DK0579713T3 - Fremgangsmåde til påvisning af mutationer i et transgent pattedyrs eller en transgen pattedyrcelles DNA - Google Patents
Fremgangsmåde til påvisning af mutationer i et transgent pattedyrs eller en transgen pattedyrcelles DNAInfo
- Publication number
- DK0579713T3 DK0579713T3 DK92909305.2T DK92909305T DK0579713T3 DK 0579713 T3 DK0579713 T3 DK 0579713T3 DK 92909305 T DK92909305 T DK 92909305T DK 0579713 T3 DK0579713 T3 DK 0579713T3
- Authority
- DK
- Denmark
- Prior art keywords
- plasmid
- dna
- lacz
- pct
- transgenic
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 title abstract 3
- 230000035772 mutation Effects 0.000 title abstract 3
- 230000009261 transgenic effect Effects 0.000 title abstract 3
- 210000004962 mammalian cell Anatomy 0.000 title abstract 2
- 239000013612 plasmid Substances 0.000 abstract 6
- 101150066555 lacZ gene Proteins 0.000 abstract 5
- 239000002245 particle Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
- G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL9100567A NL9100567A (nl) | 1991-04-02 | 1991-04-02 | Werkwijze voor het detecteren van mutaties, transgeen zoogdier, transgene zoogdiercel, en werkwijze voor het onderzoeken van stoffen of omstandigheden op mutagene eigenschappen. |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0579713T3 true DK0579713T3 (da) | 1995-12-04 |
Family
ID=19859081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92909305.2T DK0579713T3 (da) | 1991-04-02 | 1992-04-02 | Fremgangsmåde til påvisning af mutationer i et transgent pattedyrs eller en transgen pattedyrcelles DNA |
Country Status (10)
Country | Link |
---|---|
US (1) | US5602300A (nl) |
EP (1) | EP0579713B1 (nl) |
JP (1) | JPH06506357A (nl) |
AT (1) | ATE128735T1 (nl) |
DE (1) | DE69205277T2 (nl) |
DK (1) | DK0579713T3 (nl) |
ES (1) | ES2078043T3 (nl) |
GR (1) | GR3017795T3 (nl) |
NL (1) | NL9100567A (nl) |
WO (1) | WO1992017605A1 (nl) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991015579A1 (en) * | 1990-04-05 | 1991-10-17 | Stratagene | Mutagenesis testing using transgenic non-human animals carrying test dna sequences |
CA2130081A1 (en) * | 1992-02-14 | 1993-08-19 | Jay M. Short | Mutagenesis testing using transgenic non-human animals carrying test dna sequences |
EP0680517B2 (en) * | 1993-01-21 | 2005-01-19 | President And Fellows Of Harvard College | Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound |
JPH11510692A (ja) * | 1995-07-28 | 1999-09-21 | ベス イスラエル ディーコネス メディカル センター,インク. | 突然変異誘発を検査するための方法及び検査器具 |
US6063359A (en) * | 1997-09-26 | 2000-05-16 | Washington University | Method for determining oncogenic activity of a substance |
US6307121B1 (en) | 1998-05-31 | 2001-10-23 | The University Of Georgia Research Foundation, Inc. | Bacteriophage-based transgenic fish for mutation detection |
AU1323000A (en) | 1998-10-26 | 2000-05-15 | University Of Georgia Research Foundation, Inc., The | Transgenic fish carrying plasmid for mutation detection and methods |
GB9826247D0 (en) * | 1998-11-30 | 1999-01-20 | Nycomed Pharma As | Method |
EP1176211A1 (en) * | 2000-07-27 | 2002-01-30 | Novartis Forschungsstiftung, c/o Novartis International AG | Process for monitoring mutagens in plants |
WO2021050227A1 (en) | 2019-09-13 | 2021-03-18 | Exxonmobil Chemical Patents Inc. | Slurry loop reactor polymerization rate and quality controller |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4753874A (en) * | 1985-07-08 | 1988-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Rapid mutation testing system for human cells |
US5128256A (en) * | 1987-01-12 | 1992-07-07 | Stratagene | DNA cloning vectors with in vivo excisable plasmids |
EP0289121B1 (en) * | 1987-05-01 | 1995-12-27 | Stratagene | Mutagenesis testing using transgenic non-human animals carrying test DNA sequences |
WO1989009272A1 (en) * | 1988-03-22 | 1989-10-05 | Chemical Industry Institute Of Toxicology | A transgenic mouse for measurement and characterization of mutation induction in vivo |
NL8801826A (nl) * | 1988-07-19 | 1990-02-16 | Tno | Werkwijze voor het detecteren van mutaties in markergenen. |
EP0370813A3 (en) * | 1988-11-25 | 1991-06-19 | Exemplar Corporation | Rapid screening mutagenesis and teratogenesis assay |
-
1991
- 1991-04-02 NL NL9100567A patent/NL9100567A/nl not_active Application Discontinuation
-
1992
- 1992-04-02 WO PCT/NL1992/000062 patent/WO1992017605A1/en active IP Right Grant
- 1992-04-02 ES ES92909305T patent/ES2078043T3/es not_active Expired - Lifetime
- 1992-04-02 EP EP92909305A patent/EP0579713B1/en not_active Expired - Lifetime
- 1992-04-02 AT AT92909305T patent/ATE128735T1/de not_active IP Right Cessation
- 1992-04-02 US US08/122,562 patent/US5602300A/en not_active Expired - Fee Related
- 1992-04-02 DE DE69205277T patent/DE69205277T2/de not_active Expired - Fee Related
- 1992-04-02 JP JP4508708A patent/JPH06506357A/ja active Pending
- 1992-04-02 DK DK92909305.2T patent/DK0579713T3/da active
-
1995
- 1995-10-18 GR GR950402898T patent/GR3017795T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5602300A (en) | 1997-02-11 |
DE69205277T2 (de) | 1996-03-21 |
ES2078043T3 (es) | 1995-12-01 |
GR3017795T3 (en) | 1996-01-31 |
JPH06506357A (ja) | 1994-07-21 |
ATE128735T1 (de) | 1995-10-15 |
EP0579713B1 (en) | 1995-10-04 |
DE69205277D1 (de) | 1995-11-09 |
EP0579713A1 (en) | 1994-01-26 |
NL9100567A (nl) | 1992-11-02 |
WO1992017605A1 (en) | 1992-10-15 |
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