CA2247265A1 - Process for preparing 1,4,7,10-tetraazacyclododecane and its derivatives - Google Patents

Process for preparing 1,4,7,10-tetraazacyclododecane and its derivatives

Info

Publication number
CA2247265A1
CA2247265A1 CA002247265A CA2247265A CA2247265A1 CA 2247265 A1 CA2247265 A1 CA 2247265A1 CA 002247265 A CA002247265 A CA 002247265A CA 2247265 A CA2247265 A CA 2247265A CA 2247265 A1 CA2247265 A1 CA 2247265A1
Authority
CA
Canada
Prior art keywords
tetraazacyclododecane
derivatives
preparing
cyclotetramerization
benzylaziridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002247265A
Other languages
French (fr)
Other versions
CA2247265C (en
Inventor
Orlin Petrov
Annette Prelle
Klaus Graske
Klaus Nickisch
Bernd Raduchel
Johannes Platzek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Intellectual Property GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2247265A1 publication Critical patent/CA2247265A1/en
Application granted granted Critical
Publication of CA2247265C publication Critical patent/CA2247265C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention concerns a process for preparing 1,4,7,10-tetraazacyclododecane (cyclene) and its derivatives on an industrial scale by the cyclotetramerization of benzylaziridine prepared in situ.
CA002247265A 1996-02-26 1997-02-26 Process for preparing 1,4,7,10-tetraazacyclododecane and its derivatives Expired - Lifetime CA2247265C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19608307.9 1996-02-26
DE19608307A DE19608307C1 (en) 1996-02-26 1996-02-26 Process for the preparation of 1,4,7,10-tetraazacyclododecane and its derivatives
PCT/EP1997/000927 WO1997031905A1 (en) 1996-02-26 1997-02-26 Process for preparing 1,4,7,10-tetraazacyclododecane and its derivatives

Publications (2)

Publication Number Publication Date
CA2247265A1 true CA2247265A1 (en) 1997-09-04
CA2247265C CA2247265C (en) 2005-06-21

Family

ID=7787168

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002247265A Expired - Lifetime CA2247265C (en) 1996-02-26 1997-02-26 Process for preparing 1,4,7,10-tetraazacyclododecane and its derivatives

Country Status (20)

Country Link
EP (1) EP0883610B1 (en)
JP (2) JP4745469B2 (en)
KR (1) KR100453668B1 (en)
CN (1) CN1081186C (en)
AT (1) ATE194602T1 (en)
AU (1) AU717720B2 (en)
CA (1) CA2247265C (en)
CZ (1) CZ290128B6 (en)
DE (2) DE19608307C1 (en)
DK (1) DK0883610T3 (en)
ES (1) ES2148837T3 (en)
GR (1) GR3034468T3 (en)
IL (1) IL125419A (en)
NO (1) NO310870B1 (en)
NZ (1) NZ331520A (en)
PL (1) PL185927B1 (en)
PT (1) PT883610E (en)
SK (1) SK281972B6 (en)
WO (1) WO1997031905A1 (en)
ZA (1) ZA971672B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19608307C1 (en) * 1996-02-26 1997-08-28 Schering Ag Process for the preparation of 1,4,7,10-tetraazacyclododecane and its derivatives
CZ297577B6 (en) * 2005-10-17 2007-01-10 Azacycles S. R. O. Process for preparing 1,4,7,10-tetraazacyclododecane and N-acyl derivatives thereof
DE102009057274B4 (en) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrol preparation using trioxobicyclo-octane
DE102010013833A1 (en) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Producing gadolinium complex of N-(hydroxymethyl-dihydroxypropyl)-triscarboxymethyl-tetraazacyclododecane useful as magnetic resonance imaging contrast agent, comprises e.g. reacting cyclic compound with dimethylformamide dimethylacetal
CN101845112B (en) * 2010-06-02 2011-09-14 华东理工大学 Preparation method of high-flexibility nuclear magnetic resonance imaging contrast agents based on high molecular nanometer particles
DE102010023105A1 (en) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrol preparation in a one-pot process using DMF-acetal and N-methylimidazole
PT2896405T (en) 2011-04-21 2020-03-31 Bayer Ip Gmbh Preparation of high-purity gadobutrol
KR102067551B1 (en) * 2018-04-12 2020-01-17 (주) 에프엔지리서치 Compounds for remediating the contaminated soil or water
CN108794417A (en) * 2018-08-04 2018-11-13 许昌恒生制药有限公司 A kind of preparation method of medical diagnosis contrast agent intermediate
EP4335461A1 (en) 2022-09-09 2024-03-13 Bayer AG Combinations of contrast agents
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3828023A (en) * 1971-09-13 1974-08-06 Dow Chemical Co Process for preparing cyclic oligomers of n-substituted aziridines
US6693190B1 (en) * 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
EP0813523A2 (en) * 1995-03-10 1997-12-29 Nycomed Salutar, Inc. Preparation of n-arylmethyl aziridine derivatives, 1,4,7,10-tetraazacyclododecane derivatives obtained therefrom and n-arylmethyl-ethanol-amine sulphonate esters as intermediates
DE19608307C1 (en) * 1996-02-26 1997-08-28 Schering Ag Process for the preparation of 1,4,7,10-tetraazacyclododecane and its derivatives

Also Published As

Publication number Publication date
AU1877297A (en) 1997-09-16
JP4745469B2 (en) 2011-08-10
CA2247265C (en) 2005-06-21
NO983901L (en) 1998-08-25
ES2148837T3 (en) 2000-10-16
HK1018618A1 (en) 1999-12-30
CZ272198A3 (en) 2000-02-16
DE59702009D1 (en) 2000-08-17
JP2000505467A (en) 2000-05-09
WO1997031905A1 (en) 1997-09-04
EP0883610A1 (en) 1998-12-16
PL185927B1 (en) 2003-09-30
SK117298A3 (en) 1999-01-11
CZ290128B6 (en) 2002-06-12
PL328468A1 (en) 1999-02-01
CN1081186C (en) 2002-03-20
KR19990087248A (en) 1999-12-15
SK281972B6 (en) 2001-09-11
EP0883610B1 (en) 2000-07-12
GR3034468T3 (en) 2000-12-29
IL125419A (en) 2001-01-11
ZA971672B (en) 1997-08-29
CN1211975A (en) 1999-03-24
NO310870B1 (en) 2001-09-10
AU717720B2 (en) 2000-03-30
IL125419A0 (en) 1999-03-12
JP2009185077A (en) 2009-08-20
DK0883610T3 (en) 2000-09-25
NO983901D0 (en) 1998-08-25
NZ331520A (en) 2000-01-28
PT883610E (en) 2000-10-31
DE19608307C1 (en) 1997-08-28
KR100453668B1 (en) 2004-12-16
ATE194602T1 (en) 2000-07-15

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170227