DK0883610T3 - Process for the preparation of 1,4,7,10-tetraazacyclododecane and derivatives thereof - Google Patents

Process for the preparation of 1,4,7,10-tetraazacyclododecane and derivatives thereof

Info

Publication number
DK0883610T3
DK0883610T3 DK96946361T DK96946361T DK0883610T3 DK 0883610 T3 DK0883610 T3 DK 0883610T3 DK 96946361 T DK96946361 T DK 96946361T DK 96946361 T DK96946361 T DK 96946361T DK 0883610 T3 DK0883610 T3 DK 0883610T3
Authority
DK
Denmark
Prior art keywords
tetraazacyclododecane
derivatives
preparation
cyclotetramerization
benzylaziridine
Prior art date
Application number
DK96946361T
Other languages
Danish (da)
Inventor
Orlin Petrov
Annette Prelle
Klaus Graske
Klaus Nickisch
Bernd Raduechel
Johannes Platzek
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0883610T3 publication Critical patent/DK0883610T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention concerns a process for preparing 1,4,7,10-tetraazacyclododecane (cyclene) and its derivatives on an industrial scale by the cyclotetramerization of benzylaziridine prepared in situ.
DK96946361T 1996-02-26 1997-02-26 Process for the preparation of 1,4,7,10-tetraazacyclododecane and derivatives thereof DK0883610T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19608307A DE19608307C1 (en) 1996-02-26 1996-02-26 Process for the preparation of 1,4,7,10-tetraazacyclododecane and its derivatives
PCT/EP1997/000927 WO1997031905A1 (en) 1996-02-26 1997-02-26 Process for preparing 1,4,7,10-tetraazacyclododecane and its derivatives

Publications (1)

Publication Number Publication Date
DK0883610T3 true DK0883610T3 (en) 2000-09-25

Family

ID=7787168

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96946361T DK0883610T3 (en) 1996-02-26 1997-02-26 Process for the preparation of 1,4,7,10-tetraazacyclododecane and derivatives thereof

Country Status (21)

Country Link
EP (1) EP0883610B1 (en)
JP (2) JP4745469B2 (en)
KR (1) KR100453668B1 (en)
CN (1) CN1081186C (en)
AT (1) ATE194602T1 (en)
AU (1) AU717720B2 (en)
CA (1) CA2247265C (en)
CZ (1) CZ290128B6 (en)
DE (2) DE19608307C1 (en)
DK (1) DK0883610T3 (en)
ES (1) ES2148837T3 (en)
GR (1) GR3034468T3 (en)
HK (1) HK1018618A1 (en)
IL (1) IL125419A (en)
NO (1) NO310870B1 (en)
NZ (1) NZ331520A (en)
PL (1) PL185927B1 (en)
PT (1) PT883610E (en)
SK (1) SK281972B6 (en)
WO (1) WO1997031905A1 (en)
ZA (1) ZA971672B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19608307C1 (en) * 1996-02-26 1997-08-28 Schering Ag Process for the preparation of 1,4,7,10-tetraazacyclododecane and its derivatives
CZ2005653A3 (en) * 2005-10-17 2007-01-10 Azacycles S. R. O. Process for preparing 1,4,7,10-tetraazacyclododecane and N-acyl derivatives thereof
DE102009057274B4 (en) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrol preparation using trioxobicyclo-octane
DE102010013833A1 (en) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Producing gadolinium complex of N-(hydroxymethyl-dihydroxypropyl)-triscarboxymethyl-tetraazacyclododecane useful as magnetic resonance imaging contrast agent, comprises e.g. reacting cyclic compound with dimethylformamide dimethylacetal
CN101845112B (en) * 2010-06-02 2011-09-14 华东理工大学 Preparation method of high-flexibility nuclear magnetic resonance imaging contrast agents based on high molecular nanometer particles
DE102010023105A1 (en) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrol preparation in a one-pot process using DMF-acetal and N-methylimidazole
EA201600272A1 (en) 2011-04-21 2016-12-30 Байер Интеллектчуал Проперти Гмбх GETTING HADOBUTROL OF HIGH PURITY
KR102067551B1 (en) * 2018-04-12 2020-01-17 (주) 에프엔지리서치 Compounds for remediating the contaminated soil or water
CN108794417A (en) * 2018-08-04 2018-11-13 许昌恒生制药有限公司 A kind of preparation method of medical diagnosis contrast agent intermediate
EP4335461A1 (en) 2022-09-09 2024-03-13 Bayer AG Combinations of contrast agents
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3828023A (en) * 1971-09-13 1974-08-06 Dow Chemical Co Process for preparing cyclic oligomers of n-substituted aziridines
US6693190B1 (en) * 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
EP0813523A2 (en) * 1995-03-10 1997-12-29 Nycomed Salutar, Inc. Preparation of n-arylmethyl aziridine derivatives, 1,4,7,10-tetraazacyclododecane derivatives obtained therefrom and n-arylmethyl-ethanol-amine sulphonate esters as intermediates
DE19608307C1 (en) * 1996-02-26 1997-08-28 Schering Ag Process for the preparation of 1,4,7,10-tetraazacyclododecane and its derivatives

Also Published As

Publication number Publication date
KR100453668B1 (en) 2004-12-16
NO983901D0 (en) 1998-08-25
CN1211975A (en) 1999-03-24
JP2000505467A (en) 2000-05-09
WO1997031905A1 (en) 1997-09-04
CZ272198A3 (en) 2000-02-16
CA2247265A1 (en) 1997-09-04
AU717720B2 (en) 2000-03-30
SK117298A3 (en) 1999-01-11
PT883610E (en) 2000-10-31
EP0883610B1 (en) 2000-07-12
HK1018618A1 (en) 1999-12-30
AU1877297A (en) 1997-09-16
EP0883610A1 (en) 1998-12-16
NO983901L (en) 1998-08-25
IL125419A0 (en) 1999-03-12
GR3034468T3 (en) 2000-12-29
CA2247265C (en) 2005-06-21
JP2009185077A (en) 2009-08-20
KR19990087248A (en) 1999-12-15
PL185927B1 (en) 2003-09-30
PL328468A1 (en) 1999-02-01
JP4745469B2 (en) 2011-08-10
ZA971672B (en) 1997-08-29
CN1081186C (en) 2002-03-20
DE19608307C1 (en) 1997-08-28
SK281972B6 (en) 2001-09-11
ATE194602T1 (en) 2000-07-15
DE59702009D1 (en) 2000-08-17
IL125419A (en) 2001-01-11
NO310870B1 (en) 2001-09-10
NZ331520A (en) 2000-01-28
CZ290128B6 (en) 2002-06-12
ES2148837T3 (en) 2000-10-16

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