DK1054887T3 - Bicyclic pyridine and pyrimidine derivatives as neuropeptide Y receptor antagonists - Google Patents

Bicyclic pyridine and pyrimidine derivatives as neuropeptide Y receptor antagonists

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Publication number
DK1054887T3
DK1054887T3 DK99906756T DK99906756T DK1054887T3 DK 1054887 T3 DK1054887 T3 DK 1054887T3 DK 99906756 T DK99906756 T DK 99906756T DK 99906756 T DK99906756 T DK 99906756T DK 1054887 T3 DK1054887 T3 DK 1054887T3
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DK
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Prior art keywords
neuropeptide
receptor antagonists
pyrimidine derivatives
bicyclic pyridine
bicyclic
Prior art date
Application number
DK99906756T
Other languages
Danish (da)
Inventor
Mark H Norman
Nianhe Han
Christopher H Fotsch
Ning Chen
Longbin Liu
Clarence R Hurt
Tracy J Jenkins
Ofir A Moreno
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of DK1054887T3 publication Critical patent/DK1054887T3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Diabetes (AREA)
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  • Virology (AREA)
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Abstract

There are provided compounds, compositions and methods of use thereof in the modulation of feeding behavior, obesity, diabetes, cancer (tumor), inflammatory disorders, depression, stress related disorders, Alzheimer's disease and other disease conditions.
DK99906756T 1998-02-06 1999-02-05 Bicyclic pyridine and pyrimidine derivatives as neuropeptide Y receptor antagonists DK1054887T3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7398198P 1998-02-06 1998-02-06
US7392798P 1998-02-06 1998-02-06
US9348298P 1998-07-20 1998-07-20
US9357798P 1998-07-20 1998-07-20
US09/246,775 US6187777B1 (en) 1998-02-06 1999-02-04 Compounds and methods which modulate feeding behavior and related diseases

Publications (1)

Publication Number Publication Date
DK1054887T3 true DK1054887T3 (en) 2006-05-08

Family

ID=27535987

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99906756T DK1054887T3 (en) 1998-02-06 1999-02-05 Bicyclic pyridine and pyrimidine derivatives as neuropeptide Y receptor antagonists

Country Status (13)

Country Link
US (2) US6187777B1 (en)
EP (1) EP1054887B1 (en)
JP (1) JP2003502272A (en)
AT (1) ATE323088T1 (en)
AU (1) AU747920B2 (en)
CA (1) CA2319275C (en)
CY (1) CY1105476T1 (en)
DE (1) DE69930835T2 (en)
DK (1) DK1054887T3 (en)
ES (1) ES2257851T3 (en)
PT (1) PT1054887E (en)
SI (1) SI1054887T1 (en)
WO (1) WO1999040091A1 (en)

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