DK0646038T3 - Passiverede og stabiliserede porøse bærere og fremgangsmåder til fremstilling og anvendelse deraf - Google Patents

Passiverede og stabiliserede porøse bærere og fremgangsmåder til fremstilling og anvendelse deraf

Info

Publication number
DK0646038T3
DK0646038T3 DK93915384T DK93915384T DK0646038T3 DK 0646038 T3 DK0646038 T3 DK 0646038T3 DK 93915384 T DK93915384 T DK 93915384T DK 93915384 T DK93915384 T DK 93915384T DK 0646038 T3 DK0646038 T3 DK 0646038T3
Authority
DK
Denmark
Prior art keywords
processes
preparation
passivated
biomolecules
passivation
Prior art date
Application number
DK93915384T
Other languages
English (en)
Inventor
Egisto Boschetti
Pierre Girot
Original Assignee
Life Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/956,404 external-priority patent/US5268097A/en
Application filed by Life Technologies Inc filed Critical Life Technologies Inc
Application granted granted Critical
Publication of DK0646038T3 publication Critical patent/DK0646038T3/da

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804Affinity chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/103Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004Sorbent size or size distribution, e.g. particle size
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057Surface area, e.g. B.E.T specific surface area
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28069Pore volume, e.g. total pore volume, mesopore volume, micropore volume
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078Pore diameter
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/288Polar phases
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30Processes for preparing, regenerating, or reactivating
    • B01J20/32Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204Inorganic carriers, supports or substrates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30Processes for preparing, regenerating, or reactivating
    • B01J20/32Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206Organic carriers, supports or substrates
    • B01J20/3208Polymeric carriers, supports or substrates
    • B01J20/321Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30Processes for preparing, regenerating, or reactivating
    • B01J20/32Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268Macromolecular compounds
    • B01J20/327Polymers obtained by reactions involving only carbon to carbon unsaturated bonds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30Processes for preparing, regenerating, or reactivating
    • B01J20/32Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3289Coatings involving more than one layer of same or different nature
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/16Organic material
    • B01J39/17Organic material containing also inorganic materials, e.g. inert material coated with an ion-exchange resin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26Cation exchangers for chromatographic processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20Anion exchangers for chromatographic processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00Aspects relating to sorbent materials
    • B01J2220/50Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54Sorbents specially adapted for analytical or investigative chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00Aspects relating to sorbent materials
    • B01J2220/50Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58Use in a single column

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Materials For Medical Uses (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
DK93915384T 1992-06-19 1993-06-18 Passiverede og stabiliserede porøse bærere og fremgangsmåder til fremstilling og anvendelse deraf DK0646038T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US90132692A 1992-06-19 1992-06-19
US95593592A 1992-10-05 1992-10-05
US07/956,404 US5268097A (en) 1992-06-19 1992-10-05 Passivated and stabilized porous mineral oxide supports and method for the preparation and use of same
PCT/US1993/005793 WO1994000214A1 (en) 1992-06-19 1993-06-18 Passivated and stabilized porous supports and methods for the preparation and use of same

Publications (1)

Publication Number Publication Date
DK0646038T3 true DK0646038T3 (da) 2001-02-12

Family

ID=27420589

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93915384T DK0646038T3 (da) 1992-06-19 1993-06-18 Passiverede og stabiliserede porøse bærere og fremgangsmåder til fremstilling og anvendelse deraf

Country Status (8)

Country Link
EP (1) EP0646038B1 (da)
JP (1) JP3112682B2 (da)
AT (1) ATE197556T1 (da)
AU (1) AU681590B2 (da)
CA (1) CA2138520C (da)
DE (1) DE69329676T2 (da)
DK (1) DK0646038T3 (da)
WO (1) WO1994000214A1 (da)

Families Citing this family (16)

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AU2952395A (en) * 1994-07-05 1996-01-25 Hybridon, Inc. Purification of oligodeoxynucleotide phosphorothioates using deae 5pw anion ion-exchange chromatography and hydrophobic interaction chromatography
WO2000050160A1 (en) * 1999-02-25 2000-08-31 Pall Corporation Negatively charged membrane
JP2001083162A (ja) * 1999-09-17 2001-03-30 Fuji Photo Film Co Ltd 膜状生体高分子吸着材及び吸着用キット
WO2001029132A1 (fr) * 1999-10-21 2001-04-26 Daiso Co., Ltd. Agent de reticulation a base de compose d'ether de polyallyle
US7674835B2 (en) 2005-12-21 2010-03-09 3M Innovative Properties Company Method of making macroporous anion exchange resins
US7683100B2 (en) * 2005-12-21 2010-03-23 3M Innovative Properties Company Method of making macroporous cation exchange resins
US7674836B2 (en) 2006-07-28 2010-03-09 3M Innovative Properties Company Method of making macroporous cation exchange resins
JP5635725B2 (ja) * 2007-03-27 2014-12-03 株式会社セルシード 生理活性高分子物質の分離方法
SG149759A1 (en) * 2007-07-10 2009-02-27 Millipore Corp Media for affinity chromatography
CN102046284B (zh) * 2008-03-28 2013-10-16 百特基公司 复合材料
EP2545989A1 (en) * 2011-07-13 2013-01-16 InstrAction GmbH Composite material for chromatographic applications
JP6141838B2 (ja) * 2011-07-13 2017-06-07 インストラクション・ゲーエムベーハー クロマトグラフィー用複合材料
KR101813369B1 (ko) 2016-04-08 2017-12-28 서울대학교산학협력단 정삼투막
JP2021121411A (ja) * 2018-04-16 2021-08-26 Agc株式会社 サイズ排除クロマトグラフィ担体、その製造方法、および微小物質の回収方法
JP2021121421A (ja) * 2020-01-31 2021-08-26 学校法人昭和大学 ナノ粒子分離用カラム
US20240173692A1 (en) * 2021-03-26 2024-05-30 Toray Industries, Inc. Porous adsorbent material, separation column using same for purifying biopharmaceutical, and method of manufacturing biopharmaceutical

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Publication number Priority date Publication date Assignee Title
US4335017A (en) * 1975-12-15 1982-06-15 United Kingdom Atomic Energy Authority Composite materials comprising deformable xerogel within the pores of particulate rigid supports useful in chromatography
FR2422720A2 (fr) * 1977-04-26 1979-11-09 Elf Aquitaine Separation et purification de proteines par chromatographie
US4245005A (en) * 1979-02-28 1981-01-13 Purdue Research Foundation Pellicular coated support and method
JPS56115727A (en) * 1980-02-19 1981-09-11 Kuraray Co Ltd Carrier for immobilizing physiologically active substance
US4451568A (en) * 1981-07-13 1984-05-29 Battelle Memorial Institute Composition for binding bioactive substances
FR2541593B1 (fr) * 1983-02-25 1988-06-17 Rhone Poulenc Spec Chim Support mineral poreux pour la purification et le fractionnement des macromolecules biologiques
DE3407814A1 (de) * 1984-03-02 1985-09-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Phasentraeger fuer die verteilungschromatographie von makromolekuelen, verfahren zu ihrer herstellung und ihre verwendung
US4729834A (en) * 1984-05-07 1988-03-08 Mitsui Toatsu Chemicals, Inc. Method for adsorbing and desorbing
US4920152A (en) * 1986-05-13 1990-04-24 Purdue Research Foundation Reversed-phase packing material and method
FR2616437B1 (fr) * 1987-06-11 1990-09-07 Ibf Polymeres composites, leur preparation et leur utilisation en chromatographie liquide
FR2631849B1 (fr) * 1988-05-30 1992-02-14 Centre Nat Rech Scient Support pour la separation des proteines, procede pour sa preparation et application en chromatographie
FR2635019B1 (fr) * 1988-08-02 1992-06-12 Centre Nat Rech Scient Materiau capable de fixer les substances biologiques, et ses applications notamment comme support de chromatographie d'affinite
US5135650A (en) * 1988-12-22 1992-08-04 Bio-Rad Laboratories, Inc. Chromatography stationary phase material for high performance liquid chromatography
US5030352A (en) * 1990-01-25 1991-07-09 Purdue Research Foundation Coated media for chromatography
US5137633A (en) * 1991-06-26 1992-08-11 Millipore Corporation Hydrophobic membrane having hydrophilic and charged surface and process

Also Published As

Publication number Publication date
EP0646038A4 (en) 1995-06-28
AU681590B2 (en) 1997-09-04
CA2138520A1 (en) 1994-01-06
JPH07509173A (ja) 1995-10-12
EP0646038B1 (en) 2000-11-15
AU4538493A (en) 1994-01-24
JP3112682B2 (ja) 2000-11-27
ATE197556T1 (de) 2000-12-15
DE69329676T2 (de) 2001-03-15
EP0646038A1 (en) 1995-04-05
WO1994000214A1 (en) 1994-01-06
DE69329676D1 (de) 2000-12-21
CA2138520C (en) 2001-02-06

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