DK0850304T3 - Cerebellum-deriveret-vækstfaktorer og brug relateret dertil - Google Patents

Cerebellum-deriveret-vækstfaktorer og brug relateret dertil

Info

Publication number
DK0850304T3
DK0850304T3 DK96932981T DK96932981T DK0850304T3 DK 0850304 T3 DK0850304 T3 DK 0850304T3 DK 96932981 T DK96932981 T DK 96932981T DK 96932981 T DK96932981 T DK 96932981T DK 0850304 T3 DK0850304 T3 DK 0850304T3
Authority
DK
Denmark
Prior art keywords
cerebellum
growth factors
derived growth
use related
cdgf
Prior art date
Application number
DK96932981T
Other languages
Danish (da)
English (en)
Inventor
Han Chang
Original Assignee
Harvard College
Trustees Of Leland S Stanford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Trustees Of Leland S Stanford filed Critical Harvard College
Application granted granted Critical
Publication of DK0850304T3 publication Critical patent/DK0850304T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Fats And Perfumes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK96932981T 1995-09-08 1996-09-09 Cerebellum-deriveret-vækstfaktorer og brug relateret dertil DK0850304T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/525,864 US5912326A (en) 1995-09-08 1995-09-08 Cerebellum-derived growth factors
PCT/US1996/014484 WO1997009425A1 (fr) 1995-09-08 1996-09-09 Facteurs de croissance derives du cervelet, et usages qui y sont lies

Publications (1)

Publication Number Publication Date
DK0850304T3 true DK0850304T3 (da) 2008-09-29

Family

ID=24094914

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96932981T DK0850304T3 (da) 1995-09-08 1996-09-09 Cerebellum-deriveret-vækstfaktorer og brug relateret dertil

Country Status (12)

Country Link
US (1) US5912326A (fr)
EP (1) EP0850304B1 (fr)
JP (2) JP4642943B2 (fr)
KR (1) KR19990044527A (fr)
AT (1) ATE396261T1 (fr)
AU (1) AU728614B2 (fr)
CA (1) CA2228590C (fr)
DE (1) DE69637536D1 (fr)
DK (1) DK0850304T3 (fr)
ES (1) ES2308780T3 (fr)
PT (1) PT850304E (fr)
WO (1) WO1997009425A1 (fr)

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US6121415A (en) 1997-07-09 2000-09-19 Genentech, Inc. ErbB4 receptor-specific neuregolin related ligands and uses therefor
ZA986077B (en) 1997-07-09 2000-01-10 Genentech Inc ErbB4 receptor-specific neuregulin related ligands and uses therefor.
US6994856B1 (en) 1997-07-24 2006-02-07 Genentech, Inc. ErbB4 receptor-specific neuregulin related ligands and uses therefor
US7973156B2 (en) * 1997-08-21 2011-07-05 Quark Pharmaceuticals Inc. Hypoxia-regulated genes
US20030104973A1 (en) * 1997-08-21 2003-06-05 Quark Biotech, Inc. Hypoxia-regulated genes
AUPP785098A0 (en) 1998-12-21 1999-01-21 Victor Chang Cardiac Research Institute, The Treatment of heart disease
US6635249B1 (en) 1999-04-23 2003-10-21 Cenes Pharmaceuticals, Inc. Methods for treating congestive heart failure
ES2370875T3 (es) * 2000-05-23 2011-12-23 Acorda Therapeutics, Inc. Moléculas de ácido nucleico nrg-2, polipéptidos y métodos de diagnóstico y terapéuticos.
WO2003099320A1 (fr) 2002-05-24 2003-12-04 Zensun (Shanghai) Sci-Tech.Ltd Procedes et compositions a base de neureguline pour le traitement de la myocardite virale et de la myocardiopathie dilatee
US20070213264A1 (en) 2005-12-02 2007-09-13 Mingdong Zhou Neuregulin variants and methods of screening and using thereof
US20070190127A1 (en) 2005-12-30 2007-08-16 Mingdong Zhou Extended release of neuregulin for improved cardiac function
US9580515B2 (en) 2006-08-21 2017-02-28 Zensun (Shanghai) Science & Technology, Co., Ltd. Neukinase, a downstream protein of neuregulin
US20090156488A1 (en) 2007-09-12 2009-06-18 Zensun (Shanghai) Science & Technology Limited Use of neuregulin for organ preservation
AU2009217606B2 (en) 2008-02-29 2015-03-05 Acorda Therapeutics, Inc. Method for achieving desired glial growth factor 2 plasma levels
DK3338791T3 (da) 2008-07-17 2019-12-16 Acorda Therapeutics Inc Terapeutisk dosering af en neuregulin i behandling eller profylaxis af hjertesvigt
WO2010019275A2 (fr) 2008-08-15 2010-02-18 Acorda Therapeutics, Inc. Compositions et procédés de traitement durant des périodes non aiguës consécutives à une lésion neurologique du système nerveux central
EP2808339B1 (fr) 2008-11-28 2017-02-15 Zensun (Shanghai) Science & Technology, Co., Ltd. Peptides de neuréguline et leur utilisation
EP3087998B1 (fr) 2009-06-09 2019-09-04 Zensun (Shanghai) Science & Technology, Co., Ltd. Procédés à base de neuréguline pour le traitement de l'insuffisance cardiaque
ES2748886T3 (es) 2009-06-09 2020-03-18 Zensun Shanghai Science & Tech Co Ltd Métodos basados en Neuregulina para el tratamiento de la insuficiencia cardíaca
JP6096262B2 (ja) 2009-08-25 2017-03-15 ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． ニューレグリンに基づく心不全の治療方法
CN102139095A (zh) 2010-01-29 2011-08-03 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物
WO2013053076A1 (fr) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions et procédés pour le traitement de l'insuffisance cardiaque
CA2884051A1 (fr) 2012-10-08 2014-04-17 Zensun (Shanghai) Science & Technology, Ltd. Compositions et procedes de traitement de l'insuffisance cardiaque chez les patients diabetiques
JP6542678B2 (ja) 2013-03-06 2019-07-10 アコーダ セラピューティクス インコーポレイテッド 心不全の治療または予防のためのニューレグリンまたはその断片の治療的投与の方法
EP3895724A1 (fr) 2013-05-22 2021-10-20 Zensun (Shanghai) Science and Technology, Co., Ltd. Libération prolongée de neuréguline pour le traitement de l'insuffisance cardiaque
CN110946993A (zh) 2014-01-03 2020-04-03 上海泽生科技开发股份有限公司 纽兰格林制剂的配方
WO2015140351A1 (fr) 2014-03-21 2015-09-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour renforcer la myélinisation
CN105497876B (zh) 2014-09-24 2021-01-15 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物
CN105561298A (zh) 2014-10-17 2016-05-11 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
JP7181084B2 (ja) 2015-09-25 2022-11-30 ダグラス ビー． ソーヤー， 心臓傷害を処置するための方法
AU2019252262B2 (en) 2018-04-11 2023-10-05 Salubris (Chengdu) Biotech Co., Ltd. Human neuregulin-1 (NRG-1) recombinant fusion protein compositions and methods of use thereof
CN111407881A (zh) 2019-01-07 2020-07-14 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物
US20230057622A1 (en) 2019-09-16 2023-02-23 Zensun (Shanghai) Science & Technology, Co., Ltd. Recombinant Human Neuregulin Derivatives and Use Thereof
CN113289002A (zh) 2020-02-24 2021-08-24 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延缓心力衰竭的方法和组合物
WO2022261299A1 (fr) 2021-06-10 2022-12-15 Amgen Inc. Variants de nrg-1 modifiés présentant une sélectivité améliorée vis-à-vis d'erbb4 mais pas contre erbb3
TW202400217A (zh) 2022-03-15 2024-01-01 美商信立泰生物醫藥公司 用神經調節蛋白－１融合蛋白治療纖維化及心律不整的方法

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CA2083688A1 (fr) * 1990-05-25 1991-11-26 Marc Lippman Facteur de croissance inhibiteur de la croissance de cellules surexprimant l'oncogene humain erbb-2
AU1227792A (en) * 1991-01-14 1992-08-17 Georgetown University Ligand growth factors that bind to the erbb-2 receptor protein and induce cellular responses
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IL101943A0 (en) * 1991-05-24 1992-12-30 Genentech Inc Structure,production and use of heregulin
US5367060A (en) * 1991-05-24 1994-11-22 Genentech, Inc. Structure, production and use of heregulin
US5237056A (en) * 1991-05-29 1993-08-17 President And Fellows Of Harvard College DNA encoding a protein which copurifies with acetylcholine receptor inducing activity and uses therefor
AU693767B2 (en) * 1992-08-10 1998-07-09 Cambridge Neuroscience, Inc. Inhibitors of cell proliferation, their preparation and use
GB9217316D0 (en) * 1992-08-14 1992-09-30 Ludwig Inst Cancer Res Schwann cell mitogenic factor,its preparation and use
JPH08502168A (ja) * 1992-09-29 1996-03-12 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ ニューロン細胞においてイオンチャンネル誘導活性をもつ栄養因子
AU7042994A (en) * 1993-05-21 1994-12-20 Amgen, Inc. Recombinant (neu) differentiation factors

Also Published As

Publication number Publication date
US5912326A (en) 1999-06-15
AU728614B2 (en) 2001-01-11
ES2308780T3 (es) 2008-12-01
KR19990044527A (ko) 1999-06-25
EP0850304A1 (fr) 1998-07-01
WO1997009425A1 (fr) 1997-03-13
JP2011036260A (ja) 2011-02-24
AU7156396A (en) 1997-03-27
CA2228590A1 (fr) 1997-03-13
EP0850304B1 (fr) 2008-05-21
PT850304E (pt) 2008-10-09
CA2228590C (fr) 2003-08-05
JP4642943B2 (ja) 2011-03-02
DE69637536D1 (de) 2008-07-03
JPH11512285A (ja) 1999-10-26
ATE396261T1 (de) 2008-06-15

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