DK0816340T3 - Fremgangsmåde til fremstilling af 4-[2-(2-pyridyl)-ethoxyl]benzaldehydderivater - Google Patents
Fremgangsmåde til fremstilling af 4-[2-(2-pyridyl)-ethoxyl]benzaldehydderivaterInfo
- Publication number
- DK0816340T3 DK0816340T3 DK97304554T DK97304554T DK0816340T3 DK 0816340 T3 DK0816340 T3 DK 0816340T3 DK 97304554 T DK97304554 T DK 97304554T DK 97304554 T DK97304554 T DK 97304554T DK 0816340 T3 DK0816340 T3 DK 0816340T3
- Authority
- DK
- Denmark
- Prior art keywords
- chem
- formula
- compound represented
- ethoxyl
- pyridyl
- Prior art date
Links
- RPCKLKUHBCNVQX-UHFFFAOYSA-N 4-(2-pyridin-2-ylethoxy)benzaldehyde Chemical class C1=CC(C=O)=CC=C1OCCC1=CC=CC=N1 RPCKLKUHBCNVQX-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- -1 alkaline earth metal carbonate Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 150000001467 thiazolidinediones Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16786296 | 1996-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0816340T3 true DK0816340T3 (da) | 2003-07-14 |
Family
ID=15857471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97304554T DK0816340T3 (da) | 1996-06-27 | 1997-06-26 | Fremgangsmåde til fremstilling af 4-[2-(2-pyridyl)-ethoxyl]benzaldehydderivater |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5952509A (fr) |
| EP (1) | EP0816340B1 (fr) |
| AT (1) | ATE238282T1 (fr) |
| CA (1) | CA2208878C (fr) |
| CY (1) | CY2393B1 (fr) |
| DE (1) | DE69721134T2 (fr) |
| DK (1) | DK0816340T3 (fr) |
| ES (1) | ES2191811T3 (fr) |
| PT (1) | PT816340E (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR023700A1 (es) * | 1998-11-12 | 2002-09-04 | Smithkline Beecham Plc | Un procedimiento para preparar una composicion farmaceutica que comprende un sensibilizador de insulina |
| US20030153607A1 (en) * | 1998-11-12 | 2003-08-14 | Smithkline Beecham P.L.C. | Novel composition and use |
| US20040102486A1 (en) * | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
| WO2002028857A1 (fr) * | 2000-10-05 | 2002-04-11 | Dr. Reddy's Research Foundation | Polymorphes de chlorhydrates de pioglitazone et leur utilisation en tant qu'antidiabetiques |
| FR2820742B1 (fr) * | 2001-02-14 | 2005-03-11 | Ppg Sipsy | Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine |
| US7009057B2 (en) | 2001-04-26 | 2006-03-07 | Zentiva A.S. | Method for obtaining pioglitazone as an antidiabetic agent |
| AU2002337749A1 (en) * | 2001-09-28 | 2003-04-07 | Teva Pharmaceutical Industries Ltd. | Pioglitazone hydrochloride |
| US20050187258A1 (en) * | 2001-12-20 | 2005-08-25 | Ben-Zion Dolitzky | Hydrogenation of precursors to thiazolidinedione antihyperglycemics |
| US6992191B2 (en) * | 2001-12-20 | 2006-01-31 | Teva Pharmaceutical Industries, Ltd. | Hydrogenation of precursors to thiazolidinedione antihyperglycemics |
| WO2003093262A2 (fr) * | 2002-04-29 | 2003-11-13 | Teva Pharmaceutical Industries Ltd. | Procede de preparation de losartan et de losartan potassium |
| AU2002345524A1 (en) * | 2002-06-19 | 2004-01-06 | Eos Eczacibasi Ozgun Kimyasal Urunler Sanyi Ve Ticaret A.S. | A process for the production of substituted phenyl ethers |
| US7232828B2 (en) * | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
| AU2003260813A1 (en) * | 2002-09-12 | 2004-04-30 | Themis Laboratories Private Limited | Improved process for preparation of thiazolidinedione derivatives |
| UY28457A1 (es) * | 2003-08-07 | 2005-03-31 | Sb Pharmco Inc | Nueva composición |
| GB0318824D0 (en) * | 2003-08-11 | 2003-09-10 | Glaxo Group Ltd | Novel composition |
| US20070078170A1 (en) * | 2003-08-28 | 2007-04-05 | Khanduri Chandra H | Process for the preparation of pioglitazone |
| GB0325174D0 (en) * | 2003-10-28 | 2003-12-03 | Sandoz Ag | Organic compounds |
| HUP0304096A2 (hu) * | 2003-12-19 | 2005-08-29 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás pioglitazon hidrogénklorid előállítására és intermedierjei |
| WO2005108394A1 (fr) * | 2004-05-12 | 2005-11-17 | Medichem S.A. | Procede de preparation de rosiglitazone |
| CA2611114C (fr) * | 2005-06-08 | 2014-09-23 | Orion Corporation | Forme posologique orale d'entacapone |
| US20080182880A1 (en) * | 2006-09-28 | 2008-07-31 | Mailatur Sivaraman Mohan | Pioglitazone composition |
| TW200914006A (en) * | 2007-07-12 | 2009-04-01 | Takeda Pharmaceutical | Coated preparation |
| WO2012153312A1 (fr) | 2011-05-11 | 2012-11-15 | Ranbaxy Laboratories Limited | Procédé pour la purification de pioglitazone |
| SI3125888T1 (en) | 2014-04-02 | 2018-08-31 | Minoryx Therapeutics S.L. | 2,4-TIAZOLIDINDION DERIVATIVES FOR TREATMENT OF CENTRAL STYLE SYSTEM DISEASE |
| EP3548026B1 (fr) | 2016-12-01 | 2021-01-20 | Minoryx Therapeutics S.L. | 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione pour le traitement de steatose hepatique non alcoholique |
| KR102609373B1 (ko) | 2016-12-23 | 2023-12-01 | 미노릭스 테라퓨틱스 에스.엘. | 5-[[4-[2-[5-(1-히드록시에틸)-2-피리디닐]에톡시]페닐]메틸]-2,4-티아졸리딘디온 및 이의 염의 제조 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| US4812570A (en) * | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
| ATE123278T1 (de) * | 1991-03-25 | 1995-06-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von ethern. |
| DE69231886T2 (de) * | 1991-04-11 | 2002-03-28 | Upjohn Co | Thiazolidindionderivate, herstellung und anwendung |
-
1997
- 1997-06-23 US US08/880,638 patent/US5952509A/en not_active Expired - Lifetime
- 1997-06-26 DE DE69721134T patent/DE69721134T2/de not_active Expired - Lifetime
- 1997-06-26 EP EP97304554A patent/EP0816340B1/fr not_active Expired - Lifetime
- 1997-06-26 PT PT97304554T patent/PT816340E/pt unknown
- 1997-06-26 DK DK97304554T patent/DK0816340T3/da active
- 1997-06-26 ES ES97304554T patent/ES2191811T3/es not_active Expired - Lifetime
- 1997-06-26 CA CA002208878A patent/CA2208878C/fr not_active Expired - Lifetime
- 1997-06-26 AT AT97304554T patent/ATE238282T1/de active
-
1999
- 1999-04-12 US US09/292,384 patent/US6100403A/en not_active Expired - Lifetime
-
2003
- 2003-11-28 CY CY0300088A patent/CY2393B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69721134D1 (de) | 2003-05-28 |
| EP0816340A1 (fr) | 1998-01-07 |
| ES2191811T3 (es) | 2003-09-16 |
| CY2393B1 (en) | 2004-09-10 |
| US5952509A (en) | 1999-09-14 |
| DE69721134T2 (de) | 2004-03-04 |
| CA2208878A1 (fr) | 1997-12-27 |
| US6100403A (en) | 2000-08-08 |
| ATE238282T1 (de) | 2003-05-15 |
| EP0816340B1 (fr) | 2003-04-23 |
| PT816340E (pt) | 2003-08-29 |
| CA2208878C (fr) | 2002-08-20 |
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