DK0812205T3 - Antithrombotiske azacycloalkylalkanoylpeptider og -pseudopeptider - Google Patents

Antithrombotiske azacycloalkylalkanoylpeptider og -pseudopeptider

Info

Publication number
DK0812205T3
DK0812205T3 DK95900403T DK95900403T DK0812205T3 DK 0812205 T3 DK0812205 T3 DK 0812205T3 DK 95900403 T DK95900403 T DK 95900403T DK 95900403 T DK95900403 T DK 95900403T DK 0812205 T3 DK0812205 T3 DK 0812205T3
Authority
DK
Denmark
Prior art keywords
pct
date
pseudopeptides
sec
prevention
Prior art date
Application number
DK95900403T
Other languages
Danish (da)
English (en)
Inventor
Scott I Klein
Bruce F Molino
Original Assignee
Rhone Poulenc Rorer Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Pharma filed Critical Rhone Poulenc Rorer Pharma
Application granted granted Critical
Publication of DK0812205T3 publication Critical patent/DK0812205T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06104Dipeptides with the first amino acid being acidic
    • C07K5/06113Asp- or Asn-amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK95900403T 1993-10-15 1994-10-17 Antithrombotiske azacycloalkylalkanoylpeptider og -pseudopeptider DK0812205T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13882093A 1993-10-15 1993-10-15
PCT/US1994/012135 WO1995010295A1 (en) 1993-10-15 1994-10-17 Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides

Publications (1)

Publication Number Publication Date
DK0812205T3 true DK0812205T3 (da) 2001-04-17

Family

ID=22483811

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95900403T DK0812205T3 (da) 1993-10-15 1994-10-17 Antithrombotiske azacycloalkylalkanoylpeptider og -pseudopeptider

Country Status (28)

Country Link
US (1) US5866685A (ru)
EP (1) EP0812205B1 (ru)
JP (1) JP3032297B2 (ru)
KR (1) KR100304332B1 (ru)
CN (1) CN1135717A (ru)
AT (1) ATE199727T1 (ru)
AU (1) AU703854B2 (ru)
BG (1) BG63166B1 (ru)
BR (1) BR9407839A (ru)
CA (1) CA2174097C (ru)
CZ (1) CZ291378B6 (ru)
DE (1) DE69426897T2 (ru)
DK (1) DK0812205T3 (ru)
ES (1) ES2155122T3 (ru)
FI (1) FI961634A (ru)
GR (1) GR3035581T3 (ru)
HK (1) HK1006225A1 (ru)
HU (1) HU222248B1 (ru)
NO (1) NO961460L (ru)
NZ (1) NZ275948A (ru)
PL (1) PL181749B1 (ru)
PT (1) PT812205E (ru)
RO (1) RO115520B1 (ru)
RU (1) RU2134695C1 (ru)
SG (1) SG64919A1 (ru)
SK (1) SK47796A3 (ru)
UA (1) UA44258C2 (ru)
WO (1) WO1995010295A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274705B1 (en) * 1996-05-02 2001-08-14 Aventis Pharmaceuticals Products Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
HU222248B1 (hu) * 1993-10-15 2003-05-28 Aventis Pharmaceuticals Inc. Trombózis elleni hatású (aza-cikloalkil)-alkanoil-peptidek, -pszeudopeptidek és ezeket a vegyületeket tartalmazó gyógyászati készítmények
CN1491942A (zh) * 1996-08-21 2004-04-28 ���µ�˹ҩ����Ʒ��˾ N-[n-n-(4-(哌啶-4-基)丁酰基)-n-乙基甘氨酰基]化合物的不吸湿的稳定结晶形式
IL129877A (en) * 1996-11-27 2004-08-31 Aventis Pharm Prod Inc A pharmaceutical preparation containing a component having an Xa antagonist activity and an antifouling agent
WO1999019294A1 (en) * 1997-05-14 1999-04-22 Aventis Pharmaceuticals Products Inc. Legal/Patents Process for the preparation of azacycloalkylalkanoyl pseudotetrapeptides
JP2001519411A (ja) * 1997-10-10 2001-10-23 アヴェンティス ファーマシューティカルズ プロダクツ インコーポレイテッド アザシクロアルキルアルカノイルプソイドテトラぺプチドの調製方法
EP1155033A1 (en) * 1998-12-30 2001-11-21 Aventis Pharmaceuticals Products Inc. Process for preparing a stable non-hygroscopic crystalline n-[n-[n-(piperdin-4-yl)butanoyl)-n-ethylglycyl]-(l)-aspartyl]-ss-cyclohexylalanine amide
CN101735307B (zh) * 2008-11-18 2012-05-30 北京航空航天大学 一种血小板膜糖蛋白寡肽或其修饰物/衍生物以及它们的应用
US9168233B2 (en) * 2012-06-11 2015-10-27 The Cleveland Clinic Foundation Treatment and prevention of cardiovascular disease and thrombosis

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
FR2608160B1 (fr) * 1986-12-15 1989-03-31 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
US4992463A (en) * 1988-07-20 1991-02-12 Monsanto Company Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
AU646411B2 (en) * 1989-09-29 1994-02-24 Rhone-Poulenc Rorer International (Holdings) Inc. Anti-thrombotic peptides and pseudopeptides
US5051405A (en) * 1989-10-10 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptides and pseudopeptides
US5064814A (en) * 1990-04-05 1991-11-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptide and pseudopeptide derivatives
NZ239876A (en) * 1990-09-27 1993-12-23 Merck & Co Inc Glycyl-b-alanine derivatives and pharmaceutical compositions thereof.
IL99539A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
WO1992018117A1 (en) * 1991-04-11 1992-10-29 Rhone-Poulenc Rorer International (Holdings), Inc. Anti-thrombotic peptide and pseudopeptide derivatives
HU222248B1 (hu) * 1993-10-15 2003-05-28 Aventis Pharmaceuticals Inc. Trombózis elleni hatású (aza-cikloalkil)-alkanoil-peptidek, -pszeudopeptidek és ezeket a vegyületeket tartalmazó gyógyászati készítmények

Also Published As

Publication number Publication date
HUT73856A (en) 1996-09-30
NZ275948A (en) 1997-02-24
BR9407839A (pt) 1997-05-13
AU8123794A (en) 1995-05-04
HU9600983D0 (en) 1996-06-28
CA2174097A1 (en) 1995-04-20
BG63166B1 (bg) 2001-05-31
EP0812205B1 (en) 2001-03-14
NO961460L (no) 1996-06-17
CN1135717A (zh) 1996-11-13
GR3035581T3 (en) 2001-06-29
CZ108496A3 (en) 1996-12-11
AU703854B2 (en) 1999-04-01
PT812205E (pt) 2001-08-30
CZ291378B6 (cs) 2003-02-12
EP0812205A4 (en) 1999-03-31
JP3032297B2 (ja) 2000-04-10
BG100544A (bg) 1996-11-29
SG64919A1 (en) 1999-05-25
UA44258C2 (uk) 2002-02-15
KR100304332B1 (ko) 2001-11-26
DE69426897T2 (de) 2001-07-05
JPH09507213A (ja) 1997-07-22
PL313975A1 (en) 1996-08-05
HK1006225A1 (en) 1999-02-19
PL181749B1 (pl) 2001-09-28
SK47796A3 (en) 1997-03-05
RO115520B1 (ro) 2000-03-30
CA2174097C (en) 2002-06-04
FI961634A (fi) 1996-05-23
HU222248B1 (hu) 2003-05-28
ATE199727T1 (de) 2001-03-15
FI961634A0 (fi) 1996-04-12
DE69426897D1 (de) 2001-04-19
WO1995010295A1 (en) 1995-04-20
EP0812205A1 (en) 1997-12-17
US5866685A (en) 1999-02-02
NO961460D0 (no) 1996-04-12
ES2155122T3 (es) 2001-05-01
RU2134695C1 (ru) 1999-08-20

Similar Documents

Publication Publication Date Title
RU93054168A (ru) Димер молекулярного варианта аро-липопротеина, способ его получения, фармацевтическая композиция на его основе
WO2001078709A3 (en) Treatment of neurodegenerative disease
BG103521A (en) Substituted pyrimidinon and pyridon compounds and methods for their application
EA199900778A1 (ru) ГЕТЕРОЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ И ИХ ИСПОЛЬЗОВАНИЕ ДЛЯ ИНГИБИРОВАНИЯ β-АМИЛОИДНОГО ПЕПТИДА
FR2699077B1 (fr) Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
IL113941A (en) Perfluoroalkyl ketone inhibitors of elastase processes for making the same and pharmaceutical compositions containing them
EA199900490A1 (ru) СПОСОБЫ И СОЕДИНЕНИЯ ДЛЯ ИНГИБИРОВАНИЯ ВЫДЕЛЕНИЯ β-АМИЛОИДНОГО ПЕПТИДА И/ИЛИ ЕГО СИНТЕЗА
KR960702318A (ko) 근육 질병 및 장애의 치료방법
DK0812205T3 (da) Antithrombotiske azacycloalkylalkanoylpeptider og -pseudopeptider
DE69410254T2 (de) Behandlung von mycobakteriellen erkrankungen durch verabreichung von bakrerientötende, durchlässigkeitserhöhende proteinfragmente
FI952593A (fi) Hyytymistä estävä aine
BG103512A (en) Substituted pyramidine compounds and their application
MXPA03011502A (es) Aminoalcoholes sustituidos utiles en tratamiento de enfermedad de alzheimer.
KR960000248A (ko) 골대사 질환 치료제
CA2065889A1 (en) Increasing the choroidal blood flow
ATE147978T1 (de) Verwendung von (e) - 2 - (p -fluorophenethyl)- 3 - fluoroallylamine zur behandlung der alzheimerschen krankheit
NO961357L (no) Nye terapeutisk aktive peptidforbindelser i blodkoagulasjonskaskaden, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem
MX9207343A (es) Derivados antitromboticos de acido diaminoalcanoico.
CA2060333A1 (en) Use of pyrimido-benzothiazine derivatives
RU95104302A (ru) Аппликационный материал лечебно-профилактического назначения
RU96113185A (ru) Раствор для лечения заболеваний и повреждений роговицы "кератан-с"
RU96106827A (ru) Способ профилактики образования кист поджелудочной железы