DK0674516T3 - Antiproliferative substituerede 5-thiapyrimidinon- og 5-selenopyrimidinonforbindelser - Google Patents

Antiproliferative substituerede 5-thiapyrimidinon- og 5-selenopyrimidinonforbindelser

Info

Publication number
DK0674516T3
DK0674516T3 DK94904399T DK94904399T DK0674516T3 DK 0674516 T3 DK0674516 T3 DK 0674516T3 DK 94904399 T DK94904399 T DK 94904399T DK 94904399 T DK94904399 T DK 94904399T DK 0674516 T3 DK0674516 T3 DK 0674516T3
Authority
DK
Denmark
Prior art keywords
compounds
selenopyrimidinone
thiapyrimidinone
disclosed
antiproliferative
Prior art date
Application number
DK94904399T
Other languages
English (en)
Inventor
Judith G Deal
Michael D Varney
William H Romines
Cynthia L Palmer
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Application granted granted Critical
Publication of DK0674516T3 publication Critical patent/DK0674516T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK94904399T 1992-12-16 1993-12-10 Antiproliferative substituerede 5-thiapyrimidinon- og 5-selenopyrimidinonforbindelser DK0674516T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99125992A 1992-12-16 1992-12-16
PCT/US1993/011795 WO1994013295A1 (en) 1992-12-16 1993-12-10 Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds

Publications (1)

Publication Number Publication Date
DK0674516T3 true DK0674516T3 (da) 2000-07-24

Family

ID=25537030

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94904399T DK0674516T3 (da) 1992-12-16 1993-12-10 Antiproliferative substituerede 5-thiapyrimidinon- og 5-selenopyrimidinonforbindelser

Country Status (13)

Country Link
US (5) US5739141A (da)
EP (1) EP0674516B1 (da)
JP (1) JPH08504765A (da)
AT (1) ATE189390T1 (da)
AU (1) AU5846494A (da)
CA (1) CA2151588C (da)
DE (1) DE69327796T2 (da)
DK (1) DK0674516T3 (da)
ES (1) ES2145122T3 (da)
GR (1) GR3033314T3 (da)
PT (1) PT674516E (da)
SG (1) SG52739A1 (da)
WO (1) WO1994013295A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945427A (en) * 1995-06-07 1999-08-31 Agouron Pharmaceuticals, Inc. Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
WO1994013295A1 (en) 1992-12-16 1994-06-23 Agouron Pharmaceuticals, Inc. Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
US5594139A (en) * 1993-01-29 1997-01-14 Agouron Pharmaceuticals, Inc. Processes for preparing antiproliferative garft-inhibiting compounds
CN1053448C (zh) * 1994-07-28 2000-06-14 阿格罗尼制药公司 用作抗增殖药物及garft抑制剂的化合物
US5608082A (en) * 1994-07-28 1997-03-04 Agouron Pharmaceuticals, Inc. Compounds useful as antiproliferative agents and GARFT inhibitors
ATE242253T1 (de) * 1994-07-28 2003-06-15 Agouron Pharma Verbindungen die als antiproliferierende mittel und garft inhibitoren verwendbar sind
US5831100A (en) * 1995-06-07 1998-11-03 Agouron Pharmaceuticals, Inc. Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
AUPO227896A0 (en) * 1996-09-13 1996-10-03 Fujisawa Pharmaceutical Co., Ltd. Novel compounds and their preparation
ATE353640T1 (de) * 1998-03-27 2007-03-15 Genentech Inc Antagoniste zur behandlung von cd11/cd18 adhäsionsrezeptor-vermittelten krankheiten
PT1109560E (pt) 1998-09-04 2004-01-30 Agouron Pharma Compostos uteis como inidores de aicarft
US6423720B1 (en) * 2001-02-01 2002-07-23 Duquesne University Of The Holy Ghost Pyrimidine compounds and methods for making and using the same
US20040043959A1 (en) * 2002-03-04 2004-03-04 Bloom Laura A. Combination therapies for treating methylthioadenosine phosphorylase deficient cells
EP2295976A1 (en) 2003-03-08 2011-03-16 Auvation Ltd Markers for colorectal cancer
SG194352A1 (en) 2005-03-28 2013-11-29 Pericor Therapeutics Inc Methods, compositions, and formulations for preventing or reducing adverse effects in a patient
US20070082859A1 (en) * 2005-10-07 2007-04-12 Stover Richard R Formulations of AICA riboside
WO2008086341A1 (en) * 2007-01-09 2008-07-17 Pericor Therapeutics, Inc. Methods. compositions, and formulations for preventing or reducing adverse effects in a patient
US8063033B2 (en) 2008-01-18 2011-11-22 Allergan, Inc. Therapeutic beta-lactams
US7956051B2 (en) 2008-01-24 2011-06-07 Allergan, Inc. Therapeutic amides and related compounds
US7705001B2 (en) 2008-03-18 2010-04-27 Allergan, Inc Therapeutic substituted gamma lactams
RU2010149492A (ru) 2008-05-09 2012-06-20 Аллерган, Инк. (Us) Терапевтические производные n-арил- или n-гетероарилпиразолидина и пиразолидинона
US7985765B2 (en) 2008-08-20 2011-07-26 Allergan, Inc. Therapeutic substituted pyrroles
CA2739463C (en) * 2008-10-03 2018-07-03 Pericor Therapeutics, Inc. Methods and compositions for treatment of acute heart failure
US9090584B2 (en) 2010-01-26 2015-07-28 Allergan, Inc. Therapeutic agents for treatment of ocular hypertension
EP3227279B1 (en) * 2014-12-02 2019-02-13 Eli Lilly and Company 1-oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as aicarft inhibitors in the treatment of cancers
DE102017221259A1 (de) * 2017-11-28 2019-05-29 Evonik Degussa Gmbh Silanmischungen und Verfahren zu deren Herstellung
CN112321425B (zh) * 2020-10-23 2022-08-09 上海毕得医药科技股份有限公司 一种4-(3-溴丙基)苯甲酸甲酯的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3222914A1 (de) * 1982-06-18 1983-12-22 Beiersdorf Ag, 2000 Hamburg Substituierte 5-phenylthio-6-amino-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
GB8625019D0 (en) * 1986-10-18 1986-11-19 Wellcome Found Compounds
US4871743A (en) * 1988-01-19 1989-10-03 The Trustees Of Princeton University L-glutamic acid derivatives
JPH029869A (ja) * 1988-04-15 1990-01-12 Wellcome Found Ltd:The 新規化合物
US4921836A (en) * 1989-05-17 1990-05-01 Burroughs Wellcome Co. Substituted glutamic acids
US4971973A (en) * 1989-05-17 1990-11-20 Burroughs Wellcome Co. Glutamic acid derivatives
US4920125A (en) * 1989-08-29 1990-04-24 The Trustees Of Princeton University L-glutamic acid derivatives
US5013738A (en) * 1990-04-18 1991-05-07 The Trustees Of Princeton University L-glutamic acid derivatives
CA2047597A1 (en) * 1990-07-24 1992-01-25 Atsushi Goh Halogen-containing compounds, herbicidal composition containing the same as an active ingredient, and intermediary compounds therefor
WO1994013295A1 (en) 1992-12-16 1994-06-23 Agouron Pharmaceuticals, Inc. Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
US5945427A (en) 1995-06-07 1999-08-31 Agouron Pharmaceuticals, Inc. Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
US5426110A (en) * 1993-10-06 1995-06-20 Eli Lilly And Company Pyrimidinyl-glutamic acid derivatives

Also Published As

Publication number Publication date
US20020173515A1 (en) 2002-11-21
EP0674516A4 (da) 1995-10-25
PT674516E (pt) 2000-05-31
US6323210B2 (en) 2001-11-27
GR3033314T3 (en) 2000-09-29
CA2151588A1 (en) 1994-06-23
AU5846494A (en) 1994-07-04
DE69327796D1 (de) 2000-03-09
US5739141A (en) 1998-04-14
SG52739A1 (en) 1998-09-28
US6207670B1 (en) 2001-03-27
US20010018443A1 (en) 2001-08-30
WO1994013295A1 (en) 1994-06-23
EP0674516A1 (en) 1995-10-04
CA2151588C (en) 2002-03-19
ATE189390T1 (de) 2000-02-15
JPH08504765A (ja) 1996-05-21
US5726312A (en) 1998-03-10
ES2145122T3 (es) 2000-07-01
DE69327796T2 (de) 2000-06-21
EP0674516B1 (en) 2000-02-02

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