 | Thrombogenics N.V. | Uso de plasmina para el tratamiento de fallo de filtración después de trabeculectomía |
CA2823491A1 (en) | 2011-01-05 | 2012-07-12 | Thrombogenics Nv | Plasminogen and plasmin variants |
US9644196B2 (en) | 2011-08-12 | 2017-05-09 | Thrombogenics Nv | Plasminogen and plasmin variants |
CA2846667A1 (en) * | 2011-09-06 | 2013-03-14 | Guy L. Reed | Serpinf2-binding molecules and methods of use |
EP3395355A4 (en) | 2015-12-18 | 2019-06-12 | Talengen International Limited | METHOD FOR PREVENTING AND TREATING CERVICAL EROSION |
CN106890325A (zh) * | 2015-12-18 | 2017-06-27 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗糖尿病性神经损伤及其相关病症的方法 |
WO2017101873A1 (zh) * | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗放射性和化学性损伤的方法 |
DK3391902T3 (da) | 2015-12-18 | 2023-11-20 | Talengen Int Ltd | Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati |
US11400142B2 (en) | 2015-12-18 | 2022-08-02 | Talengen International Limited | Treatment of diabetic nerve injury comprising administering plasminogen |
EP3395354B1 (en) | 2015-12-18 | 2024-05-22 | Talengen International Limited | Plasminogen for use in treating diabetic nephropathy |
CN108463240A (zh) | 2015-12-18 | 2018-08-28 | 泰伦基国际有限公司 | 一种预防或治疗糖尿病性视网膜病变的方法 |
EP3556384B1 (en) | 2016-12-15 | 2024-04-10 | Talengen International Limited | Plasminogen for use in treating diabetes |
US20230134886A1 (en) * | 2019-10-10 | 2023-05-04 | University Of Kentucky Research Foundation | A machine learning algorithm for predicting clinical outcomes and identifying drug targets in ischemic stroke |
WO2023004626A1 (zh) * | 2021-07-28 | 2023-02-02 | 北京沙东生物技术有限公司 | 一种骨髓瘤生物标志物serpinf2及其应用 |
CN114736948B (zh) * | 2022-06-10 | 2022-11-08 | 深圳市帝迈生物技术有限公司 | 一种α2-抗纤溶酶活性测定试剂盒 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5520912A (en) * | 1993-07-02 | 1996-05-28 | Immuno Aktiengesellschaft | Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen |
WO1998012329A2 (en) * | 1996-09-20 | 1998-03-26 | The General Hospital Corporation | Composition and method for enhancing fibrinolysis using antibodies to alpha-2-antiplasmin |
-
1999
- 1999-09-24 EP EP99948942A patent/EP1117437B1/en not_active Expired - Lifetime
- 1999-09-24 CN CNB998115207A patent/CN1191856C/zh not_active Expired - Fee Related
- 1999-09-24 AU AU62005/99A patent/AU6200599A/en not_active Abandoned
- 1999-09-24 AT AT99948942T patent/ATE349226T1/de not_active IP Right Cessation
- 1999-09-24 DE DE69934595T patent/DE69934595T2/de not_active Expired - Lifetime
- 1999-09-24 DK DK99948942T patent/DK1117437T3/da active
- 1999-09-24 JP JP2000571953A patent/JP4577992B2/ja not_active Expired - Fee Related
- 1999-09-24 WO PCT/EP1999/007405 patent/WO2000018436A1/en active IP Right Grant
- 1999-09-24 ES ES99948942T patent/ES2276536T3/es not_active Expired - Lifetime
- 1999-09-24 US US09/806,178 patent/US6946438B1/en not_active Expired - Lifetime
- 1999-09-24 CA CA2344317A patent/CA2344317C/en not_active Expired - Fee Related
-
2002
- 2002-04-29 HK HK02103164.2A patent/HK1041449B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE349226T1 (de) | 2007-01-15 |
HK1041449B (zh) | 2005-08-19 |
ES2276536T3 (es) | 2007-06-16 |
CA2344317A1 (en) | 2000-04-06 |
HK1041449A1 (en) | 2002-07-12 |
WO2000018436A1 (en) | 2000-04-06 |
EP1117437B1 (en) | 2006-12-27 |
DE69934595D1 (de) | 2007-02-08 |
US6946438B1 (en) | 2005-09-20 |
CN1191856C (zh) | 2005-03-09 |
JP2002525340A (ja) | 2002-08-13 |
CA2344317C (en) | 2012-01-24 |
AU6200599A (en) | 2000-04-17 |
JP4577992B2 (ja) | 2010-11-10 |
EP1117437A1 (en) | 2001-07-25 |
DE69934595T2 (de) | 2007-10-04 |
CN1320045A (zh) | 2001-10-31 |
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