DK0691986T3 - Hidtil ukendte fremgangsmåder og mellemproduktforbindelser til fremstillingen af blodpladeglycoprotein IIb/IIIa-inhibitorer - Google Patents
Hidtil ukendte fremgangsmåder og mellemproduktforbindelser til fremstillingen af blodpladeglycoprotein IIb/IIIa-inhibitorerInfo
- Publication number
- DK0691986T3 DK0691986T3 DK94911702T DK94911702T DK0691986T3 DK 0691986 T3 DK0691986 T3 DK 0691986T3 DK 94911702 T DK94911702 T DK 94911702T DK 94911702 T DK94911702 T DK 94911702T DK 0691986 T3 DK0691986 T3 DK 0691986T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- intermediate compounds
- glycoprotein iib
- platelet glycoprotein
- novel methods
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229940127392 Platelet Glycoprotein IIb/IIIA Inhibitors Drugs 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3843493A | 1993-03-29 | 1993-03-29 | |
| PCT/US1994/003221 WO1994022909A1 (en) | 1993-03-29 | 1994-03-28 | NOVEL PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PLATELET CLYCOPROTEIN IIb/IIIa INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0691986T3 true DK0691986T3 (da) | 1999-08-16 |
Family
ID=21899933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94911702T DK0691986T3 (da) | 1993-03-29 | 1994-03-28 | Hidtil ukendte fremgangsmåder og mellemproduktforbindelser til fremstillingen af blodpladeglycoprotein IIb/IIIa-inhibitorer |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5817749A (ja) |
| EP (1) | EP0691986B1 (ja) |
| JP (1) | JPH08509708A (ja) |
| AT (1) | ATE174036T1 (ja) |
| AU (1) | AU682857B2 (ja) |
| CA (1) | CA2159072A1 (ja) |
| DE (1) | DE69415001T2 (ja) |
| DK (1) | DK0691986T3 (ja) |
| ES (1) | ES2126748T3 (ja) |
| GR (1) | GR3029453T3 (ja) |
| NZ (1) | NZ263455A (ja) |
| WO (1) | WO1994022909A1 (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA978758B (en) * | 1996-10-02 | 1999-03-30 | Du Pont Merck Pharma | Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3505555A1 (de) * | 1985-02-18 | 1986-09-11 | Behringwerke Ag, 3550 Marburg | Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel |
| FR2636066B1 (fr) * | 1988-09-02 | 1991-10-25 | Centre Nat Rech Scient | Derives de cyclopeptides, utilisables comme inhibiteurs selectifs vis-a-vis de proteases a serine active |
| JP2945680B2 (ja) * | 1988-09-09 | 1999-09-06 | 旭硝子株式会社 | ペプチド誘導体およびその用途 |
| DD289543A5 (de) * | 1989-05-12 | 1991-05-02 | Univ Halle Wittenberg | Neue pharmakologisch-aktive cyclopeptide und verfahren zu ihrer herstellung |
| US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
| NZ235564A (en) * | 1989-10-13 | 1993-10-26 | Merck & Co Inc | Fibrinogen receptor antagonist and pharmaceutical compositions |
| AU6470590A (en) * | 1989-10-23 | 1991-04-26 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
| CA2036973A1 (en) * | 1990-02-27 | 1991-08-28 | Mark G. Bock | Cyclic hexapeptide oxytocin antagonists |
| US5192746A (en) * | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
| EP0540626A1 (en) * | 1990-07-24 | 1993-05-12 | Eastman Chemical Company | Process for synthesizing peptides |
| CA2092315A1 (en) * | 1990-11-02 | 1992-05-03 | John P. Burnier | Platelet aggregation inhibitors |
| IL103252A (en) * | 1991-09-30 | 1997-03-18 | Du Pont Merck Pharma | CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| SG52262A1 (en) * | 1993-01-08 | 1998-09-28 | Tanabe Seiyaku Co | Peptide inhibitors of cell adhesion |
| WO1994022911A2 (en) * | 1993-03-29 | 1994-10-13 | The Du Pont Merck Pharmaceutical Company | A PROCESS AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS CONTAINING Nα-METHYLARGININE |
| CA2159070A1 (en) * | 1993-03-29 | 1994-10-13 | William Frank Degrado | Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia |
-
1994
- 1994-03-28 ES ES94911702T patent/ES2126748T3/es not_active Expired - Lifetime
- 1994-03-28 AT AT94911702T patent/ATE174036T1/de not_active IP Right Cessation
- 1994-03-28 DE DE69415001T patent/DE69415001T2/de not_active Expired - Fee Related
- 1994-03-28 WO PCT/US1994/003221 patent/WO1994022909A1/en active IP Right Grant
- 1994-03-28 JP JP6522193A patent/JPH08509708A/ja active Pending
- 1994-03-28 EP EP94911702A patent/EP0691986B1/en not_active Expired - Lifetime
- 1994-03-28 AU AU64157/94A patent/AU682857B2/en not_active Ceased
- 1994-03-28 CA CA002159072A patent/CA2159072A1/en not_active Abandoned
- 1994-03-28 NZ NZ263455A patent/NZ263455A/en unknown
- 1994-03-28 DK DK94911702T patent/DK0691986T3/da active
-
1995
- 1995-01-12 US US08/371,624 patent/US5817749A/en not_active Expired - Fee Related
-
1999
- 1999-02-19 GR GR990400538T patent/GR3029453T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994022909A1 (en) | 1994-10-13 |
| JPH08509708A (ja) | 1996-10-15 |
| US5817749A (en) | 1998-10-06 |
| AU682857B2 (en) | 1997-10-23 |
| DE69415001T2 (de) | 1999-05-06 |
| AU6415794A (en) | 1994-10-24 |
| DE69415001D1 (de) | 1999-01-14 |
| CA2159072A1 (en) | 1994-10-13 |
| GR3029453T3 (en) | 1999-05-28 |
| ATE174036T1 (de) | 1998-12-15 |
| ES2126748T3 (es) | 1999-04-01 |
| EP0691986A1 (en) | 1996-01-17 |
| NZ263455A (en) | 1997-10-24 |
| EP0691986B1 (en) | 1998-12-02 |
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