DK0743312T3 - Spiroheterocykliske forbindelser, fremgangsmåde til fremstilling heraf og pharmaceutiske sammensætninger indeholdende disse - Google Patents
Spiroheterocykliske forbindelser, fremgangsmåde til fremstilling heraf og pharmaceutiske sammensætninger indeholdende disseInfo
- Publication number
- DK0743312T3 DK0743312T3 DK96401029T DK96401029T DK0743312T3 DK 0743312 T3 DK0743312 T3 DK 0743312T3 DK 96401029 T DK96401029 T DK 96401029T DK 96401029 T DK96401029 T DK 96401029T DK 0743312 T3 DK0743312 T3 DK 0743312T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- substd
- opt
- alkoxy
- halo
- Prior art date
Links
- -1 Spiro heterocyclic compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9505833A FR2734265B1 (fr) | 1995-05-17 | 1995-05-17 | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0743312T3 true DK0743312T3 (da) | 2000-05-22 |
Family
ID=9479065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96401029T DK0743312T3 (da) | 1995-05-17 | 1996-05-13 | Spiroheterocykliske forbindelser, fremgangsmåde til fremstilling heraf og pharmaceutiske sammensætninger indeholdende disse |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5698567A (de) |
| EP (1) | EP0743312B1 (de) |
| JP (1) | JPH08311067A (de) |
| CN (1) | CN1058014C (de) |
| AT (1) | ATE186729T1 (de) |
| AU (1) | AU702587B2 (de) |
| CA (1) | CA2176668C (de) |
| DE (1) | DE69605145T2 (de) |
| DK (1) | DK0743312T3 (de) |
| ES (1) | ES2142030T3 (de) |
| FR (1) | FR2734265B1 (de) |
| GR (1) | GR3032171T3 (de) |
| NO (1) | NO307756B1 (de) |
| NZ (1) | NZ286604A (de) |
| ZA (1) | ZA963950B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
| US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| AU2003236366A1 (en) * | 2002-04-05 | 2003-10-20 | Sankyo Company, Limited | Oxazolidinone derivatives |
| US7205006B2 (en) * | 2003-09-25 | 2007-04-17 | Prime Pharmaceutical Corporation | Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same |
| JPWO2005047286A1 (ja) * | 2003-11-13 | 2007-05-31 | 小野薬品工業株式会社 | スピロ複素環化合物 |
| NZ551603A (en) | 2004-06-24 | 2010-11-26 | Incyte Corp | N-substituted piperidines and their use as pharmaceuticals |
| JP2008504280A (ja) | 2004-06-24 | 2008-02-14 | インサイト・コーポレイション | ２−メチルプロパンアミドおよびその医薬としての使用 |
| KR20070024639A (ko) * | 2004-06-24 | 2007-03-02 | 인사이트 산 디에고 인코포레이티드 | 아미도 화합물 및 약제로서의 이의 용도 |
| CA2585797C (en) * | 2004-11-10 | 2015-01-06 | Incyte Corporation | Lactam compounds and their use as pharmaceuticals |
| US8110581B2 (en) | 2004-11-10 | 2012-02-07 | Incyte Corporation | Lactam compounds and their use as pharmaceuticals |
| US8193208B2 (en) * | 2005-09-09 | 2012-06-05 | Purdue Pharma L.P. | Fused and spirocycle compounds and the use thereof |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
| GB201416346D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
| GB201416351D0 (en) | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Heterocyclic derivatives |
| GB201416352D0 (en) | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
| ES2797904T3 (es) | 2016-01-13 | 2020-12-04 | Gruenenthal Gmbh | Derivados de 3-((hetero)aril)alquil-8-amino-2-oxo-1,3-diazaespiro-[4.5]-decano |
| AR107358A1 (es) | 2016-01-13 | 2018-04-25 | Gruenenthal Gmbh | Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
| DK3402783T3 (da) | 2016-01-13 | 2020-05-04 | Gruenenthal Gmbh | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decan-derivater |
| RS60855B1 (sr) | 2016-01-13 | 2020-10-30 | Gruenenthal Gmbh | Derivati 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana |
| RS60307B1 (sr) | 2016-01-13 | 2020-07-31 | Gruenenthal Gmbh | Derivati 3-((hetero-)aril)-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana |
| US11976052B2 (en) | 2019-01-11 | 2024-05-07 | Naegis Pharmaceuticals Inc. | Leukotriene synthesis inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL127065C (de) * | 1964-04-22 | |||
| FR2666583B1 (fr) * | 1990-09-06 | 1994-09-09 | Adir | Nouveaux derives du spiro [4.5] decane, leur procede de preparation et leurs compositions pharmaceutiques les renfermant. |
| AU6126596A (en) * | 1995-06-23 | 1997-01-22 | F. Hoffmann-La Roche Ag | 1,3,8-triaza- and 3,8-diaza-1-oxaspiro(4,5)decane derivatives |
-
1995
- 1995-05-17 FR FR9505833A patent/FR2734265B1/fr not_active Expired - Lifetime
-
1996
- 1996-05-13 DK DK96401029T patent/DK0743312T3/da active
- 1996-05-13 EP EP96401029A patent/EP0743312B1/de not_active Expired - Lifetime
- 1996-05-13 AT AT96401029T patent/ATE186729T1/de not_active IP Right Cessation
- 1996-05-13 DE DE69605145T patent/DE69605145T2/de not_active Expired - Fee Related
- 1996-05-13 ES ES96401029T patent/ES2142030T3/es not_active Expired - Lifetime
- 1996-05-15 JP JP8120277A patent/JPH08311067A/ja active Pending
- 1996-05-15 CA CA002176668A patent/CA2176668C/fr not_active Expired - Fee Related
- 1996-05-15 AU AU52293/96A patent/AU702587B2/en not_active Ceased
- 1996-05-16 NZ NZ286604A patent/NZ286604A/en unknown
- 1996-05-16 US US08/649,020 patent/US5698567A/en not_active Expired - Fee Related
- 1996-05-17 ZA ZA963950A patent/ZA963950B/xx unknown
- 1996-05-17 CN CN96100292A patent/CN1058014C/zh not_active Expired - Fee Related
- 1996-05-20 NO NO962043A patent/NO307756B1/no not_active IP Right Cessation
-
1999
- 1999-12-17 GR GR990403257T patent/GR3032171T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO962043D0 (no) | 1996-05-20 |
| AU5229396A (en) | 1996-11-28 |
| JPH08311067A (ja) | 1996-11-26 |
| ZA963950B (en) | 1996-11-25 |
| NO962043L (no) | 1996-11-18 |
| EP0743312A1 (de) | 1996-11-20 |
| CN1136568A (zh) | 1996-11-27 |
| CN1058014C (zh) | 2000-11-01 |
| NZ286604A (en) | 1998-01-26 |
| EP0743312B1 (de) | 1999-11-17 |
| GR3032171T3 (en) | 2000-04-27 |
| AU702587B2 (en) | 1999-02-25 |
| FR2734265A1 (fr) | 1996-11-22 |
| CA2176668A1 (fr) | 1996-11-18 |
| DE69605145D1 (de) | 1999-12-23 |
| CA2176668C (fr) | 2001-11-20 |
| DE69605145T2 (de) | 2000-08-17 |
| US5698567A (en) | 1997-12-16 |
| ES2142030T3 (es) | 2000-04-01 |
| ATE186729T1 (de) | 1999-12-15 |
| NO307756B1 (no) | 2000-05-22 |
| FR2734265B1 (fr) | 1997-06-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0743312T3 (da) | Spiroheterocykliske forbindelser, fremgangsmåde til fremstilling heraf og pharmaceutiske sammensætninger indeholdende disse | |
| AU1328088A (en) | Herbicidal compounds | |
| HUT58299A (en) | Process for producing 2-/2-/pyrimidyl-oxy/or thio/-phenyl/-3-methoxy-propenecarboxylic acid-methyl-ester derivatives and fungicide compositions containing them as active components | |
| IL107426A0 (en) | Heterocyclic compounds, processes for the preparation thereof, and pharmaceutical compositions containing the same | |
| ZA909901B (en) | Peptide compounds,a process for preparation thereof and pharmaceutical composition comprising the same | |
| DE68915225D1 (de) | Benzazol-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten. | |
| IL104573A0 (en) | Azaindoles,their preparation and pharmaceutical compositions containing them | |
| IL101785A0 (en) | Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same | |
| EP0131684A3 (en) | Triazolylethanol derivatives and their compositions as non-agricultural fungicides | |
| DE69130683T2 (de) | PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL | |
| NZ229933A (en) | Heterocyclically substituted alpha arylacrylates and plant fungicidal compositions | |
| ATE141092T1 (de) | Methyl 2-(2-(3-substituierte phenoxy)pyridin-3- yl>-3-methoxypropenoate und ihre verwendung als pilztötendes mittel | |
| HUT66515A (en) | Process for preparing piperidine derivatives and pharmaceutical compositions contg. them as active ingredients | |
| ZA937308B (en) | Ellipticine compounds a process for their preparation and pharmaceutical compositions containing them | |
| HU906388D0 (en) | Herbicide preparatives containing puyridine derivatives | |
| IL101033A0 (en) | 5-(substituted amino)-1,2,4-triazolo(1,5-a)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them | |
| DK434789D0 (da) | 3-piperidinyl-indazolderivater, fremgangsmaade til fremstilling deraf samt praeparater indeholdende samme | |
| GR3033991T3 (en) | Thiophene compounds, a method for their preparation and pharmaceutical compositions containing them | |
| NZ336876A (en) | Process for preparation of 4-H-4-oxo-quinolizine-3-carboxylic acid derivatives | |
| HUT53487A (en) | Fungicide compositions containing nitrogen-containing heterocyclic compounds as active components and process for producing the active components | |
| GR3023923T3 (en) | 1-alpha-cyclopropyl-alpha-(substituted oxy)-o-tolyl sulfamoyl -3-(4,6-dimethoxy-2-pyrimidinyl)urea herbicidal agents. |