DK0703904T3 - Pyrimidin-cyanoguanidiner som K-kanalblokkere - Google Patents

Pyrimidin-cyanoguanidiner som K-kanalblokkere

Info

Publication number
DK0703904T3
DK0703904T3 DK94904387T DK94904387T DK0703904T3 DK 0703904 T3 DK0703904 T3 DK 0703904T3 DK 94904387 T DK94904387 T DK 94904387T DK 94904387 T DK94904387 T DK 94904387T DK 0703904 T3 DK0703904 T3 DK 0703904T3
Authority
DK
Denmark
Prior art keywords
alkyl
hydrogen
pyrimidine
channel blockers
formula
Prior art date
Application number
DK94904387T
Other languages
Danish (da)
English (en)
Inventor
Jackson B Hester Jr
Stephen J Humphrey
James R Ludens
Kaushik D Meisheri
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1993/005458 external-priority patent/WO1994004499A1/fr
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK0703904T3 publication Critical patent/DK0703904T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK94904387T 1993-06-11 1993-11-26 Pyrimidin-cyanoguanidiner som K-kanalblokkere DK0703904T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1993/005458 WO1994004499A1 (fr) 1992-08-13 1993-06-11 Des cyanoguanidines, agents bloquants du canal potassium
PCT/US1993/011332 WO1994029280A1 (fr) 1993-06-11 1993-11-26 Cyanoguanidines au pyrimidine utilisees en tant qu'agents bloquant des vannes a potassium

Publications (1)

Publication Number Publication Date
DK0703904T3 true DK0703904T3 (da) 1999-09-27

Family

ID=22236674

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94904387T DK0703904T3 (da) 1993-06-11 1993-11-26 Pyrimidin-cyanoguanidiner som K-kanalblokkere

Country Status (11)

Country Link
EP (1) EP0703904B1 (fr)
JP (1) JPH08511264A (fr)
AT (1) ATE176905T1 (fr)
AU (1) AU673785B2 (fr)
CA (1) CA2161325A1 (fr)
DE (1) DE69323633T2 (fr)
DK (1) DK0703904T3 (fr)
ES (1) ES2127918T3 (fr)
GR (1) GR3029737T3 (fr)
NZ (1) NZ259600A (fr)
WO (1) WO1994029280A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1917244A2 (fr) 2005-08-24 2008-05-07 Abbott GmbH & Co. KG Composes guanidine a substitution hetaryl et utilisation en tant que partenaires de liaison pour des recepteurs de 5-ht5

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1489879A (en) * 1974-12-20 1977-10-26 Leo Pharm Prod Ltd N'-cyano-n'-3-pyridylguanidines
NL8000869A (nl) * 1979-02-16 1980-08-19 Eisai Co Ltd Cyanoguanidine-derivaten en werkwijze voor de bereiding daarvan.
NZ229828A (en) * 1988-08-09 1992-03-26 Squibb & Sons Inc Aryl cyanoguanidine derivatives and pharmaceutical compositions
CA2009074C (fr) * 1989-02-03 1999-07-27 David Wayne Robertson Ameliorations concernant les derives de guanidine
US5006523A (en) * 1989-10-26 1991-04-09 E. R. Squibb & Sons, Inc. Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers

Also Published As

Publication number Publication date
JPH08511264A (ja) 1996-11-26
AU673785B2 (en) 1996-11-21
ATE176905T1 (de) 1999-03-15
EP0703904A1 (fr) 1996-04-03
ES2127918T3 (es) 1999-05-01
GR3029737T3 (en) 1999-06-30
DE69323633T2 (de) 1999-07-08
NZ259600A (en) 1997-08-22
WO1994029280A1 (fr) 1994-12-22
EP0703904B1 (fr) 1999-02-24
DE69323633D1 (de) 1999-04-01
CA2161325A1 (fr) 1994-12-22
AU1030395A (en) 1995-01-03

Similar Documents

Publication Publication Date Title
DK1585739T3 (da) Substituerede arylcyclopropylacetamider som glucokinaseaktivatorer
UY26512A1 (es) Inhibidores no peptídicos de la unión celúlar dependiente de vla - 4 útiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias
CY1107228T1 (el) Αποκλειστες διαυλων νατριου
NO883487D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser.
AR005672A1 (es) Derivados de la distamicina, proceso para prepararlos, y su utilizacion como agentes antitumorales y antivirales.
NO20050871L (no) 6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer
RS50229B (sr) Analozi vitamina d3
DK0655057T3 (da) Cyanoguanidiner som kaliumkanalblokkere
NO944069L (no) Hemming av uterinfibrose
EP1331224A4 (fr) Derivates thiazole ou oxazole
MY130375A (en) Non-nucleoside reverse trancriptase inhibitors
DE69408580D1 (de) 2-amino-1,2,3,4-tetrahydronaphthalenderivate mit cardiovaskulärer wirkung
DK0703904T3 (da) Pyrimidin-cyanoguanidiner som K-kanalblokkere
CA2209422A1 (fr) Derives 4-amino-3-acylnaphtyridine
NO20023041L (no) Fremgangsmåte for fremstilling av pyrazolopyridazinderivater
UA43338C2 (uk) Похідні бензолу
MY131544A (en) Fluorinated 4-aminoandrostadienone derivatives and process for their preparation
DK0705263T3 (da) Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner
MX9603051A (es) Cianoguanidinas como bloqueadores del canal-k.
DK1049672T3 (da) Azetidincarboxamid-derivater til behandling af CNS-lidelser
TH14335EX (th) ไซแอโนกัวนิดีนเป็นตัวสกัดกั้นช่องผ่านออกของโพแทสเซียม
FI935690A0 (fi) Oralt aktiva antivirala foereningar
SE7713864L (sv) Nortropinkarbazatderivat och forfarande for framstellning av dem
CO4810228A1 (es) Derivados de pirazol piridazina, procesos para su preparacion y composiciones farmaceuticas que los contienen