DK1015494T3 - Fremgangsmåde til fremstilling af katalytiske antistoffer - Google Patents

Fremgangsmåde til fremstilling af katalytiske antistoffer

Info

Publication number
DK1015494T3
DK1015494T3 DK98943578T DK98943578T DK1015494T3 DK 1015494 T3 DK1015494 T3 DK 1015494T3 DK 98943578 T DK98943578 T DK 98943578T DK 98943578 T DK98943578 T DK 98943578T DK 1015494 T3 DK1015494 T3 DK 1015494T3
Authority
DK
Denmark
Prior art keywords
growth factor
present
factor precursor
catalytic antibodies
nucleic acid
Prior art date
Application number
DK98943578T
Other languages
Danish (da)
English (en)
Inventor
Herbert Rudolf Treutlein
Gabriele Maria Suess
David Mathew Tarlinton
Frank Koentgen
Original Assignee
Frank Koentgen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frank Koentgen filed Critical Frank Koentgen
Application granted granted Critical
Publication of DK1015494T3 publication Critical patent/DK1015494T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK98943578T 1997-09-19 1998-09-18 Fremgangsmåde til fremstilling af katalytiske antistoffer DK1015494T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPO9306A AUPO930697A0 (en) 1997-09-19 1997-09-19 Catalytic antibodies and a method of producing same

Publications (1)

Publication Number Publication Date
DK1015494T3 true DK1015494T3 (da) 2006-05-01

Family

ID=3803589

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98943578T DK1015494T3 (da) 1997-09-19 1998-09-18 Fremgangsmåde til fremstilling af katalytiske antistoffer

Country Status (12)

Country Link
US (3) US6590080B1 (de)
EP (1) EP1015494B1 (de)
AT (1) ATE312845T1 (de)
AU (1) AUPO930697A0 (de)
CA (1) CA2304365A1 (de)
DE (1) DE69832804T2 (de)
DK (1) DK1015494T3 (de)
ES (1) ES2253824T3 (de)
GB (1) GB2345694B (de)
HK (1) HK1029350A1 (de)
NZ (3) NZ524429A (de)
WO (1) WO1999015563A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU731580B2 (en) * 1996-03-26 2001-04-05 Frank Koentgen Precursors of catalytic antibodies
JP2006504694A (ja) * 2002-09-18 2006-02-09 サントル・オスピタリエ・ドゥ・リュニヴェルシテ・ドゥ・モントリオール・（シー・エイチ・ユー・エム） Ｇｈｒｈ類似体
WO2005000898A2 (en) 2003-06-27 2005-01-06 Biogen Idec Ma Inc. Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
CA2545603A1 (en) 2003-11-12 2005-05-26 Biogen Idec Ma Inc. Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto
US20070275873A1 (en) * 2004-04-29 2007-11-29 Heidner Hans W Methods and Compositions Comprising Protein L Immunoglobulin Binding Domains for Cell-Specific Targeting
CN101534848B (zh) 2006-09-19 2013-07-17 亚洲大学校产学协力团 抗动物病毒的抗病毒剂
US10585098B2 (en) 2009-11-23 2020-03-10 The Johns Hopkins University Optimizing diagnostics for galactofuranose containing antigens
US10288611B2 (en) * 2009-11-23 2019-05-14 The Johns Hopkins University Lateral flow device for diagnosing microbial infections
US9738707B2 (en) 2011-07-15 2017-08-22 Biogen Ma Inc. Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto
EP2565667A1 (de) 2011-08-31 2013-03-06 Friedrich-Alexander-Universität Erlangen-Nürnberg Ankunftsrichtungsschätzung mittels mit einem Wasserzeichen versehenen Audiosignalen und Mikrofonanordnungen
CN118146306A (zh) * 2013-09-25 2024-06-07 西托姆克斯治疗公司 基质金属蛋白酶底物和其它可切割部分及其使用方法
WO2015095195A1 (en) 2013-12-16 2015-06-25 The Johns Hopkins University Interferon-gamma release assays for diagnosis of invasive fungal infections
IL302642A (en) 2014-01-31 2023-07-01 Cytomx Therapeutics Inc Polypeptide substrates that activate matriptase and U-plasminogen and other cleavable groups, preparations containing them and their uses
MA41374A (fr) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci
US12049505B2 (en) 2018-12-06 2024-07-30 Cytomx Therapeutics, Inc. Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2540508B2 (ja) * 1983-11-29 1996-10-02 イージエン・インコーポレイテッド 化学反応を触媒する方法
US5126258A (en) * 1984-09-07 1992-06-30 Scripps Clinic And Research Foundation Molecules with antibody combining sites that exhibit catalytic properties
US4900674A (en) * 1987-05-28 1990-02-13 Scripps Clinic And Research Foundation Antibody combining sites that exhibit amide or ester synthase activity
US5190865A (en) * 1988-11-18 1993-03-02 The Regents Of The University Of California Antibody-enhanced stereospecific hydrolyses
US5215889A (en) * 1988-11-18 1993-06-01 The Regents Of The University Of California Catalytic and reactive polypeptides and methods for their preparation and use
US5219732A (en) * 1989-09-05 1993-06-15 The Regents Of The University Of California Antibody-mediated cofactor-driven reactions
US5187086A (en) * 1990-01-26 1993-02-16 Scripps Clinic And Research Foundation Molecules with antibody combining sites that catalyze hydrolysis reactions through use of a charged hapten
SE9002212D0 (sv) * 1990-06-21 1990-06-21 Hightech Receptor Ab Igg binding protein
JPH06510529A (ja) * 1991-08-05 1994-11-24 イゲン，インコーポレーテッド 目標とする触媒性たんぱく質により活性化されるプロドラッグ
IL104829A (en) * 1992-02-24 1999-04-11 Igen Inc Selection is based on a response to the expression and concentration of catalytic units
US5439812A (en) * 1992-04-08 1995-08-08 The Pennsylvania Research Corporation Antibodies catalyzing deamidation of proteins
SE9201331D0 (sv) * 1992-04-28 1992-04-28 Hightech Receptor C O Active Protein l och hybridproteiner daerav
GB9209804D0 (en) * 1992-05-07 1992-06-24 Health Lab Service Board Novel immunoglobulin binding proteins process for their production and recombinant dna molecules coding therefor
EP0935612A4 (de) * 1996-03-26 2001-12-12 Amrad Operations Pty Ltd Vorläufer von katalytischen antikörper
AU731580B2 (en) * 1996-03-26 2001-04-05 Frank Koentgen Precursors of catalytic antibodies
US7253178B2 (en) * 2001-03-28 2007-08-07 Eisai Co., Ltd. Carboxylic acids
TWI311133B (en) * 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
EP1394147A4 (de) * 2001-06-04 2007-10-24 Eisai R&D Man Co Ltd Carbonsäurederivat und eine ein salz oder ein ester davon enthaltende medizin
US7371777B2 (en) * 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist

Also Published As

Publication number Publication date
HK1029350A1 (en) 2001-03-30
US20030148484A1 (en) 2003-08-07
GB2345694B (en) 2002-07-17
AUPO930697A0 (en) 1997-10-09
NZ515603A (en) 2003-04-29
ES2253824T3 (es) 2006-06-01
WO1999015563A9 (en) 1999-06-03
EP1015494A1 (de) 2000-07-05
DE69832804T2 (de) 2006-08-10
US20090269355A1 (en) 2009-10-29
DE69832804D1 (de) 2006-01-19
CA2304365A1 (en) 1999-04-01
US6590080B1 (en) 2003-07-08
GB2345694A (en) 2000-07-19
WO1999015563A1 (en) 1999-04-01
ATE312845T1 (de) 2005-12-15
EP1015494A4 (de) 2001-12-12
EP1015494B1 (de) 2005-12-14
NZ503454A (en) 2004-01-30
NZ524429A (en) 2004-06-25
GB0009758D0 (en) 2000-06-07

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