DK0788347T3 - Stabile, reverse og multiple fluorcarbonhydridemulsioner - Google Patents
Stabile, reverse og multiple fluorcarbonhydridemulsionerInfo
- Publication number
- DK0788347T3 DK0788347T3 DK95923259T DK95923259T DK0788347T3 DK 0788347 T3 DK0788347 T3 DK 0788347T3 DK 95923259 T DK95923259 T DK 95923259T DK 95923259 T DK95923259 T DK 95923259T DK 0788347 T3 DK0788347 T3 DK 0788347T3
- Authority
- DK
- Denmark
- Prior art keywords
- emulsions
- reverse
- stable
- fluorocarbon
- water
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/414—Emulsifying characterised by the internal structure of the emulsion
- B01F23/4144—Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
- Fire-Extinguishing Compositions (AREA)
- Developing Agents For Electrophotography (AREA)
- Carbon And Carbon Compounds (AREA)
- Glass Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9407068A FR2720943B1 (fr) | 1994-06-09 | 1994-06-09 | Emulsions inverses stables à forte concentration en composé(s) fluoré(s) et leur utilisation pour l'administration pulmonaire de médicaments et pour la fabrication d'émulsions multiples. |
PCT/EP1995/002205 WO1995033447A1 (en) | 1994-06-09 | 1995-06-07 | Stable reverse and multiple fluorocarbon emulsions |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0788347T3 true DK0788347T3 (da) | 2000-02-28 |
Family
ID=9464044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95923259T DK0788347T3 (da) | 1994-06-09 | 1995-06-07 | Stabile, reverse og multiple fluorcarbonhydridemulsioner |
Country Status (12)
Country | Link |
---|---|
US (1) | US5904933A (da) |
EP (1) | EP0788347B1 (da) |
JP (1) | JPH10500976A (da) |
AT (1) | ATE183079T1 (da) |
AU (1) | AU706236B2 (da) |
CA (1) | CA2191436A1 (da) |
DE (1) | DE69511423T2 (da) |
DK (1) | DK0788347T3 (da) |
ES (1) | ES2137524T3 (da) |
FR (1) | FR2720943B1 (da) |
GR (1) | GR3031523T3 (da) |
WO (1) | WO1995033447A1 (da) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5770585A (en) * | 1995-05-08 | 1998-06-23 | Kaufman; Robert J. | Homogeneous water-in-perfluorochemical stable liquid dispersion for administration of a drug to the lung of an animal |
WO1996040057A2 (en) * | 1995-06-07 | 1996-12-19 | Alliance Pharmaceutical Corp. | Reverse fluorocarbon emulsion compositions for drug delivery |
US5874481A (en) * | 1995-06-07 | 1999-02-23 | Alliance Pharmaceutical Corp. | Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents |
US5667809A (en) * | 1995-06-07 | 1997-09-16 | Alliance Pharmaceutical Corp. | Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents |
FR2737135B1 (fr) * | 1995-07-24 | 1997-09-12 | Atta | Gels inverses a phase continue fluoree |
EP0935415B1 (en) * | 1996-05-01 | 2006-11-22 | Imarx Pharmaceutical Corp. | In vitro methods for delivering nucleic acids into a cell |
FR2752161B1 (fr) * | 1996-08-07 | 1998-09-25 | Atta | Emulsions multiples de type hydrocarbure-dans-eau-dans- fluorocarbone pour le transport de substances medicamenteuses hydrophiles et/ou lipophiles |
US5980936A (en) * | 1997-08-07 | 1999-11-09 | Alliance Pharmaceutical Corp. | Multiple emulsions comprising a hydrophobic continuous phase |
KR20030039363A (ko) * | 2000-07-20 | 2003-05-17 | 오뜨끄리또에 악찌오네르노에 오브셰스뜨보 나우취노-쁘로이즈보드스뜨벤나야 피르마 "뻬르프또란" | 의료용 퍼플루오르 유기화합물의 유제 및 그 제조방법 및그것을 이용한 질병 치료 및 예방방법 |
AU2002211258A1 (en) | 2000-09-26 | 2002-04-08 | North Carolina State University | Phosphate fluorosurfactants for use in carbon dioxide |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
GB0307403D0 (en) * | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
US20050221339A1 (en) * | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
HUE028691T2 (en) * | 2005-09-14 | 2016-12-28 | Mannkind Corp | A method for formulating a drug based on increasing the affinity of crystalline microparticle surfaces towards active ingredients |
US20070120088A1 (en) | 2005-10-31 | 2007-05-31 | University Of Maryland | Emulsions of heat transfer fluids including nanodroplets to enhance thermal conductivities of fluids |
US20100137163A1 (en) | 2006-01-11 | 2010-06-03 | Link Darren R | Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors |
WO2007133710A2 (en) * | 2006-05-11 | 2007-11-22 | Raindance Technologies, Inc. | Microfluidic devices and methods of use thereof |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
WO2008021123A1 (en) | 2006-08-07 | 2008-02-21 | President And Fellows Of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
EP2123256A1 (en) | 2008-05-19 | 2009-11-25 | Ruhr-Universität Bochum | Perfluorcarbon nanoemulsions with endocytosis enhancing surface for gene-transfer |
EP2315629B1 (en) | 2008-07-18 | 2021-12-15 | Bio-Rad Laboratories, Inc. | Droplet libraries |
US8524104B1 (en) * | 2008-08-28 | 2013-09-03 | Ansul, Incorporated | Fluoroalkenyl sulfate surfactants |
EP2373289A4 (en) | 2008-12-08 | 2014-07-02 | Univ Utah Res Found | STABLE PERFLUOROCARBON EMULSION FOR USE AS ARTIFICIAL OXYGEN SUPPORT |
EP2411148B1 (en) | 2009-03-23 | 2018-02-21 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
FR2948024B1 (fr) * | 2009-07-17 | 2020-01-10 | Centre National De La Recherche Scientifique - Cnrs - | Emulsion activable par ultrasons et son procede de fabrication. |
EP2486409A1 (en) | 2009-10-09 | 2012-08-15 | Universite De Strasbourg | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US8535889B2 (en) | 2010-02-12 | 2013-09-17 | Raindance Technologies, Inc. | Digital analyte analysis |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
CN102869345B (zh) | 2010-03-17 | 2015-02-11 | 诺瓦利克有限责任公司 | 用于治疗眼内压增高的药物组合物 |
EP3447155A1 (en) | 2010-09-30 | 2019-02-27 | Raindance Technologies, Inc. | Sandwich assays in droplets |
EP2444063A1 (en) | 2010-10-20 | 2012-04-25 | Novaliq GmbH | Liquid pharmaceutical compositions for the delivery of active ingredients |
EP2462921A1 (en) | 2010-11-11 | 2012-06-13 | Novaliq GmbH | Liquid pharmaceutical compositions for the treatment of a posterior eye disease |
EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
PL3192501T3 (pl) | 2011-05-25 | 2020-11-02 | Novaliq Gmbh | Kompozycja farmaceutyczna do miejscowego stosowania oparta na semifluorowanych alkanach |
EP3216872B1 (en) | 2011-06-02 | 2020-04-01 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
KR101989648B1 (ko) | 2012-01-23 | 2019-06-14 | 노바리크 게엠베하 | 부분불소화 알칸에 기초한 안정화된 단백질 조성물 |
ES2965828T3 (es) | 2012-09-12 | 2024-04-17 | Novaliq Gmbh | Composiciones de alcano semifluorado |
CA2883002C (en) | 2012-09-12 | 2019-05-21 | Novaliq Gmbh | Compositions comprising mixtures of semifluorinated alkanes |
FR2996545B1 (fr) | 2012-10-08 | 2016-03-25 | Ecole Polytech | Procede microfluidique de traitement et d'analyse d'une solution contenant un materiel biologique, et circuit microfluidique correspondant. |
US10273298B2 (en) | 2013-07-23 | 2019-04-30 | Novaliq Gmbh | Stabilized antibody compositions |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
WO2015103367A1 (en) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | System and method for detection of rna species |
EP3708256B1 (en) | 2015-04-22 | 2022-11-30 | Stilla Technologies | Contact-less priming method for loading a solution in a microfluidic device and associated system |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
EP3722274B1 (en) | 2015-09-30 | 2023-06-07 | Novaliq GmbH | 2-perfluorobutyl pentane for ophthalmic administration |
CN110403923B (zh) | 2015-09-30 | 2021-09-21 | 诺瓦利克有限责任公司 | 半氟化化合物和其组合物 |
DK3442480T3 (da) | 2016-06-23 | 2020-01-13 | Novaliq Gmbh | Fremgangsmåde til topisk indgivelse |
EP3491093A4 (en) * | 2016-07-28 | 2020-04-15 | Honeywell International Inc. | PROPELLANTS AND EMULSIFICATION COMPOSITIONS |
ES2969758T3 (es) | 2016-09-22 | 2024-05-22 | Novaliq Gmbh | Composiciones farmacéuticas para usar en la terapia de la blefaritis |
CN109906085B (zh) | 2016-09-23 | 2024-03-08 | 诺瓦利克有限责任公司 | 含有环孢素的眼用组合物 |
AU2018253944B2 (en) | 2017-04-21 | 2022-09-15 | Dermaliq Therapeutics, Inc. | Iodine compositions |
EP3621601A1 (en) | 2017-05-12 | 2020-03-18 | Novaliq GmbH | Pharmaceutical compositions comprosing semifluorinated alkanes for the treatment of contact lense-related conditions |
US11723861B2 (en) | 2017-09-27 | 2023-08-15 | Novaliq Gmbh | Ophthalmic compositions comprising latanoprost for use in the treatment of ocular diseases |
US11896559B2 (en) | 2017-10-04 | 2024-02-13 | Novaliq Gmbh | Opthalmic compositions comprising F6H8 |
SG11202007858VA (en) | 2018-03-02 | 2020-09-29 | Novaliq Gmbh | Pharmaceutical compositions comprising nebivolol |
WO2020064556A1 (en) | 2018-09-27 | 2020-04-02 | Novaliq Gmbh | Topical sunscreen formulation |
SG11202102820VA (en) | 2018-10-12 | 2021-04-29 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3975512A (en) * | 1970-12-21 | 1976-08-17 | University Of Illinois Foundation | Non-toxic brominated perfluorocarbons radiopaque agents |
FR2515198A1 (fr) * | 1981-10-22 | 1983-04-29 | Centre Nat Rech Scient | Microemulsions aqueuses de fluorocarbures indefiniment stables a une temperature donnee, procede d'obtention et application a titre de transporteurs d'oxygene |
JPS57109714A (en) * | 1980-12-27 | 1982-07-08 | Taihoo Kogyo Kk | Magnetic fluid containing carcinostatic agent |
US4917930A (en) * | 1984-04-16 | 1990-04-17 | Adamantech, Inc. | Perfluoro compound dispersions containing reduced amounts of surfactant and process of preparation |
IT1183530B (it) * | 1985-03-29 | 1987-10-22 | Monteluos S P A | Composizioni per cosmesi comprendente perfluoropolieteri |
US4987154A (en) * | 1986-01-14 | 1991-01-22 | Alliance Pharmaceutical Corp. | Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use |
IL82308A (en) * | 1986-06-26 | 1990-11-29 | Ausimont Spa | Microemulsions containing perfluoropolyethers |
FR2602774B1 (fr) * | 1986-07-29 | 1990-10-19 | Atta | Nouvelles molecules amphiphiles polyhydroxylees et perfluoroalkylees ayant des proprietes tensioactives |
FR2620445B1 (fr) * | 1987-09-16 | 1990-07-20 | Centre Nat Rech Scient | Nouveaux derives fluores d'acides amines, utilisables en particulier comme agents tensioactifs ou cotensioactifs et preparations a usage biomedical comprenant ces derives |
US4975468A (en) * | 1989-04-03 | 1990-12-04 | Affinity Biotech, Inc. | Fluorinated microemulsion as oxygen carrier |
WO1990015807A1 (en) * | 1989-06-22 | 1990-12-27 | Applications Et Transferts De Technologies Avancées | Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties |
JPH07501259A (ja) * | 1990-06-01 | 1995-02-09 | リサーチ コーポレイション テクノロジーズ,インコーポレイテッド | 自己乳化型ガラス |
FR2665705B1 (fr) * | 1990-08-09 | 1993-07-30 | Atta | Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical. |
DE4100059C2 (de) * | 1991-01-03 | 1994-08-25 | Adatomed Pharma & Med | Behandlungsflüssigkeit zum Wiederanlegen (Entfalten) abgelöster Netzhaut an die Aderhaut des Auges |
FR2679150A1 (fr) * | 1991-07-17 | 1993-01-22 | Atta | Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations. |
FR2694559B1 (fr) * | 1992-08-06 | 1994-10-28 | Atta | Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical. |
-
1994
- 1994-06-09 FR FR9407068A patent/FR2720943B1/fr not_active Expired - Fee Related
-
1995
- 1995-06-07 AU AU27887/95A patent/AU706236B2/en not_active Ceased
- 1995-06-07 CA CA002191436A patent/CA2191436A1/en not_active Abandoned
- 1995-06-07 DK DK95923259T patent/DK0788347T3/da active
- 1995-06-07 WO PCT/EP1995/002205 patent/WO1995033447A1/en active IP Right Grant
- 1995-06-07 JP JP8500370A patent/JPH10500976A/ja active Pending
- 1995-06-07 AT AT95923259T patent/ATE183079T1/de not_active IP Right Cessation
- 1995-06-07 DE DE69511423T patent/DE69511423T2/de not_active Expired - Fee Related
- 1995-06-07 US US08/478,824 patent/US5904933A/en not_active Expired - Fee Related
- 1995-06-07 EP EP95923259A patent/EP0788347B1/en not_active Expired - Lifetime
- 1995-06-07 ES ES95923259T patent/ES2137524T3/es not_active Expired - Lifetime
-
1999
- 1999-10-13 GR GR990402619T patent/GR3031523T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FR2720943B1 (fr) | 1996-08-23 |
CA2191436A1 (en) | 1995-12-14 |
DE69511423T2 (de) | 2000-01-05 |
EP0788347A1 (en) | 1997-08-13 |
ES2137524T3 (es) | 1999-12-16 |
AU706236B2 (en) | 1999-06-10 |
WO1995033447A1 (en) | 1995-12-14 |
ATE183079T1 (de) | 1999-08-15 |
GR3031523T3 (en) | 2000-01-31 |
AU2788795A (en) | 1996-01-04 |
US5904933A (en) | 1999-05-18 |
JPH10500976A (ja) | 1998-01-27 |
EP0788347B1 (en) | 1999-08-11 |
FR2720943A1 (fr) | 1995-12-15 |
DE69511423D1 (de) | 1999-09-16 |
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