DK0668869T3 - 2-[3-(4-amidinophenyl)]-propionsyrederivater, deres fremstilling og anvendelse - Google Patents

2-[3-(4-amidinophenyl)]-propionsyrederivater, deres fremstilling og anvendelse

Info

Publication number
DK0668869T3
DK0668869T3 DK92913125T DK92913125T DK0668869T3 DK 0668869 T3 DK0668869 T3 DK 0668869T3 DK 92913125 T DK92913125 T DK 92913125T DK 92913125 T DK92913125 T DK 92913125T DK 0668869 T3 DK0668869 T3 DK 0668869T3
Authority
DK
Denmark
Prior art keywords
amidinophenyl
preparation
pct
propionic acid
acid derivatives
Prior art date
Application number
DK92913125T
Other languages
Danish (da)
English (en)
Inventor
Helmut Mack
Thomas Pfeiffer
Hans Wolfgang Hoeffken
Hans-Joachim Boehm
Wilfried Hornberger
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of DK0668869T3 publication Critical patent/DK0668869T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK92913125T 1991-07-03 1992-06-23 2-[3-(4-amidinophenyl)]-propionsyrederivater, deres fremstilling og anvendelse DK0668869T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4121947A DE4121947A1 (de) 1991-07-03 1991-07-03 2-(3-(4-amidino-phenyl))-propionsaeurederivate, ihre herstellung und verwendung
PCT/EP1992/001411 WO1993001208A1 (de) 1991-07-03 1992-06-23 2-[3-(4-amidino-phenyl)]-propionsäurederivate, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
DK0668869T3 true DK0668869T3 (da) 1998-10-07

Family

ID=6435299

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92913125T DK0668869T3 (da) 1991-07-03 1992-06-23 2-[3-(4-amidinophenyl)]-propionsyrederivater, deres fremstilling og anvendelse

Country Status (10)

Country Link
US (1) US5489583A (es)
EP (1) EP0668869B1 (es)
JP (1) JP3330600B2 (es)
AT (1) ATE166065T1 (es)
CA (1) CA2112580A1 (es)
DE (2) DE4121947A1 (es)
DK (1) DK0668869T3 (es)
ES (1) ES2115673T3 (es)
MX (1) MX9203910A (es)
WO (1) WO1993001208A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5731315A (en) * 1995-06-07 1998-03-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted sulfonic acid n- (aminoiminomethyl)phenylalkyl!-azaheterocyclamide compounds
US5612353A (en) * 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
IT1277405B1 (it) * 1995-08-01 1997-11-10 Menarini Farma Ind Derivati di lattami biciclici come inibitori della trombina
AU3496297A (en) * 1996-06-25 1998-01-14 Eli Lilly And Company Anticoagulant agents
US6200967B1 (en) 1996-06-25 2001-03-13 Eli Lilly And Company Anticoagulant agents
US6602864B1 (en) * 1996-12-13 2003-08-05 Aventis Pharma Deutschland Gmbh Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds
EP0944386B1 (en) * 1996-12-13 2002-09-18 Aventis Pharmaceuticals Inc. Sulfonic acid or sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds
ES2255733T3 (es) * 1997-09-30 2006-07-01 Daiichi Pharmaceutical Co., Ltd. Derivados sulfonilo.
DE19809539A1 (de) 1998-03-05 1999-09-09 Basf Ag Verfahren zur Herstellung von Doppelmetallcyanidkatalysatoren
CA2340100A1 (en) 1998-08-11 2000-02-24 Daiichi Pharmaceutical Co., Ltd. Novel sulfonyl derivatives
CN1373755A (zh) 1999-09-13 2002-10-09 三维药物公司 氮杂环烷酮丝氨酸蛋白酶抑制剂
US6544981B2 (en) 2000-06-09 2003-04-08 Bristol-Myers Squibb Company Lactam inhibitors of factor Xa and method
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
WO2002060894A2 (en) 2001-01-30 2002-08-08 Bristol-Myers Squibb Company Sulfonamide lactam inhibitors of factor xa
GB0114005D0 (en) * 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
GB0114004D0 (en) * 2001-06-08 2001-08-01 Glaxo Group Ltd Chemical compounds
GB0127568D0 (en) * 2001-11-16 2002-01-09 Glaxo Group Ltd Chemical compounds
GB0228552D0 (en) * 2002-12-06 2003-01-15 Glaxo Group Ltd Chemical compounds
EP2606893A1 (en) * 2011-12-21 2013-06-26 Sanofi Sulphonylaminopyrrolidinone derivatives, their preparation and their therapeutic application

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT84170B (pt) * 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas

Also Published As

Publication number Publication date
EP0668869B1 (de) 1998-05-13
US5489583A (en) 1996-02-06
JPH06509076A (ja) 1994-10-13
CA2112580A1 (en) 1993-01-21
EP0668869A1 (de) 1995-08-30
ATE166065T1 (de) 1998-05-15
DE4121947A1 (de) 1993-01-07
WO1993001208A1 (de) 1993-01-21
DE59209327D1 (de) 1998-06-18
JP3330600B2 (ja) 2002-09-30
ES2115673T3 (es) 1998-07-01
MX9203910A (es) 1993-01-01

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