DK1071433T3 - 2',2'-difluornucleosider til immunosuppressiv behandling og kombinationspræparater - Google Patents
2',2'-difluornucleosider til immunosuppressiv behandling og kombinationspræparaterInfo
- Publication number
- DK1071433T3 DK1071433T3 DK99912962T DK99912962T DK1071433T3 DK 1071433 T3 DK1071433 T3 DK 1071433T3 DK 99912962 T DK99912962 T DK 99912962T DK 99912962 T DK99912962 T DK 99912962T DK 1071433 T3 DK1071433 T3 DK 1071433T3
- Authority
- DK
- Denmark
- Prior art keywords
- difluoronucleosides
- immunosuppressive treatment
- combination preparations
- preparations
- immunosuppressive
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT63698 | 1998-04-14 | ||
PCT/AT1999/000093 WO1999052514A2 (de) | 1998-04-14 | 1999-04-14 | Pharmazeutische zusammensetzung und kombinationspräparate zur immunosuppressiven therapie |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1071433T3 true DK1071433T3 (da) | 2003-04-07 |
Family
ID=3495843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99912962T DK1071433T3 (da) | 1998-04-14 | 1999-04-14 | 2',2'-difluornucleosider til immunosuppressiv behandling og kombinationspræparater |
Country Status (27)
Country | Link |
---|---|
US (1) | US6555518B1 (da) |
EP (1) | EP1071433B1 (da) |
JP (1) | JP2002511405A (da) |
KR (1) | KR100450248B1 (da) |
CN (1) | CN1312719A (da) |
AR (1) | AR019053A1 (da) |
AT (1) | ATE229338T1 (da) |
AU (1) | AU3126799A (da) |
BR (1) | BR9909617A (da) |
CA (1) | CA2327431A1 (da) |
CO (1) | CO5011041A1 (da) |
DE (1) | DE59903751D1 (da) |
DK (1) | DK1071433T3 (da) |
EA (1) | EA200001061A1 (da) |
ES (1) | ES2190647T3 (da) |
HU (1) | HUP0102671A3 (da) |
ID (1) | ID27201A (da) |
IL (2) | IL138888A0 (da) |
NO (1) | NO20005179D0 (da) |
PE (1) | PE20000424A1 (da) |
PL (1) | PL343769A1 (da) |
PT (1) | PT1071433E (da) |
SV (1) | SV1999000039A (da) |
TR (2) | TR200002969T2 (da) |
TW (1) | TW466112B (da) |
WO (1) | WO1999052514A2 (da) |
ZA (1) | ZA200005510B (da) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATA173599A (de) * | 1999-10-14 | 2001-04-15 | Lilly Co Eli | Pharmazeutisches produkt |
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
EP1736478B1 (en) | 2000-05-26 | 2015-07-22 | IDENIX Pharmaceuticals, Inc. | Methods and compositions for treating flaviviruses and pestiviruses |
TWI296196B (en) * | 2001-04-06 | 2008-05-01 | Wyeth Corp | Antineoplastic combinations |
TWI233359B (en) * | 2001-04-06 | 2005-06-01 | Wyeth Corp | Pharmaceutical composition for treating neoplasm |
EP1385551B1 (en) * | 2001-04-06 | 2008-09-03 | Wyeth | Antineoplastic combinations comprising cci-779 (rapamycin derivative) together with gemcitabine or fluorouracil |
ZA200603888B (en) * | 2001-06-01 | 2007-05-30 | Wyeth Corp | Antineoplastic combinations |
BR0307712A (pt) * | 2002-02-14 | 2005-05-24 | Pharmasset Ltd | Composto, composição e uso dos mesmos no tratamento de infecções por flaviviridae e proliferação celular anormal |
RU2005118421A (ru) | 2002-11-15 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | 2'-разветвленные нуклеозиды и мутация flaviviridae |
DE10323279A1 (de) * | 2003-05-21 | 2004-12-16 | Stada Arzneimittel Ag | Gebrauchsfertige Gemcitabin-Lösungen |
DE10323278A1 (de) * | 2003-05-21 | 2004-12-16 | Stada Arzneimittel Ag | Gebrauchsfertige Gemcitabin-Lösungskonzentrate |
ATE442854T1 (de) * | 2005-03-17 | 2009-10-15 | Proyecto Biomedicina Cima Sl | Verwendung von 5'-methylthioadenosin zur prävention und/oder behandlung von autoimmunkrankheiten und/oder transplantatabstossung |
ES2259552B1 (es) * | 2005-03-17 | 2007-06-16 | Proyecto De Biomedicina Cima, S.L. | Empleo de 5'-metiltioadenosina (mta) en la prevencion y/o tratamiento de enfermedades autoinmunes y/o rechazo de transplantes. |
AT502221A1 (de) * | 2005-07-20 | 2007-02-15 | Pharmacon Forschung & Beratung Gmbh | Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung |
AR076262A1 (es) | 2009-04-06 | 2011-06-01 | Eisai Inc | Derivados heterociclicos de diazepin-2-ona, composiciones farmaceuticas y sus usos en el tratamiento del cancer |
SI2833905T1 (en) | 2012-04-04 | 2018-08-31 | Halozyme, Inc. | Combination therapy with hyaluronidase and tumane-directed taxane |
CN107184592A (zh) * | 2017-05-17 | 2017-09-22 | 广东艾时代生物科技有限责任公司 | 吉西他滨在制备治疗类风湿性关节炎药物中的应用 |
US20190351031A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
WO2020001475A1 (en) | 2018-06-29 | 2020-01-02 | Shanghai Changchengyiyaokeji Company Limited | Phosphorus-containing prodrugs of gemcitabine |
RU2764742C1 (ru) * | 2021-04-09 | 2022-01-20 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. академика В.И. Шумакова" Минздрава России) | Способ подбора режима иммуносупрессии детям раннего возраста в отдаленном периоде после трансплантации печени |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
CA1264738A (en) * | 1984-12-04 | 1990-01-23 | Eli Lilly And Company | Treatment of tumors in mammals |
US4914028A (en) * | 1988-02-10 | 1990-04-03 | Eli Lilly And Company | Method of preparing beta-2',2'-difluoronucleosides |
JPH0232093A (ja) * | 1988-06-08 | 1990-02-01 | Merrell Dow Pharmaceut Inc | 抗レトロウィルスジフルオロ化ヌクレオシド類 |
AU4134793A (en) * | 1992-06-22 | 1993-12-23 | Eli Lilly And Company | 2'-deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates |
US6291504B1 (en) * | 1999-10-20 | 2001-09-18 | Dupont Pharmaceuticals Company | Acylsemicarbazides and their uses |
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1999
- 1999-04-09 TW TW088105804A patent/TW466112B/zh active
- 1999-04-12 PE PE1999000297A patent/PE20000424A1/es not_active Application Discontinuation
- 1999-04-13 SV SV1999000039A patent/SV1999000039A/es unknown
- 1999-04-13 CO CO99021850A patent/CO5011041A1/es unknown
- 1999-04-13 AR ARP990101686A patent/AR019053A1/es unknown
- 1999-04-14 CA CA002327431A patent/CA2327431A1/en not_active Abandoned
- 1999-04-14 JP JP2000543124A patent/JP2002511405A/ja active Pending
- 1999-04-14 ES ES99912962T patent/ES2190647T3/es not_active Expired - Lifetime
- 1999-04-14 IL IL13888899A patent/IL138888A0/xx unknown
- 1999-04-14 DE DE59903751T patent/DE59903751D1/de not_active Expired - Fee Related
- 1999-04-14 AT AT99912962T patent/ATE229338T1/de not_active IP Right Cessation
- 1999-04-14 WO PCT/AT1999/000093 patent/WO1999052514A2/de active IP Right Grant
- 1999-04-14 TR TR2000/02969T patent/TR200002969T2/xx unknown
- 1999-04-14 EA EA200001061A patent/EA200001061A1/ru unknown
- 1999-04-14 AU AU31267/99A patent/AU3126799A/en not_active Abandoned
- 1999-04-14 DK DK99912962T patent/DK1071433T3/da active
- 1999-04-14 HU HU0102671A patent/HUP0102671A3/hu unknown
- 1999-04-14 BR BR9909617-0A patent/BR9909617A/pt not_active Application Discontinuation
- 1999-04-14 PT PT99912962T patent/PT1071433E/pt unknown
- 1999-04-14 TR TR2001/01633T patent/TR200101633T2/xx unknown
- 1999-04-14 KR KR10-2000-7011402A patent/KR100450248B1/ko not_active IP Right Cessation
- 1999-04-14 EP EP99912962A patent/EP1071433B1/de not_active Expired - Lifetime
- 1999-04-14 CN CN99807371A patent/CN1312719A/zh active Pending
- 1999-04-14 ID IDW20002331A patent/ID27201A/id unknown
- 1999-04-14 PL PL99343769A patent/PL343769A1/xx unknown
-
2000
- 2000-10-05 IL IL138888A patent/IL138888A/en not_active IP Right Cessation
- 2000-10-09 ZA ZA200005510A patent/ZA200005510B/xx unknown
- 2000-10-13 NO NO20005179A patent/NO20005179D0/no not_active Application Discontinuation
- 2000-10-13 US US09/687,565 patent/US6555518B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AR019053A1 (es) | 2001-12-26 |
JP2002511405A (ja) | 2002-04-16 |
SV1999000039A (es) | 1999-11-25 |
TR200101633T2 (tr) | 2002-06-21 |
WO1999052514A3 (de) | 2000-07-06 |
DE59903751D1 (de) | 2003-01-23 |
CA2327431A1 (en) | 1999-10-21 |
AU3126799A (en) | 1999-11-01 |
ES2190647T3 (es) | 2003-08-01 |
CO5011041A1 (es) | 2001-02-28 |
HUP0102671A3 (en) | 2002-04-29 |
TW466112B (en) | 2001-12-01 |
ATE229338T1 (de) | 2002-12-15 |
NO20005179L (no) | 2000-10-13 |
US6555518B1 (en) | 2003-04-29 |
ID27201A (id) | 2001-03-08 |
WO1999052514A2 (de) | 1999-10-21 |
NO20005179D0 (no) | 2000-10-13 |
IL138888A0 (en) | 2001-11-25 |
IL138888A (en) | 2009-05-04 |
ZA200005510B (en) | 2001-05-08 |
KR20010034779A (ko) | 2001-04-25 |
PT1071433E (pt) | 2003-04-30 |
HUP0102671A2 (hu) | 2001-12-28 |
EA200001061A1 (ru) | 2001-04-23 |
PE20000424A1 (es) | 2000-05-19 |
EP1071433B1 (de) | 2002-12-11 |
EP1071433A2 (de) | 2001-01-31 |
TR200002969T2 (tr) | 2001-01-22 |
CN1312719A (zh) | 2001-09-12 |
PL343769A1 (en) | 2001-09-10 |
KR100450248B1 (ko) | 2004-09-24 |
BR9909617A (pt) | 2000-12-12 |
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