DK0789021T3 - Hydroxamsyreforbindelser som opioid kappa-receptoragonister - Google Patents
Hydroxamsyreforbindelser som opioid kappa-receptoragonisterInfo
- Publication number
- DK0789021T3 DK0789021T3 DK97200003T DK97200003T DK0789021T3 DK 0789021 T3 DK0789021 T3 DK 0789021T3 DK 97200003 T DK97200003 T DK 97200003T DK 97200003 T DK97200003 T DK 97200003T DK 0789021 T3 DK0789021 T3 DK 0789021T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- phenyl
- optionally substituted
- 4alkyl
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB9600099 | 1996-02-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0789021T3 true DK0789021T3 (da) | 2000-11-13 |
Family
ID=11004404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97200003T DK0789021T3 (da) | 1996-02-07 | 1997-01-07 | Hydroxamsyreforbindelser som opioid kappa-receptoragonister |
Country Status (10)
Country | Link |
---|---|
US (1) | US5837717A (fr) |
EP (1) | EP0789021B1 (fr) |
JP (1) | JP3190588B2 (fr) |
AT (1) | ATE196901T1 (fr) |
CA (1) | CA2196845C (fr) |
DE (1) | DE69703256T2 (fr) |
DK (1) | DK0789021T3 (fr) |
ES (1) | ES2151222T3 (fr) |
GR (1) | GR3034923T3 (fr) |
MX (1) | MX9701042A (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0982297A3 (fr) * | 1998-08-24 | 2001-08-01 | Pfizer Products Inc. | Procédé de préparation de dérivés de acide hydroxamique substitués par hydroxy-pyrrolidinyl, qui sont agonistes du récepteur opioid kappa |
US7160902B2 (en) * | 2003-11-14 | 2007-01-09 | Adolor Corporation | Amide derivatives and methods of their use |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8618188D0 (en) * | 1986-07-25 | 1986-09-03 | Ici Plc | Diamine compounds |
DE4034785A1 (de) | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | 1-(2-arylethyl)-pyrrolidine |
US5232978A (en) * | 1988-12-23 | 1993-08-03 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1-(2-arylethyl)-pyrrolidines |
JPH0730061B2 (ja) * | 1991-02-07 | 1995-04-05 | ファイザー製薬株式会社 | ヒドロキサム酸誘導体および組成物 |
US5132319A (en) * | 1991-03-28 | 1992-07-21 | Merck Frosst Canada, Inc. | 1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis |
US5128364A (en) * | 1991-03-28 | 1992-07-07 | Merck Frosst Canada, Inc. | Pyrrolo[1,2-a]indole hydroxylamine derivatives as inhibitors of leukotriene biosynthesis |
US5234933A (en) * | 1991-10-31 | 1993-08-10 | Board Of Governors Of Wayne State University And Vanderbilt University | Cyclic hydroxamic acids |
IL117440A0 (en) * | 1995-03-31 | 1996-07-23 | Pfizer | Pyrrolidinyl hydroxamic acid compounds and their production process |
-
1996
- 1996-02-07 MX MX9701042A patent/MX9701042A/es unknown
-
1997
- 1997-01-07 DE DE69703256T patent/DE69703256T2/de not_active Expired - Fee Related
- 1997-01-07 EP EP97200003A patent/EP0789021B1/fr not_active Expired - Lifetime
- 1997-01-07 ES ES97200003T patent/ES2151222T3/es not_active Expired - Lifetime
- 1997-01-07 AT AT97200003T patent/ATE196901T1/de not_active IP Right Cessation
- 1997-01-07 DK DK97200003T patent/DK0789021T3/da active
- 1997-01-28 US US08/790,246 patent/US5837717A/en not_active Expired - Fee Related
- 1997-02-05 CA CA002196845A patent/CA2196845C/fr not_active Expired - Fee Related
- 1997-02-06 JP JP03692597A patent/JP3190588B2/ja not_active Expired - Fee Related
-
2000
- 2000-11-28 GR GR20000402630T patent/GR3034923T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GR3034923T3 (en) | 2001-02-28 |
CA2196845A1 (fr) | 1997-08-08 |
DE69703256D1 (de) | 2000-11-16 |
CA2196845C (fr) | 2001-08-21 |
ATE196901T1 (de) | 2000-10-15 |
EP0789021A1 (fr) | 1997-08-13 |
ES2151222T3 (es) | 2000-12-16 |
JP3190588B2 (ja) | 2001-07-23 |
DE69703256T2 (de) | 2001-02-22 |
JPH11180950A (ja) | 1999-07-06 |
US5837717A (en) | 1998-11-17 |
EP0789021B1 (fr) | 2000-10-11 |
MX9701042A (es) | 1998-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2260703T3 (es) | Alquilaminas carentes de mitades imidazol domo ligandos del receptor h3 de histamina y sus aplicaciones terapeuticas. | |
RU94045846A (ru) | Применение производных бензотиофена для ингибирования тромбина | |
ATE279391T1 (de) | Anti-imflammtorische indolderivate | |
HU907660D0 (en) | Process for producing tricyclic compounds and pharmaceutical preparatives containing such compounds as active substances | |
ES2295609T3 (es) | Derivados de tiadiazolilpiperazina utiles para tratar o prevenir un dolor. | |
WO2002032900A3 (fr) | Composes imidazoles condenses avec aryle ou heteroaryle, utiles en tant qu'agents analgesiques anti-inflammatoires | |
ES2102132T3 (es) | Amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos. | |
GB9902455D0 (en) | Chemical compounds | |
RU2004125145A (ru) | Производные гетероциклических амидов, обладающие ингибиторной активностью в отношении гликогенфосфорилазы | |
RU94044436A (ru) | Способы подавления атрофии кожи и влагалища | |
SE9904508D0 (sv) | New compounds | |
ES2141957T3 (es) | Uso de raloxifeno y sus analogos para la produccion de un medicamento para el tratamiento de enfermedades virales. | |
EA200200119A1 (ru) | β-КАРБОЛИНОВЫЕ ЛЕКАРСТВЕННЫЕ ПРОДУКТЫ | |
RU94044454A (ru) | Ингибитор аутоимунных заболеваний | |
AU5910996A (en) | Pyrrole derivatives and medicinal composition | |
EA200500882A1 (ru) | N-арилсульфонил-3-аминоалкоксииндолы | |
CA2213815A1 (fr) | Composes d'acide pyrrolidinyl-hydroxamique et leur procede de production | |
CA2215659A1 (fr) | Composes acide morphinane-hydroxamique | |
HU9800970D0 (en) | Process for producing pharmaceutical compositions containing heptapeptide somatostatin derivatives of neurogene- and non-neurogene-antiflogistic and analgesic activity and peptidomimetica | |
RU94045156A (ru) | Применение 2-фенил-3-ароилбензотиофенов для ингибирования преждевременного полового созревания | |
EA199800155A1 (ru) | Новое соединение | |
GB9108629D0 (en) | Heterocyclic pharmaceutical compounds,preparation and use | |
DK0789021T3 (da) | Hydroxamsyreforbindelser som opioid kappa-receptoragonister | |
EA200100597A3 (ru) | Новые 1,1- и 1,2-дизамещенные циклопропановые соединения, способ их получения и содержащие их фармацевтические композиции | |
KR880005927A (ko) | 카복실산 아미드의 용도 |