DK105334C - Fremgangsmåde til fremstilling af 16β-alkylderivater af cortison, hydrocortison, prednison eller prednisolon eller 21-estrene af disse forbindelser. - Google Patents
Fremgangsmåde til fremstilling af 16β-alkylderivater af cortison, hydrocortison, prednison eller prednisolon eller 21-estrene af disse forbindelser.Info
- Publication number
- DK105334C DK105334C DK267258AA DK267258A DK105334C DK 105334 C DK105334 C DK 105334C DK 267258A A DK267258A A DK 267258AA DK 267258 A DK267258 A DK 267258A DK 105334 C DK105334 C DK 105334C
- Authority
- DK
- Denmark
- Prior art keywords
- cortisone
- prednisolone
- hydrocortisone
- prednisone
- esters
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C07J71/0052—Nitrogen only at position 16(17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67314157A | 1957-07-22 | 1957-07-22 | |
| US733843A US3164618A (en) | 1957-07-22 | 1958-05-08 | Alkylated steroids |
| US5031460A | 1960-08-18 | 1960-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK105334C true DK105334C (da) | 1966-09-19 |
Family
ID=27367724
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK385560AA DK109512C (da) | 1957-07-22 | 1958-07-21 | Fremgangsmåde til fremstilling af 16(αellerβ)-alkyderivater af cortison, hydrocortison, prednison eller prednisolon eller 21-estrene af disse forbindelser. |
| DK550163AA DK108789C (da) | 1957-07-22 | 1958-07-21 | Fremgangsmåde til fremstilling af 9α-chlor- eller 9α-fluor-16(α eller β)-alkylderivater af prednison og prednisolon. |
| DK267258AA DK105334C (da) | 1957-07-22 | 1958-07-21 | Fremgangsmåde til fremstilling af 16β-alkylderivater af cortison, hydrocortison, prednison eller prednisolon eller 21-estrene af disse forbindelser. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK385560AA DK109512C (da) | 1957-07-22 | 1958-07-21 | Fremgangsmåde til fremstilling af 16(αellerβ)-alkyderivater af cortison, hydrocortison, prednison eller prednisolon eller 21-estrene af disse forbindelser. |
| DK550163AA DK108789C (da) | 1957-07-22 | 1958-07-21 | Fremgangsmåde til fremstilling af 9α-chlor- eller 9α-fluor-16(α eller β)-alkylderivater af prednison og prednisolon. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US3164618A (da) |
| CY (1) | CY576A (da) |
| DE (2) | DE1286034B (da) |
| DK (3) | DK109512C (da) |
| FR (1) | FR1326306A (da) |
| GB (2) | GB901092A (da) |
| MY (1) | MY7100134A (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3947409A (en) * | 1958-06-19 | 1976-03-30 | Merck & Co., Inc. | 16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof |
| KR101591482B1 (ko) | 2008-05-28 | 2016-02-03 | 레베라겐 바이오파마 인코포레이티드 | 질환의 치료를 위한 ＮＦ-κＢ 의 비호르몬성 스테로이드 조절제 |
| CN101417912B (zh) * | 2008-11-10 | 2012-11-14 | 湖南玉新药业有限公司 | 制备倍他米松醋酸酯的方法 |
| EP2556083A4 (en) | 2010-04-05 | 2013-12-04 | Validus Biopharma Inc | NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT |
| US10799514B2 (en) | 2015-06-29 | 2020-10-13 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-kappa beta for treatment of disease |
| CN105017377B (zh) * | 2015-07-06 | 2018-02-16 | 湖南新合新生物医药有限公司 | 肾上腺皮质激素药物中间体的制备方法 |
| US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
| WO2020191087A1 (en) | 2019-03-18 | 2020-09-24 | Ptc Therapeutics, Inc. | Therapeutic combinations for use in treating a muscular dystrophy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB741732A (en) * | 1951-12-08 | 1955-12-14 | Upjohn Co | Steroid compounds |
| GB736182A (en) * | 1952-07-16 | 1955-09-07 | Upjohn Co | Halogenation of steroid compounds |
| US2790799A (en) * | 1952-11-27 | 1957-04-30 | Syntex Sa | Cyclopentanophenanthrene derivatives and process for the production thereof |
| GB748914A (en) * | 1953-05-13 | 1956-05-16 | Glidden Co | Improvements in or relating to preparation of 21-halo steroids |
| US2932656A (en) * | 1957-06-19 | 1960-04-12 | Merck & Co Inc | Production of delta1, 4-3, 20-diketopregnadienes from the corresponding semicarbazones |
-
1958
- 1958-05-08 US US733843A patent/US3164618A/en not_active Expired - Lifetime
- 1958-07-21 DK DK385560AA patent/DK109512C/da active
- 1958-07-21 DK DK550163AA patent/DK108789C/da active
- 1958-07-21 DK DK267258AA patent/DK105334C/da active
- 1958-07-21 DE DE1958SC028165 patent/DE1286034B/de active Pending
- 1958-07-22 GB GB23522/58A patent/GB901092A/en not_active Expired
- 1958-07-22 FR FR770832A patent/FR1326306A/fr not_active Expired
- 1958-07-22 GB GB7840/62A patent/GB901093A/en not_active Expired
- 1958-11-21 DE DESCH24430A patent/DE1181705B/de active Pending
-
1960
- 1960-08-18 US US50314A patent/US3461117A/en not_active Expired - Lifetime
-
1971
- 1971-02-15 CY CY57671A patent/CY576A/xx unknown
- 1971-12-31 MY MY1971134A patent/MY7100134A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB901092A (en) | 1962-07-11 |
| DK109512C (da) | 1968-05-06 |
| MY7100134A (en) | 1971-12-31 |
| US3164618A (en) | 1965-01-05 |
| DE1286034B (de) | 1969-01-02 |
| FR1326306A (fr) | 1963-05-10 |
| CY576A (en) | 1971-02-15 |
| US3461117A (en) | 1969-08-12 |
| GB901093A (en) | 1962-07-11 |
| DK108789C (da) | 1968-02-12 |
| DE1181705B (de) | 1964-11-19 |
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