DK0981341T3 - Anvendelse af betulinsyrederivater til behandling og forebyggelse af melanom - Google Patents
Anvendelse af betulinsyrederivater til behandling og forebyggelse af melanomInfo
- Publication number
- DK0981341T3 DK0981341T3 DK98915378T DK98915378T DK0981341T3 DK 0981341 T3 DK0981341 T3 DK 0981341T3 DK 98915378 T DK98915378 T DK 98915378T DK 98915378 T DK98915378 T DK 98915378T DK 0981341 T3 DK0981341 T3 DK 0981341T3
- Authority
- DK
- Denmark
- Prior art keywords
- betulinic acid
- melanoma
- prevention
- treatment
- acid derivatives
- Prior art date
Links
- QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 title abstract 3
- 201000001441 melanoma Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- QGJZLNKBHJESQX-UHFFFAOYSA-N 3-Epi-Betulin-Saeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(=C)C)C5C4CCC3C21C QGJZLNKBHJESQX-UHFFFAOYSA-N 0.000 abstract 1
- CLOUCVRNYSHRCF-UHFFFAOYSA-N 3beta-Hydroxy-20(29)-Lupen-3,27-oic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C(O)=O)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C CLOUCVRNYSHRCF-UHFFFAOYSA-N 0.000 abstract 1
- DIZWSDNSTNAYHK-XGWVBXMLSA-N Betulinic acid Natural products CC(=C)[C@@H]1C[C@H]([C@H]2CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(=O)O DIZWSDNSTNAYHK-XGWVBXMLSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 abstract 1
- PZXJOHSZQAEJFE-UHFFFAOYSA-N dihydrobetulinic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(C)C)C5C4CCC3C21C PZXJOHSZQAEJFE-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- MQYXUWHLBZFQQO-UHFFFAOYSA-N nepehinol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C MQYXUWHLBZFQQO-UHFFFAOYSA-N 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/858,011 US5869535A (en) | 1995-03-21 | 1997-05-16 | Method and composition for selectively inhibiting melanoma |
PCT/US1998/007007 WO1998051293A1 (fr) | 1997-05-16 | 1998-04-06 | Utilisation de derives de l'acide betulinique pour le traitement et la prevention des melanomes |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0981341T3 true DK0981341T3 (da) | 2003-09-22 |
Family
ID=25327234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98915378T DK0981341T3 (da) | 1997-05-16 | 1998-04-06 | Anvendelse af betulinsyrederivater til behandling og forebyggelse af melanom |
Country Status (9)
Country | Link |
---|---|
US (4) | US5869535A (fr) |
EP (2) | EP1266658A3 (fr) |
AT (1) | ATE242632T1 (fr) |
CA (1) | CA2289686A1 (fr) |
DE (1) | DE69815527T2 (fr) |
DK (1) | DK0981341T3 (fr) |
ES (1) | ES2201478T3 (fr) |
PT (1) | PT981341E (fr) |
WO (1) | WO1998051293A1 (fr) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5962527A (en) * | 1995-03-21 | 1999-10-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for treating cancers |
US6228850B1 (en) * | 1997-09-30 | 2001-05-08 | Dabur Research Foundation | Antiangiogenic activity of betulinic acid and its derivatives |
US6670345B1 (en) | 1997-09-30 | 2003-12-30 | Dabur Research Foundation | Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid |
US6048847A (en) * | 1997-09-30 | 2000-04-11 | Dabur Research Foundation | Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this |
US6214814B1 (en) * | 1998-03-18 | 2001-04-10 | Dabur Research Foundation | Use of betulinic acid derivatives for inhibiting cancer growth |
TWI227136B (en) * | 1998-05-21 | 2005-02-01 | Smithkline Beecham Corp | Novel pharmaceutical composition for the prevention and/or treatment of cancer |
US6369109B1 (en) | 1998-10-28 | 2002-04-09 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor |
AU766599B2 (en) * | 1998-11-18 | 2003-10-16 | Dabur Pharma Ltd. | Novel betulinic acid derivatives, processes for preparing such derivatives and its use as cancer growth inhibitors |
US6303589B1 (en) | 1998-12-08 | 2001-10-16 | Micro Flo Company | Pentacyclic triterpenes |
AU780148B2 (en) * | 1999-09-09 | 2005-03-03 | Dabur Research Foundation | Novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis |
GB2362648A (en) * | 2000-05-23 | 2001-11-28 | Univerzita Palackeho V Olomouc | Triterpenoid derivatives |
EP1309605A1 (fr) | 2000-08-18 | 2003-05-14 | The Board Of Trustees Of The University Of Illinois | Promedicaments de derives de l'acide betulinique pour le traitement du cancer et du vih |
KR100445683B1 (ko) * | 2001-05-02 | 2004-08-21 | 김송배 | 신규의 루판 유도체, 그의 제조방법 및 그를 포함하는항암제 |
US7488722B2 (en) * | 2001-05-11 | 2009-02-10 | University Of Ottawa | Anxiolytic Marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods |
JPWO2003057224A1 (ja) * | 2001-12-28 | 2005-08-25 | 日清オイリオグループ株式会社 | アポトーシス誘導剤 |
US7026305B2 (en) * | 2003-04-14 | 2006-04-11 | Meharry Medical College | Anti-HIV agents with dual sites of action |
US20080227762A1 (en) * | 2004-03-02 | 2008-09-18 | Wisconsin Alumni Research Foundation | Lupeol anti-tumor agent and uses thereof |
US20060019934A1 (en) * | 2004-05-20 | 2006-01-26 | Saxena Brij B | Anti-HIV-1 activity of betulinol derivatives |
EP1786433A4 (fr) | 2004-09-10 | 2008-02-27 | Brij B Saxena | Derives de betulinol utilises en tant qu'agents anti-vih |
US20060252733A1 (en) * | 2005-04-07 | 2006-11-09 | Novelix Pharmaceuticals, Inc. | Betulin, betulin derivatives, betulinic acid and betulinic acid derivatives as novel therapeutics in the treatment of disease of lipid and/or glucose metabolism |
CA2609280A1 (fr) * | 2005-06-22 | 2007-01-04 | Myriad Genetics, Inc. | Composes antiviraux |
ZA200805703B (en) * | 2005-12-16 | 2009-10-28 | Panacos Pharmaceuticals Inc | Preparation of pharmaceutical salts of 3-0-(3',3'-dimethyl-succinyl) betulinic acid |
DE102006008074B4 (de) * | 2006-02-22 | 2013-08-14 | RUHR-UNIVERSITäT BOCHUM | Behandlung von Krebs mit Geruchsrezeptor-Liganden |
FI121468B (fi) * | 2006-06-07 | 2010-11-30 | Valtion Teknillinen | Betuliiniperäiset yhdisteet antimikrobisina aineina |
US20090105203A1 (en) * | 2006-10-16 | 2009-04-23 | Myriad Genetics, Incorporated | Compounds for treating viral infections |
US9276602B1 (en) * | 2009-12-16 | 2016-03-01 | Syntropy Systems, Llc | Conversion of a discrete-time quantized signal into a continuous-time, continuously variable signal |
WO2011153315A1 (fr) | 2010-06-04 | 2011-12-08 | Bristol-Myers Squibb Company | Dérivés d'acide bétulinique modifiés en c-3, utilisés comme inhibiteurs de maturation du vih |
EA026140B1 (ru) | 2010-06-04 | 2017-03-31 | Бристол-Майерс Сквибб Компани | С-28 амиды модифицированных производных с-3 бетулиновой кислоты в качестве ингибиторов созревания вич |
MY162186A (en) | 2011-01-31 | 2017-05-31 | Viiv Healthcare Uk (No 4) Ltd | C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity |
HUE026371T2 (en) | 2011-01-31 | 2016-05-30 | Bristol Myers Squibb Co | C-28 amines from modified C-3 betulinic acid derivatives as anti-HIV matrices |
EA023463B1 (ru) | 2011-09-21 | 2016-06-30 | Бристол-Майерс Сквибб Компани | Производные бетулиновой кислоты с противовирусной активностью |
US8906889B2 (en) | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
US8889854B2 (en) | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
US9808011B2 (en) | 2014-12-15 | 2017-11-07 | Biovectra Inc. | Pentacyclic triterpene compounds and uses thereof |
PL227790B1 (pl) | 2015-08-13 | 2018-01-31 | Slaski Univ Medyczny W Katowicach | Fosfoniany acetylenowych pochodnych betuliny o działaniu przeciwnowotworowym, sposób ich wytwarzania i zastosowanie. |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01143832A (ja) * | 1987-12-01 | 1989-06-06 | Toa Nenryo Kogyo Kk | 制癌剤 |
FR2683531B1 (fr) * | 1991-11-13 | 1993-12-31 | Rhone Poulenc Rorer Sa | Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent. |
FR2705097B1 (fr) * | 1993-05-11 | 1995-08-04 | Rhone Poulenc Rorer Sa | Nouveaux dérivés du lupane, leur préparation et les compositions pharmaceutiques qui les contiennent. |
US5643884A (en) * | 1993-08-09 | 1997-07-01 | Glycomed Incorporated | Lupane triterpenoid derivatives |
US5658947A (en) * | 1995-03-21 | 1997-08-19 | Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma using betalinic acid |
US5962527A (en) * | 1995-03-21 | 1999-10-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for treating cancers |
US5679828A (en) * | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
DE19532006A1 (de) * | 1995-08-31 | 1997-03-06 | Thomas Samland | Medizinisches bzw. kosmetisches Präparat zur Vermeidung bzw. Abbau von Hautkrebs |
EP0902685A1 (fr) * | 1997-01-24 | 1999-03-24 | Marigen S.A. | Ultramicro-emulsions de concentres spontanement dispersibles renfermant des esters de triterpenes pentacycliques a activite antitumorale, antivirale et antiparasitaire |
AU766599B2 (en) | 1998-11-18 | 2003-10-16 | Dabur Pharma Ltd. | Novel betulinic acid derivatives, processes for preparing such derivatives and its use as cancer growth inhibitors |
EP1189607A2 (fr) | 1999-04-07 | 2002-03-27 | Washington State University Research Foundation | Activite anti-tumeur de derives de vitamine e, de cholesterol, de taxol et d'acide betulinique |
WO2002009719A1 (fr) | 2000-07-31 | 2002-02-07 | The Nisshin Oillio, Ltd. | Agents antitumoraux |
-
1997
- 1997-05-16 US US08/858,011 patent/US5869535A/en not_active Expired - Fee Related
-
1998
- 1998-04-06 AT AT98915378T patent/ATE242632T1/de not_active IP Right Cessation
- 1998-04-06 ES ES98915378T patent/ES2201478T3/es not_active Expired - Lifetime
- 1998-04-06 EP EP02019173A patent/EP1266658A3/fr not_active Withdrawn
- 1998-04-06 DE DE69815527T patent/DE69815527T2/de not_active Expired - Fee Related
- 1998-04-06 DK DK98915378T patent/DK0981341T3/da active
- 1998-04-06 EP EP98915378A patent/EP0981341B1/fr not_active Expired - Lifetime
- 1998-04-06 CA CA002289686A patent/CA2289686A1/fr not_active Abandoned
- 1998-04-06 WO PCT/US1998/007007 patent/WO1998051293A1/fr active IP Right Grant
- 1998-04-06 PT PT98915378T patent/PT981341E/pt unknown
- 1998-11-10 US US09/189,698 patent/US6225353B1/en not_active Expired - Fee Related
-
2000
- 2000-08-09 US US09/635,385 patent/US6495600B1/en not_active Expired - Fee Related
-
2002
- 2002-12-12 US US10/317,361 patent/US7414042B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0981341B1 (fr) | 2003-06-11 |
US5869535A (en) | 1999-02-09 |
EP1266658A3 (fr) | 2004-05-26 |
WO1998051293A1 (fr) | 1998-11-19 |
PT981341E (pt) | 2003-10-31 |
DE69815527D1 (de) | 2003-07-17 |
US7414042B2 (en) | 2008-08-19 |
EP1266658A2 (fr) | 2002-12-18 |
US20030181429A1 (en) | 2003-09-25 |
DE69815527T2 (de) | 2004-05-13 |
EP0981341A1 (fr) | 2000-03-01 |
US6225353B1 (en) | 2001-05-01 |
CA2289686A1 (fr) | 1998-11-19 |
ATE242632T1 (de) | 2003-06-15 |
US6495600B1 (en) | 2002-12-17 |
ES2201478T3 (es) | 2004-03-16 |
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