DK0975631T3 - Derivater af 5-aryl-3-(8-azabicyclo[3.2.1]oct-3-yl)-1,3,4-oxadiazol-2(3H)-on som ligander til 5-HT4-receptorerne - Google Patents

Derivater af 5-aryl-3-(8-azabicyclo[3.2.1]oct-3-yl)-1,3,4-oxadiazol-2(3H)-on som ligander til 5-HT4-receptorerne

Info

Publication number
DK0975631T3
DK0975631T3 DK98920622T DK98920622T DK0975631T3 DK 0975631 T3 DK0975631 T3 DK 0975631T3 DK 98920622 T DK98920622 T DK 98920622T DK 98920622 T DK98920622 T DK 98920622T DK 0975631 T3 DK0975631 T3 DK 0975631T3
Authority
DK
Denmark
Prior art keywords
oxadiazol
azabicyclo
ligands
receptors
oct
Prior art date
Application number
DK98920622T
Other languages
Danish (da)
English (en)
Inventor
Alistair Lochead
Alain Nedelec
Axelle Samson
Thierry Gallet
Samir Jegham
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Application granted granted Critical
Publication of DK0975631T3 publication Critical patent/DK0975631T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK98920622T 1997-04-18 1998-04-15 Derivater af 5-aryl-3-(8-azabicyclo[3.2.1]oct-3-yl)-1,3,4-oxadiazol-2(3H)-on som ligander til 5-HT4-receptorerne DK0975631T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9704802A FR2762316B1 (fr) 1997-04-18 1997-04-18 Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
PCT/FR1998/000754 WO1998047898A1 (fr) 1997-04-18 1998-04-15 Derives de 5-aryl-3-(8-azabicyclo(3.2.2)oct-3-yl)-1,3,4-oxadiazol-2(3h)-one en tant que ligands des recepteurs 5-ht4

Publications (1)

Publication Number Publication Date
DK0975631T3 true DK0975631T3 (da) 2002-01-28

Family

ID=9506076

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98920622T DK0975631T3 (da) 1997-04-18 1998-04-15 Derivater af 5-aryl-3-(8-azabicyclo[3.2.1]oct-3-yl)-1,3,4-oxadiazol-2(3H)-on som ligander til 5-HT4-receptorerne

Country Status (32)

Country Link
US (1) US6255319B1 (no)
EP (1) EP0975631B1 (no)
JP (1) JP2001521542A (no)
KR (1) KR20010006452A (no)
CN (1) CN1260794A (no)
AR (1) AR012458A1 (no)
AT (1) ATE206424T1 (no)
AU (1) AU742666B2 (no)
BG (1) BG64053B1 (no)
BR (1) BR9808926A (no)
CA (1) CA2286106A1 (no)
CO (1) CO4750656A1 (no)
CZ (1) CZ289154B6 (no)
DE (1) DE69801905T2 (no)
DK (1) DK0975631T3 (no)
EE (1) EE03769B1 (no)
ES (1) ES2165162T3 (no)
FR (1) FR2762316B1 (no)
HU (1) HUP0002456A3 (no)
IL (1) IL132352A0 (no)
NO (1) NO995040L (no)
NZ (1) NZ500396A (no)
PL (1) PL186894B1 (no)
PT (1) PT975631E (no)
RU (1) RU2186066C2 (no)
SI (1) SI0975631T1 (no)
SK (1) SK283441B6 (no)
TR (1) TR199902600T2 (no)
TW (1) TW502005B (no)
UA (1) UA57071C2 (no)
WO (1) WO1998047898A1 (no)
ZA (1) ZA983257B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0211230D0 (en) * 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
AU2004226452B2 (en) * 2003-03-26 2008-07-24 Merck Sharp & Dohme Corp. Bicyclic piperidine derivatives as melanocortin-4 receptor agonists
JP2007511559A (ja) * 2003-11-18 2007-05-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 固形医薬製剤
WO2005123718A2 (en) 2004-06-15 2005-12-29 Pfizer Japan Inc. Benzimidazolone carboxylic acid derivatives
US7737163B2 (en) 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
SE532388C2 (sv) * 2008-03-14 2010-01-12 Tetra Laval Holdings & Finance Förpackningslaminat och -behållare med två separata gasbarriärskikt samt metod för deras framställning
JP6348568B2 (ja) * 2013-03-15 2018-06-27 モンサント テクノロジー エルエルシー 線虫害虫防除のためのｎ−，ｃ−二置換アゾール
GB201814151D0 (en) * 2018-08-31 2018-10-17 Ucl Business Plc Compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2135414T3 (es) * 1991-09-12 1999-11-01 Smithkline Beecham Plc Antagonistas del receptor 5-ht4.
DE69319939T2 (de) * 1992-02-04 1999-02-18 Eisai Co., Ltd., Tokio/Tokyo Aminobenzoesäure Derivate
AU667874B2 (en) * 1992-02-06 1996-04-18 Smithkline Beecham Plc Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
SK282335B6 (sk) * 1995-11-09 2002-01-07 Sanofi-Synthelabo Deriváty 5-fenyl-3-(piperidin-4-yl)-1,3,4,-oxadiazol-2(3H)-ónu, spôsob ich prípravy a farmaceutický prostriedok, ktorý ich obsahuje

Also Published As

Publication number Publication date
SI0975631T1 (en) 2002-06-30
DE69801905D1 (de) 2001-11-08
EP0975631B1 (fr) 2001-10-04
PT975631E (pt) 2002-03-28
AU742666B2 (en) 2002-01-10
CN1260794A (zh) 2000-07-19
JP2001521542A (ja) 2001-11-06
DE69801905T2 (de) 2002-07-04
FR2762316A1 (fr) 1998-10-23
BG103810A (en) 2000-06-30
ES2165162T3 (es) 2002-03-01
CZ289154B6 (cs) 2001-11-14
CZ364199A3 (cs) 2000-03-15
NO995040D0 (no) 1999-10-15
KR20010006452A (ko) 2001-01-26
UA57071C2 (uk) 2003-06-16
ZA983257B (en) 1998-10-19
BR9808926A (pt) 2000-08-01
EP0975631A1 (fr) 2000-02-02
AR012458A1 (es) 2000-10-18
ATE206424T1 (de) 2001-10-15
AU7341598A (en) 1998-11-13
PL186894B1 (pl) 2004-03-31
EE03769B1 (et) 2002-06-17
WO1998047898A1 (fr) 1998-10-29
FR2762316B1 (fr) 1999-12-17
BG64053B1 (bg) 2003-11-28
HUP0002456A2 (hu) 2000-12-28
IL132352A0 (en) 2001-03-19
RU2186066C2 (ru) 2002-07-27
SK283441B6 (sk) 2003-07-01
EE9900487A (et) 2000-06-15
NZ500396A (en) 2001-04-27
TR199902600T2 (xx) 2000-03-21
HUP0002456A3 (en) 2001-03-28
PL336315A1 (en) 2000-06-19
SK142699A3 (en) 2000-05-16
TW502005B (en) 2002-09-11
US6255319B1 (en) 2001-07-03
NO995040L (no) 1999-12-16
CO4750656A1 (es) 1999-03-31
CA2286106A1 (en) 1998-10-29

Similar Documents

Publication Publication Date Title
NO982092L (no) 5-fenyl-3-(piperidin-4-yl)-1,3,4-oksadiazol-2(3H)-on-derivater, for anvendelse som 5-HT4 eller H3 reseptorligander
ZA988078B (en) Substituted oxindole derivatives.
EE9900027A (et) Asendatud triasolopüridasiini derivaadid GABA retseptorite ligandidena
DK0901470T3 (da) Indolderivater egnede som endothelinreceptorantagonister
DK0630376T3 (da) Kondenserede indolderivater som 5-HT4-receptorantagonister
AU6343998A (en) Constitutively activated serotonin receptors
HK1028399A1 (en) Cyclopentene derivatives useful as antagonists of the motilin receptor.
DK0975631T3 (da) Derivater af 5-aryl-3-(8-azabicyclo[3.2.1]oct-3-yl)-1,3,4-oxadiazol-2(3H)-on som ligander til 5-HT4-receptorerne
TR199901381A3 (tr) Diaza-spiro[3,5]nonan türevleri.
NO994106D0 (no) Oksazolidiner som 5-HT2A-antagonister
DE69725182D1 (de) 5H PYRROLO[2,1-c][1,4]BENZODIAZEPIN-3-CARBOXAMIDDERIVATE
AU2095099A (en) Phthalimide-piperidine, -pyrrolidine and -azepine derivatives, their preparationand their use as muscarinic receptor (ant-)agonists
NO953387D0 (no) Anvendelsen av 2H-1,2,4-benzotiadiazin 3 (4H)-on 1,1-dioksydderivater som ikke-kompetitive NMDA-reseptor-antagonister
DK0885222T3 (da) Heterocycliske ergolinderivater som 5HT1A-receptorligander
ZA200203085B (en) Process for the synthesis of (3AS)-5,5-DIOXO-2,3,3A,4-tetrahydro-1H-pyrrolo [2,1-C][1,2,4]benzothiadiazine.
DK444389A (da) Makrocycliske forbindelser, fremgangsmaade til deres fremstilling samt deres anvendelse som mikrobicider
DK1133494T3 (da) 8-Azabicyclo[3.2.1]oct-2-en-derivater
AU1449997A (en) Diazabicyclo-octane derivatives as 5-ht receptor ligands
TR199700044U (tr) Renkli otomatik kase mekanizmasi.
ZA9600758D (en) Idole derivatives as 5-ht receptor antagonist.
AU2178299A (en) 8-azabicyclo(3.2.1)oct-2-ene derivatives as pesticides
NL1010152A1 (nl) Decoratieve lamphouderstructuur voor de kerst.
ITBO990142A0 (it) Tornio automatico monomandrino perfezionato .