DK0557345T3 - 1,3-bis- (3- (mono- or polyhydroxy) acylamino-5- (mono- or polyhydroxyalkyl) aminocarbonyl-2,4,6-triiodobenzoylamino) -hydroxy- or hydroxyalkyl-propanes, processes for their preparation and X-ray contrast agents containing these - Google Patents

1,3-bis- (3- (mono- or polyhydroxy) acylamino-5- (mono- or polyhydroxyalkyl) aminocarbonyl-2,4,6-triiodobenzoylamino) -hydroxy- or hydroxyalkyl-propanes, processes for their preparation and X-ray contrast agents containing these

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Publication number
DK0557345T3
DK0557345T3 DK91919864.8T DK91919864T DK0557345T3 DK 0557345 T3 DK0557345 T3 DK 0557345T3 DK 91919864 T DK91919864 T DK 91919864T DK 0557345 T3 DK0557345 T3 DK 0557345T3
Authority
DK
Denmark
Prior art keywords
mono
hydroxy
propanes
polyhydroxyalkyl
aminocarbonyl
Prior art date
Application number
DK91919864.8T
Other languages
Danish (da)
Inventor
Fulvio Uggeri
Marino Brocchetta
Original Assignee
Dibra Spa
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dibra Spa, Bracco Spa filed Critical Dibra Spa
Application granted granted Critical
Publication of DK0557345T3 publication Critical patent/DK0557345T3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Symmetrical or asymmetrical 1,3-bis-[3-(mono- or poly-hydroxy)acylamino-5-(mono- or polyhydroxyalkyl)-aminocarbonyl-2,4,6-triiodo-benzoyl-amino]-hydroxy- or hydroxyalkyl-propanes, useful to constitute the opacifying component of X-ray contrast media, are described.
DK91919864.8T 1990-11-16 1991-11-15 1,3-bis- (3- (mono- or polyhydroxy) acylamino-5- (mono- or polyhydroxyalkyl) aminocarbonyl-2,4,6-triiodobenzoylamino) -hydroxy- or hydroxyalkyl-propanes, processes for their preparation and X-ray contrast agents containing these DK0557345T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02208890A IT1245853B (en) 1990-11-16 1990-11-16 1,3-BIS (3- (MONO OR POLYHYDROXY) ACYLAMINE-5- (MONO OR POLYHYDROXY-ALCHYL) AMINOCARBONYL-2,4,6-TRIIODE-BENZOYL-AMINO) -HYDROXY- OR HYDROXY-ALCHYL-PROPANE, THEIR METHOD OF PREPARATION AND ROENTGENOGRAPHIC CONTRAST MEANS THAT CONTAIN THEM

Publications (1)

Publication Number Publication Date
DK0557345T3 true DK0557345T3 (en) 1995-03-06

Family

ID=11191331

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91919864.8T DK0557345T3 (en) 1990-11-16 1991-11-15 1,3-bis- (3- (mono- or polyhydroxy) acylamino-5- (mono- or polyhydroxyalkyl) aminocarbonyl-2,4,6-triiodobenzoylamino) -hydroxy- or hydroxyalkyl-propanes, processes for their preparation and X-ray contrast agents containing these

Country Status (19)

Country Link
EP (1) EP0557345B1 (en)
JP (1) JP2977613B2 (en)
KR (1) KR930702281A (en)
AT (1) ATE111441T1 (en)
AU (1) AU646119B2 (en)
CA (1) CA2096136A1 (en)
DE (2) DE69104059T2 (en)
DK (1) DK0557345T3 (en)
ES (1) ES2060415T3 (en)
GR (1) GR930300134T1 (en)
HU (1) HUT65652A (en)
IE (1) IE66460B1 (en)
IL (1) IL100054A (en)
IS (1) IS3781A7 (en)
IT (1) IT1245853B (en)
MX (1) MX9102103A (en)
NZ (1) NZ240566A (en)
WO (1) WO1992008691A1 (en)
ZA (1) ZA919065B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2717799B1 (en) * 1994-03-22 1996-07-19 Guerbet Sa Polyiodes compounds: preparation process; diagnostic composition.
ES2341296T3 (en) 2001-12-20 2010-06-17 Bone Support Ab A NEW BONE MINERAL SUBSTITUTE.
ATE430146T1 (en) 2004-07-02 2009-05-15 Bracco Imaging Spa HIGH RELAXIVITY CONTRAST AGENT FOR USE IN MAGNETIC RESONANCE IMAGING (MRI), CONTAINING A CHELATING GROUP WITH POLYHYDROXYLATED SUBSTITUENTS
US7407647B2 (en) * 2005-12-07 2008-08-05 Cordis Corporation Organic radiographic contrasting agents for medical devices
US20070134163A1 (en) 2005-12-13 2007-06-14 Zhao Jonathon Z Radiographic contrasting agents and radio-opaque polymeric materials for medical devices
ES2396567T3 (en) * 2006-02-14 2013-02-22 Ge Healthcare As Contrast agents
US8920780B2 (en) 2007-07-12 2014-12-30 Ge Healthcare As Contrast agents
CN101820922A (en) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 Contrast agents
WO2009047315A1 (en) 2007-10-12 2009-04-16 Ge Healthcare As Contrast agents
CN101820923A (en) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 Contrast medium
GB2453654A (en) * 2007-10-12 2009-04-15 Ge Healthcare As A compound for use in X-ray contrast examinations
CN101821231A (en) * 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 Contrast agents
WO2009056555A1 (en) * 2007-10-30 2009-05-07 Ge Healthcare As Contrast agents
CN101888858A (en) * 2007-12-05 2010-11-17 通用电气医疗集团股份有限公司 Contrast agent
EP2247314A4 (en) * 2008-02-01 2013-11-27 Univ Boston Cationic contrast agents and methods of use thereof
US20110021824A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Adsorptive purification method for iodixanol
CN107249570B (en) 2014-11-21 2022-08-09 丹麦技术大学 Gel formulations for topical drug delivery
US10610366B2 (en) 2015-01-29 2020-04-07 Theracell, Inc. Demineralized bone fiber composition for use in minimally invasive surgery
SG11201809729XA (en) 2016-05-20 2018-12-28 Univ Denmark Tech Dtu Palpable marker composition
US10639157B2 (en) 2017-03-14 2020-05-05 Theracell, Inc. Demineralized bone fiber composition for use in minimally invasive surgery
EP3982922A1 (en) 2019-06-12 2022-04-20 Technical University of Denmark Dissacharide formulations for controlled drug release

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1491129A (en) * 1975-06-04 1977-11-09 Guerbet Sa Iodo-benzene derivatives and an x-ray contrast medium containing them
CH626873A5 (en) * 1977-03-28 1981-12-15 Bracco Ind Chimica Spa
US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
DE3731542A1 (en) * 1987-09-17 1989-03-30 Schering Ag NEW DICARBONIC ACID-BIS (3,5-DICARBAMOYL-2,4,6-TRIIOD-ANILIDE), METHOD FOR THE PRODUCTION THEREOF AND THESE CONTAINING X-RAY AGENTS

Also Published As

Publication number Publication date
EP0557345B1 (en) 1994-09-14
DE557345T1 (en) 1994-07-28
IE66460B1 (en) 1995-12-27
IE913986A1 (en) 1992-05-20
ATE111441T1 (en) 1994-09-15
HUT65652A (en) 1994-07-28
AU646119B2 (en) 1994-02-10
MX9102103A (en) 1992-06-01
WO1992008691A1 (en) 1992-05-29
CA2096136A1 (en) 1992-05-17
DE69104059T2 (en) 1995-02-02
ZA919065B (en) 1992-08-26
EP0557345A1 (en) 1993-09-01
JPH06504268A (en) 1994-05-19
IT9022088A0 (en) 1990-11-16
DE69104059D1 (en) 1994-10-20
IS3781A7 (en) 1992-05-17
IT9022088A1 (en) 1992-05-17
ES2060415T3 (en) 1994-11-16
IL100054A (en) 1996-05-14
HU9301375D0 (en) 1993-09-28
JP2977613B2 (en) 1999-11-15
IL100054A0 (en) 1992-08-18
AU8925391A (en) 1992-06-11
KR930702281A (en) 1993-09-08
NZ240566A (en) 1994-02-25
IT1245853B (en) 1994-10-25
GR930300134T1 (en) 1994-02-28

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