DK0551438T3 - Overfladeekspressionsbiblioteker af randomiserede peptider - Google Patents
Overfladeekspressionsbiblioteker af randomiserede peptiderInfo
- Publication number
- DK0551438T3 DK0551438T3 DK91920120T DK91920120T DK0551438T3 DK 0551438 T3 DK0551438 T3 DK 0551438T3 DK 91920120 T DK91920120 T DK 91920120T DK 91920120 T DK91920120 T DK 91920120T DK 0551438 T3 DK0551438 T3 DK 0551438T3
- Authority
- DK
- Denmark
- Prior art keywords
- surface expression
- expression libraries
- randomized peptides
- randomized
- peptides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/675—Beta-endorphins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59066490A | 1990-09-28 | 1990-09-28 | |
PCT/US1991/007141 WO1992006176A1 (en) | 1990-09-28 | 1991-09-27 | Surface expression libraries of randomized peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0551438T3 true DK0551438T3 (da) | 2005-03-21 |
Family
ID=24363161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91920120T DK0551438T3 (da) | 1990-09-28 | 1991-09-27 | Overfladeekspressionsbiblioteker af randomiserede peptider |
Country Status (12)
Country | Link |
---|---|
EP (2) | EP0551438B1 (xx) |
JP (3) | JP3663515B2 (xx) |
AT (1) | ATE283352T1 (xx) |
AU (1) | AU655788B2 (xx) |
CA (1) | CA2092803A1 (xx) |
DE (1) | DE69133430T2 (xx) |
DK (1) | DK0551438T3 (xx) |
ES (1) | ES2233922T3 (xx) |
IE (2) | IE20060477A1 (xx) |
IL (1) | IL99553A0 (xx) |
NZ (1) | NZ239987A (xx) |
WO (1) | WO1992006176A1 (xx) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US7413537B2 (en) | 1989-09-01 | 2008-08-19 | Dyax Corp. | Directed evolution of disulfide-bonded micro-proteins |
US5747334A (en) * | 1990-02-15 | 1998-05-05 | The University Of North Carolina At Chapel Hill | Random peptide library |
US5498538A (en) * | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
ES2330052T3 (es) | 1991-03-01 | 2009-12-03 | Dyax Corporation | Proteina quimerica que comprende micro-proteinas que tienen dos o mas puentes disulfuro y relaizaciones de las mismas. |
US5639603A (en) * | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
AU669489B2 (en) * | 1991-09-18 | 1996-06-13 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
CA2148838A1 (en) * | 1992-11-10 | 1994-05-26 | William D. Huse | Soluble peptides having constrained, secondary conformation in solution and method of making same |
IT1270939B (it) * | 1993-05-11 | 1997-05-26 | Angeletti P Ist Richerche Bio | Procedimento per la preparazione di immunogeni e reagenti diagnostici,e immunogeni e reagenti diagnostici cosi' ottenibili. |
JPH09504522A (ja) * | 1993-10-12 | 1997-05-06 | グリコメド・インコーポレイテッド | 細胞接着インヒビターの同定に有用なグリコ−ペプチドのライブラリー |
US6165778A (en) * | 1993-11-02 | 2000-12-26 | Affymax Technologies N.V. | Reaction vessel agitation apparatus |
US5503805A (en) * | 1993-11-02 | 1996-04-02 | Affymax Technologies N.V. | Apparatus and method for parallel coupling reactions |
US5605793A (en) * | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6010861A (en) * | 1994-08-03 | 2000-01-04 | Dgi Biotechnologies, Llc | Target specific screens and their use for discovering small organic molecular pharmacophores |
ATE235504T1 (de) * | 1994-12-30 | 2003-04-15 | Chiron Corp | Verfahren zur kontrollierten synthese von beliebigen peptidmischungen kodierende polynukleotidmischungen |
US6096548A (en) | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
US6310191B1 (en) | 1998-02-02 | 2001-10-30 | Cosmix Molecular Biologicals Gmbh | Generation of diversity in combinatorial libraries |
WO1998033901A2 (en) * | 1997-01-31 | 1998-08-06 | Cosmix Molecular Biologicals Gmbh | Generation of diversity in combinatorial libraries |
US6153410A (en) * | 1997-03-25 | 2000-11-28 | California Institute Of Technology | Recombination of polynucleotide sequences using random or defined primers |
EP1690868A1 (en) | 1997-10-31 | 2006-08-16 | Maxygen, Inc. | Modification of virus tropism and host range by viral genome shuffling |
US7244826B1 (en) | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
AU5122499A (en) | 1998-07-27 | 2000-02-21 | Genentech Inc. | Improved transformation efficiency in phage display through modification of a coat protein |
KR20010085850A (ko) * | 1998-09-29 | 2001-09-07 | 추후제출 | 코돈 변형 유전자의 재편성 |
US6368861B1 (en) | 1999-01-19 | 2002-04-09 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6917882B2 (en) | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US6436675B1 (en) | 1999-09-28 | 2002-08-20 | Maxygen, Inc. | Use of codon-varied oligonucleotide synthesis for synthetic shuffling |
US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US8457903B1 (en) | 1999-01-19 | 2013-06-04 | Codexis Mayflower Holdings, Llc | Method and/or apparatus for determining codons |
US6961664B2 (en) | 1999-01-19 | 2005-11-01 | Maxygen | Methods of populating data structures for use in evolutionary simulations |
US7702464B1 (en) | 2001-08-21 | 2010-04-20 | Maxygen, Inc. | Method and apparatus for codon determining |
US7024312B1 (en) | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US7873477B1 (en) | 2001-08-21 | 2011-01-18 | Codexis Mayflower Holdings, Llc | Method and system using systematically varied data libraries |
US20070065838A1 (en) | 1999-01-19 | 2007-03-22 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
EP1072010B1 (en) | 1999-01-19 | 2010-04-21 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
AU3719500A (en) | 1999-03-05 | 2000-09-21 | Maxygen, Inc. | Recombination of insertion modified nucleic acids |
US7430477B2 (en) | 1999-10-12 | 2008-09-30 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
AU2001247616B2 (en) | 2000-04-11 | 2007-06-14 | Genentech, Inc. | Multivalent antibodies and uses therefor |
DK1303293T3 (da) | 2000-07-27 | 2009-03-30 | Genentech Inc | Sekventiel indgivelse af CPT-11 og APO-2L-polypeptid |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
BR8108073A (pt) * | 1980-12-12 | 1982-09-21 | Unilever Nv | Sequencias de dna;plasmidios recombinantes;cultura bacteriana;e processo para a producao de preprotaumatina,pretaumatina ou protaumatina |
EP1892296A1 (en) * | 1988-09-02 | 2008-02-27 | Dyax Corporation | Generation and selection of recombinant varied binding proteins |
CA2009996A1 (en) * | 1989-02-17 | 1990-08-17 | Kathleen S. Cook | Process for making genes encoding random polymers of amino acids |
-
1991
- 1991-09-24 IL IL99553A patent/IL99553A0/xx unknown
- 1991-09-27 EP EP91920120A patent/EP0551438B1/en not_active Expired - Lifetime
- 1991-09-27 DK DK91920120T patent/DK0551438T3/da active
- 1991-09-27 AT AT91920120T patent/ATE283352T1/de not_active IP Right Cessation
- 1991-09-27 EP EP04015895A patent/EP1479770A1/en not_active Withdrawn
- 1991-09-27 WO PCT/US1991/007141 patent/WO1992006176A1/en active IP Right Grant
- 1991-09-27 IE IE20060477A patent/IE20060477A1/en not_active Application Discontinuation
- 1991-09-27 ES ES91920120T patent/ES2233922T3/es not_active Expired - Lifetime
- 1991-09-27 AU AU89223/91A patent/AU655788B2/en not_active Ceased
- 1991-09-27 IE IE342491A patent/IE913424A1/en not_active IP Right Cessation
- 1991-09-27 JP JP51845391A patent/JP3663515B2/ja not_active Expired - Fee Related
- 1991-09-27 CA CA002092803A patent/CA2092803A1/en not_active Abandoned
- 1991-09-27 NZ NZ239987A patent/NZ239987A/en unknown
- 1991-09-27 DE DE69133430T patent/DE69133430T2/de not_active Expired - Lifetime
-
2003
- 2003-06-23 JP JP2003178804A patent/JP2004024262A/ja active Pending
-
2005
- 2005-05-02 JP JP2005134324A patent/JP2005237389A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP3663515B2 (ja) | 2005-06-22 |
EP0551438A4 (en) | 1994-06-08 |
ES2233922T3 (es) | 2005-06-16 |
DE69133430T2 (de) | 2005-12-08 |
EP0551438A1 (en) | 1993-07-21 |
JPH06504666A (ja) | 1994-06-02 |
IE913424A1 (en) | 1992-04-08 |
DE69133430D1 (de) | 2004-12-30 |
EP1479770A1 (en) | 2004-11-24 |
WO1992006176A1 (en) | 1992-04-16 |
JP2004024262A (ja) | 2004-01-29 |
CA2092803A1 (en) | 1992-03-29 |
IL99553A0 (en) | 1992-08-18 |
NZ239987A (en) | 1994-08-26 |
AU8922391A (en) | 1992-04-28 |
AU655788B2 (en) | 1995-01-12 |
EP0551438B1 (en) | 2004-11-24 |
ATE283352T1 (de) | 2004-12-15 |
JP2005237389A (ja) | 2005-09-08 |
IE20060477A1 (en) | 2006-08-09 |
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