DK1015494T3 - Fremgangsmåde til fremstilling af katalytiske antistoffer - Google Patents

Fremgangsmåde til fremstilling af katalytiske antistoffer

Info

Publication number
DK1015494T3
DK1015494T3 DK98943578T DK98943578T DK1015494T3 DK 1015494 T3 DK1015494 T3 DK 1015494T3 DK 98943578 T DK98943578 T DK 98943578T DK 98943578 T DK98943578 T DK 98943578T DK 1015494 T3 DK1015494 T3 DK 1015494T3
Authority
DK
Denmark
Prior art keywords
growth factor
present
factor precursor
catalytic antibodies
nucleic acid
Prior art date
Application number
DK98943578T
Other languages
Danish (da)
English (en)
Inventor
Herbert Rudolf Treutlein
Gabriele Maria Suess
David Mathew Tarlinton
Frank Koentgen
Original Assignee
Frank Koentgen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frank Koentgen filed Critical Frank Koentgen
Application granted granted Critical
Publication of DK1015494T3 publication Critical patent/DK1015494T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK98943578T 1997-09-19 1998-09-18 Fremgangsmåde til fremstilling af katalytiske antistoffer DK1015494T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPO9306A AUPO930697A0 (en) 1997-09-19 1997-09-19 Catalytic antibodies and a method of producing same

Publications (1)

Publication Number Publication Date
DK1015494T3 true DK1015494T3 (da) 2006-05-01

Family

ID=3803589

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98943578T DK1015494T3 (da) 1997-09-19 1998-09-18 Fremgangsmåde til fremstilling af katalytiske antistoffer

Country Status (12)

Country Link
US (3) US6590080B1 (de)
EP (1) EP1015494B1 (de)
AT (1) ATE312845T1 (de)
AU (1) AUPO930697A0 (de)
CA (1) CA2304365A1 (de)
DE (1) DE69832804T2 (de)
DK (1) DK1015494T3 (de)
ES (1) ES2253824T3 (de)
GB (1) GB2345694B (de)
HK (1) HK1029350A1 (de)
NZ (3) NZ503454A (de)
WO (1) WO1999015563A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU731580B2 (en) * 1996-03-26 2001-04-05 Frank Koentgen Precursors of catalytic antibodies
US20060128615A1 (en) * 2002-09-18 2006-06-15 Pierrette Gaudreau Ghrh analogues
WO2005000898A2 (en) 2003-06-27 2005-01-06 Biogen Idec Ma Inc. Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
EP1697415A1 (de) 2003-11-12 2006-09-06 Biogen Idec MA Inc. Polypeptidvarianten, die an den neonatal-fc-receptor (fcrn) binden, dimere fc-bindende proteine und damit in zusammenhang stehende verfahren
WO2005113584A1 (en) * 2004-04-29 2005-12-01 Board Of Regents, University Of Texas System Methods and compositions comprising protein l immunoglobulin binding domains for cell-specific targeting
CN101534848B (zh) 2006-09-19 2013-07-17 亚洲大学校产学协力团 抗动物病毒的抗病毒剂
US10585098B2 (en) 2009-11-23 2020-03-10 The Johns Hopkins University Optimizing diagnostics for galactofuranose containing antigens
US10288611B2 (en) 2009-11-23 2019-05-14 The Johns Hopkins University Lateral flow device for diagnosing microbial infections
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
EP2565667A1 (de) 2011-08-31 2013-03-06 Friedrich-Alexander-Universität Erlangen-Nürnberg Ankunftsrichtungsschätzung mittels mit einem Wasserzeichen versehenen Audiosignalen und Mikrofonanordnungen
NZ718283A (en) 2013-09-25 2022-05-27 Cytomx Therapeutics Inc Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
WO2015095195A1 (en) 2013-12-16 2015-06-25 The Johns Hopkins University Interferon-gamma release assays for diagnosis of invasive fungal infections
AU2015210862B2 (en) 2014-01-31 2020-04-23 Cytomx Therapeutics, Inc Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
MA41374A (fr) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985002414A1 (en) * 1983-11-29 1985-06-06 Igen, Inc. Method of catalyzing chemical reactions
US5126258A (en) * 1984-09-07 1992-06-30 Scripps Clinic And Research Foundation Molecules with antibody combining sites that exhibit catalytic properties
US4900674A (en) * 1987-05-28 1990-02-13 Scripps Clinic And Research Foundation Antibody combining sites that exhibit amide or ester synthase activity
US5190865A (en) * 1988-11-18 1993-03-02 The Regents Of The University Of California Antibody-enhanced stereospecific hydrolyses
US5215889A (en) * 1988-11-18 1993-06-01 The Regents Of The University Of California Catalytic and reactive polypeptides and methods for their preparation and use
US5219732A (en) * 1989-09-05 1993-06-15 The Regents Of The University Of California Antibody-mediated cofactor-driven reactions
US5187086A (en) * 1990-01-26 1993-02-16 Scripps Clinic And Research Foundation Molecules with antibody combining sites that catalyze hydrolysis reactions through use of a charged hapten
SE9002212D0 (sv) * 1990-06-21 1990-06-21 Hightech Receptor Ab Igg binding protein
KR100334697B1 (ko) * 1991-08-05 2002-04-27 리차아드제이마세이 표적화된 촉매 단백질에 의해 활성화되는 선구 약제
IL104829A (en) * 1992-02-24 1999-04-11 Igen Inc Selection is based on a response to the expression and concentration of catalytic units
US5439812A (en) * 1992-04-08 1995-08-08 The Pennsylvania Research Corporation Antibodies catalyzing deamidation of proteins
SE9201331D0 (sv) * 1992-04-28 1992-04-28 Hightech Receptor C O Active Protein l och hybridproteiner daerav
GB9209804D0 (en) * 1992-05-07 1992-06-24 Health Lab Service Board Novel immunoglobulin binding proteins process for their production and recombinant dna molecules coding therefor
GB2326643B (en) * 1996-03-26 2000-09-27 Amrad Operations Pty Ltd Precursors of catalytic antibodies
AU731580B2 (en) * 1996-03-26 2001-04-05 Frank Koentgen Precursors of catalytic antibodies
US7253178B2 (en) * 2001-03-28 2007-08-07 Eisai Co., Ltd. Carboxylic acids
TWI311133B (en) * 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
WO2002098840A1 (fr) * 2001-06-04 2002-12-12 Eisai Co., Ltd. Derive de l'acide carboxylique et medicament comprenant un sel ou un ester dudit derive
EP1452521A4 (de) * 2001-08-17 2007-03-14 Eisai R&D Man Co Ltd Cyclische verbindung und ppar-agonist

Also Published As

Publication number Publication date
WO1999015563A9 (en) 1999-06-03
EP1015494A1 (de) 2000-07-05
GB0009758D0 (en) 2000-06-07
HK1029350A1 (en) 2001-03-30
WO1999015563A1 (en) 1999-04-01
ES2253824T3 (es) 2006-06-01
DE69832804D1 (de) 2006-01-19
AUPO930697A0 (en) 1997-10-09
US20030148484A1 (en) 2003-08-07
NZ515603A (en) 2003-04-29
EP1015494B1 (de) 2005-12-14
DE69832804T2 (de) 2006-08-10
ATE312845T1 (de) 2005-12-15
US20090269355A1 (en) 2009-10-29
CA2304365A1 (en) 1999-04-01
EP1015494A4 (de) 2001-12-12
NZ503454A (en) 2004-01-30
US6590080B1 (en) 2003-07-08
NZ524429A (en) 2004-06-25
GB2345694A (en) 2000-07-19
GB2345694B (en) 2002-07-17

Similar Documents

Publication Publication Date Title
DK1015494T3 (da) Fremgangsmåde til fremstilling af katalytiske antistoffer
BR0010806A (pt) Métodos e materiais para a sìntese de produtos orgânicos
MY162525A (en) Process for concentration of antibodies and therapeutic products thereof
HU9303023D0 (en) Peptide nucleicadis and method for producing them
FI942237A0 (fi) Lysosomaalientsyymin pilkkoamia kasvaintenvastaisia lääkeainekonjugaatteja
DK0853487T3 (da) Neutraliserende monoklonale antistoffer mod respiratorisk syncytial virus
DK0986644T3 (da) Fremstilling af erythropoietin ved endogen genaktivering med virale promotorer
TR200002731T2 (tr) Proteolitik antikorların indüktör ve inhibitörlerinin tanımlanması, kompozisyonları ve kullanımları için metotlar
EP1808180A3 (de) Modifiziertes GP 100 und Verwendung dafür
DE59912185D1 (de) Verwendung von hsp70 protein
KR970705408A (ko) 헤모필루스 부착 및 침투 단백질(haemophilus adherence and penetration proteins)
WO2004102198A3 (en) Selection of b cells with specificity of interest: method of preparation and use
GB2326643B (en) Precursors of catalytic antibodies
BR0212504A (pt) Materiais e métodos para vacina de células t autólogas
ATE458037T1 (de) Grosstechnisch geeigneter mikroorganismus
CO5650177A2 (es) Constructos geneticos y composiciones que comprenden rre y cte y usos de estos
ATE505550T1 (de) Fermentationsverfahren
WO2001030989A3 (en) Method for creating divergent populations of nucleic acid molecules and proteins
DK1001929T3 (da) Fremgangsmåde til fremstilling af 3-cyano-2,4-dihalogen-5-flour-benzoesyrer
ES2177762T3 (es) Procedimiento para producir cis-2-hidrixi-l-prolina.
ITMI910861A1 (it) Procedimento migliorato per la preparazione di polipeptidi maturi
Parikh Purification and characterization of hemorrhagic factor from Crotalus atrox (Western diamondback rattlesnake) venom by high performance liquid chromatography (HPLC) and production of monoclonal antibody.
HUT53593A (en) Process for producing optically active n-(terc butoxy-carbonyl)-o-benzyl-serine and n-(terc butoxy-carbonyl)-o-benzyl-treonine
MX9802766A (es) Vacuna contra la influenza.