DK1015494T3 - Fremgangsmåde til fremstilling af katalytiske antistoffer - Google Patents

Fremgangsmåde til fremstilling af katalytiske antistoffer

Info

Publication number
DK1015494T3
DK1015494T3 DK98943578T DK98943578T DK1015494T3 DK 1015494 T3 DK1015494 T3 DK 1015494T3 DK 98943578 T DK98943578 T DK 98943578T DK 98943578 T DK98943578 T DK 98943578T DK 1015494 T3 DK1015494 T3 DK 1015494T3
Authority
DK
Denmark
Prior art keywords
growth factor
present
factor precursor
catalytic antibodies
nucleic acid
Prior art date
Application number
DK98943578T
Other languages
English (en)
Inventor
Herbert Rudolf Treutlein
Gabriele Maria Suess
David Mathew Tarlinton
Frank Koentgen
Original Assignee
Frank Koentgen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frank Koentgen filed Critical Frank Koentgen
Application granted granted Critical
Publication of DK1015494T3 publication Critical patent/DK1015494T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK98943578T 1997-09-19 1998-09-18 Fremgangsmåde til fremstilling af katalytiske antistoffer DK1015494T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPO9306A AUPO930697A0 (en) 1997-09-19 1997-09-19 Catalytic antibodies and a method of producing same

Publications (1)

Publication Number Publication Date
DK1015494T3 true DK1015494T3 (da) 2006-05-01

Family

ID=3803589

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98943578T DK1015494T3 (da) 1997-09-19 1998-09-18 Fremgangsmåde til fremstilling af katalytiske antistoffer

Country Status (12)

Country Link
US (3) US6590080B1 (da)
EP (1) EP1015494B1 (da)
AT (1) ATE312845T1 (da)
AU (1) AUPO930697A0 (da)
CA (1) CA2304365A1 (da)
DE (1) DE69832804T2 (da)
DK (1) DK1015494T3 (da)
ES (1) ES2253824T3 (da)
GB (1) GB2345694B (da)
HK (1) HK1029350A1 (da)
NZ (3) NZ503454A (da)
WO (1) WO1999015563A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU731580B2 (en) * 1996-03-26 2001-04-05 Frank Koentgen Precursors of catalytic antibodies
KR20050071498A (ko) * 2002-09-18 2005-07-07 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 성장 호르몬 방출 호르몬 유사체
US7700097B2 (en) 2003-06-27 2010-04-20 Biogen Idec Ma Inc. Purification and preferential synthesis of binding molecules
EP2385069A3 (en) 2003-11-12 2012-05-30 Biogen Idec MA Inc. Neonatal Fc rReceptor (FcRn)- binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
WO2005113584A1 (en) * 2004-04-29 2005-12-01 Board Of Regents, University Of Texas System Methods and compositions comprising protein l immunoglobulin binding domains for cell-specific targeting
KR100890463B1 (ko) 2006-09-19 2009-03-26 성균관대학교산학협력단 동물 세포 감염 바이러스에 대한 항바이러스제
US10288611B2 (en) 2009-11-23 2019-05-14 The Johns Hopkins University Lateral flow device for diagnosing microbial infections
US10585098B2 (en) 2009-11-23 2020-03-10 The Johns Hopkins University Optimizing diagnostics for galactofuranose containing antigens
US9738707B2 (en) 2011-07-15 2017-08-22 Biogen Ma Inc. Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto
EP2565667A1 (en) 2011-08-31 2013-03-06 Friedrich-Alexander-Universität Erlangen-Nürnberg Direction of arrival estimation using watermarked audio signals and microphone arrays
AU2014324884B2 (en) * 2013-09-25 2020-03-26 Cytomx Therapeutics, Inc Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
WO2015095195A1 (en) 2013-12-16 2015-06-25 The Johns Hopkins University Interferon-gamma release assays for diagnosis of invasive fungal infections
DK3628328T3 (da) 2014-01-31 2022-12-05 Cytomx Therapeutics Inc Matriptase- og u-plasminogen-aktivatorsubstrater og andre spaltelige dele og fremgangsmåder til anvendelse deraf
MA41374A (fr) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985002414A1 (en) * 1983-11-29 1985-06-06 Igen, Inc. Method of catalyzing chemical reactions
US5126258A (en) * 1984-09-07 1992-06-30 Scripps Clinic And Research Foundation Molecules with antibody combining sites that exhibit catalytic properties
US4900674A (en) * 1987-05-28 1990-02-13 Scripps Clinic And Research Foundation Antibody combining sites that exhibit amide or ester synthase activity
US5190865A (en) * 1988-11-18 1993-03-02 The Regents Of The University Of California Antibody-enhanced stereospecific hydrolyses
US5215889A (en) * 1988-11-18 1993-06-01 The Regents Of The University Of California Catalytic and reactive polypeptides and methods for their preparation and use
US5219732A (en) * 1989-09-05 1993-06-15 The Regents Of The University Of California Antibody-mediated cofactor-driven reactions
US5187086A (en) * 1990-01-26 1993-02-16 Scripps Clinic And Research Foundation Molecules with antibody combining sites that catalyze hydrolysis reactions through use of a charged hapten
SE9002212D0 (sv) * 1990-06-21 1990-06-21 Hightech Receptor Ab Igg binding protein
KR100334696B1 (ko) * 1991-08-05 2002-04-27 리차아드제이마세이 표적화된 촉매 단백질에 의해 활성화되는 선구 약제
IL104829A (en) * 1992-02-24 1999-04-11 Igen Inc Selection is based on a response to the expression and concentration of catalytic units
US5439812A (en) * 1992-04-08 1995-08-08 The Pennsylvania Research Corporation Antibodies catalyzing deamidation of proteins
SE9201331D0 (sv) * 1992-04-28 1992-04-28 Hightech Receptor C O Active Protein l och hybridproteiner daerav
GB9209804D0 (en) * 1992-05-07 1992-06-24 Health Lab Service Board Novel immunoglobulin binding proteins process for their production and recombinant dna molecules coding therefor
EP0935612A4 (en) * 1996-03-26 2001-12-12 Amrad Operations Pty Ltd Precursors of catalytic antibodies
AU731580B2 (en) * 1996-03-26 2001-04-05 Frank Koentgen Precursors of catalytic antibodies
WO2002079162A1 (fr) * 2001-03-28 2002-10-10 Eisai Co., Ltd. Acides carboxyliques
TWI311133B (en) * 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
EP1394147A4 (en) * 2001-06-04 2007-10-24 Eisai R&D Man Co Ltd CARBOXYLENE DERIVATIVE AND A SALT OR AN ESTER CONTAINING MEDICINE
JPWO2003016265A1 (ja) * 2001-08-17 2004-12-02 エーザイ株式会社 環状化合物およびｐｐａｒアゴニスト

Also Published As

Publication number Publication date
NZ515603A (en) 2003-04-29
HK1029350A1 (en) 2001-03-30
ES2253824T3 (es) 2006-06-01
EP1015494A4 (en) 2001-12-12
NZ503454A (en) 2004-01-30
EP1015494B1 (en) 2005-12-14
US20030148484A1 (en) 2003-08-07
DE69832804T2 (de) 2006-08-10
GB0009758D0 (en) 2000-06-07
GB2345694A (en) 2000-07-19
GB2345694B (en) 2002-07-17
WO1999015563A1 (en) 1999-04-01
US6590080B1 (en) 2003-07-08
EP1015494A1 (en) 2000-07-05
ATE312845T1 (de) 2005-12-15
WO1999015563A9 (en) 1999-06-03
NZ524429A (en) 2004-06-25
AUPO930697A0 (en) 1997-10-09
DE69832804D1 (de) 2006-01-19
CA2304365A1 (en) 1999-04-01
US20090269355A1 (en) 2009-10-29

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