DK0542903T3 - Kokainreceptor-bindingsligander - Google Patents

Kokainreceptor-bindingsligander

Info

Publication number
DK0542903T3
DK0542903T3 DK91916141.4T DK91916141T DK0542903T3 DK 0542903 T3 DK0542903 T3 DK 0542903T3 DK 91916141 T DK91916141 T DK 91916141T DK 0542903 T3 DK0542903 T3 DK 0542903T3
Authority
DK
Denmark
Prior art keywords
pct
beta
sec
binding ligands
cocaine
Prior art date
Application number
DK91916141.4T
Other languages
Danish (da)
English (en)
Inventor
Michael J Kuhar
Frank Ivy Carroll
John W Boja
Anita H Lewin
Philip Abraham
Original Assignee
Res Triangle Inst
Nat Inst Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Triangle Inst, Nat Inst Health filed Critical Res Triangle Inst
Application granted granted Critical
Publication of DK0542903T3 publication Critical patent/DK0542903T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
DK91916141.4T 1990-08-09 1991-08-09 Kokainreceptor-bindingsligander DK0542903T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/564,755 US5128118A (en) 1990-08-09 1990-08-09 Cocaine receptor binding ligands

Publications (1)

Publication Number Publication Date
DK0542903T3 true DK0542903T3 (da) 1997-04-21

Family

ID=24255753

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91916141.4T DK0542903T3 (da) 1990-08-09 1991-08-09 Kokainreceptor-bindingsligander

Country Status (11)

Country Link
US (2) US5128118A (fr)
EP (1) EP0542903B1 (fr)
JP (1) JP3350049B2 (fr)
AT (1) ATE145140T1 (fr)
AU (1) AU650059B2 (fr)
CA (1) CA2089070C (fr)
DE (1) DE69123151T2 (fr)
DK (1) DK0542903T3 (fr)
ES (1) ES2099167T3 (fr)
GR (1) GR3022529T3 (fr)
WO (1) WO1992002260A1 (fr)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
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US6329520B1 (en) 1990-08-09 2001-12-11 Research Triangle Institute Cocaine receptor binding ligands
US6706880B2 (en) 1990-08-09 2004-03-16 Research Triangle Institute Cocaine receptor binding ligands
US6123917A (en) * 1990-08-09 2000-09-26 Research Triangle Institute Method for making cocaine receptor binding ligands and intermediates therefor
US5736123A (en) * 1990-08-09 1998-04-07 Research Triangle Institute Cocaine receptor binding ligands
US5935953A (en) * 1990-08-09 1999-08-10 Research Triangle Institute Methods for controlling invertebrate pests using cocaine receptor binding ligands
US7189737B2 (en) 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US6531483B1 (en) 1990-08-09 2003-03-11 Research Triangle Institute Cocaine receptor binding ligands
US5380848A (en) * 1990-08-09 1995-01-10 Research Triangle Institute Cocaine receptor binding ligands
US5496953A (en) * 1990-08-09 1996-03-05 Research Triangle Institute Cocaine receptor binding ligands
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US7011813B2 (en) * 1990-08-09 2006-03-14 Research Triangle Institute Cocaine receptor binding ligands
EP0905135B1 (fr) * 1991-11-15 2006-09-06 Research Triangle Institute Ligands liant les récepteurs de la cocaine
US5310912A (en) * 1992-02-25 1994-05-10 Research Biochemicals Limited Partnership Iodinated neuroprobe for mapping monoamine reuptake sites
US5750089A (en) * 1996-01-11 1998-05-12 Neuro Imaging Technologies, Llc Halogenated neuroprobe for mapping monoamine reuptake sites
US5698179A (en) * 1992-02-25 1997-12-16 Neuro Imaging Technologies, Llc Iodinated neuroprobe for mapping monoamine reuptake sites
US5262428A (en) * 1992-03-13 1993-11-16 Wake Forest University Biologically active tropane derivatives
US5760055A (en) * 1992-03-13 1998-06-02 Wake Forest University Biologically active tropane derivatives
US5770180A (en) * 1992-08-24 1998-06-23 Organix, Inc. Bridge-substituted tropanes for methods of imaging and therapy
US5506359A (en) * 1992-08-24 1996-04-09 President And Fellows Of Harvard College Cocaine analogues and their use as cocaine drug therapies and therapeutic and imaging agents for neurodegenerative disorders
US6060473A (en) * 1993-04-01 2000-05-09 Ucb S.A. - Dtb 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
US5817679A (en) 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
CA2171440A1 (fr) * 1993-09-10 1995-03-16 Changgeng Qian Epibatidine et ses derives, agonistes et antagonistes du recepteur cholinergique
US5493026A (en) * 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
US5565185A (en) * 1994-07-20 1996-10-15 Merck Frosst Canada, Inc. Process for the preparation of radiolabeled meta-halobenzylguanidine
US5763490A (en) * 1994-09-20 1998-06-09 University Of South Carolina Treating prostate cancer with tartrate ions
EP0831941B1 (fr) * 1995-06-06 2012-04-04 GE Healthcare Limited Neurosondes iodees pour cartographier les sites de reabsorption de la monoamine
US5864038A (en) * 1995-08-17 1999-01-26 Emory University Labeled cocaine analogs
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
US6171576B1 (en) * 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
JP3238414B2 (ja) * 1996-02-22 2001-12-17 ニューロサーチ・アクティーゼルスカブ トロパン―誘導体、その製造方法及びその使用方法
AU5194798A (en) 1996-10-29 1998-05-22 Guilford Pharmaceuticals Inc. Process for the preparation of radiopharmaceuticals
AU7282498A (en) * 1997-05-01 1998-11-24 Emory University Bioactive peptides derived from cocaine and amphetamine regulated transcript protein
US6358492B1 (en) * 1997-10-07 2002-03-19 Research Triangle Institute Dopamine transporter imaging ligand
US6013242A (en) * 1998-01-13 2000-01-11 Wake Forest University Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression
WO1999038866A1 (fr) * 1998-01-28 1999-08-05 Neurosearch A/S Derives de 8-azabicyclo[3.2.1]oct-2-ene sous forme marquee et utilisation de derives de 8-azabicyclo[3.2.1]oct-2-ene sous forme marquee ou non marquee
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
US6399042B1 (en) 1999-04-26 2002-06-04 Emory University 4-fluoroalkyl-3-halophenyl nortropanes
US6843979B2 (en) 1999-04-26 2005-01-18 Emory University 4-haloethenylphenyl tropane:serotonin transporter imaging agents
CA2285516C (fr) * 1999-05-12 2010-12-07 President And Fellows Of Harvard College Agents d'imagerie pour transporteur de dopamine
US6479509B1 (en) 2000-05-22 2002-11-12 Research Triangle Institute Method of promoting smoking cessation
US6538010B1 (en) * 2000-11-08 2003-03-25 Research Triangle Institute Compounds and methods for promoting smoking cessation
DE20120708U1 (de) 2001-10-09 2002-08-01 Meltzer Peter C Tropan-Analoga zur Inhibierung des Monoamin-Transports
WO2003045388A1 (fr) * 2001-11-30 2003-06-05 Neurosearch A/S Derives de tropane possedant une activite inhibitrice de recaptage de dopamine destines au traitement de maladies ischemiques
NZ535333A (en) * 2002-04-30 2007-02-23 Univ Emory Tumor imaging amino acid analog compounds
US7872023B2 (en) * 2005-02-17 2011-01-18 Research Triangle Institute Kappa opioid receptor ligands
US7399762B2 (en) * 2005-04-25 2008-07-15 Research Triangle Institute Opioid receptor agonist compounds and their use in treatment of pain
AU2006262502A1 (en) 2005-06-23 2007-01-04 Emory Univerisity Imaging agents
AU2006262425C1 (en) * 2005-06-23 2012-06-21 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
US7476679B2 (en) * 2005-07-26 2009-01-13 Research Triangle Institute Octahydroisoquinoline compounds as opioid receptor modulators
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
US8048895B2 (en) * 2008-04-18 2011-11-01 Research Triangle Institute Kappa opioid receptor ligands
AU2010346633B2 (en) 2010-02-24 2015-12-03 Research Triangle Institute Arylpiperazine opioid receptor antagonists
CN110582494A (zh) * 2017-03-17 2019-12-17 日本医事物理股份有限公司 碘氟潘的制造方法
KR20200142039A (ko) * 2018-04-10 2020-12-21 스카이호크 테라퓨틱스, 인코포레이티드 암 치료용 화합물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
US4041040A (en) * 1976-09-22 1977-08-09 Hoffmann-La Roche Inc. Ecgonine derivative
US4179567A (en) * 1978-04-10 1979-12-18 Sterling Drug Inc. 2-Aryltropane compounds
US4366154A (en) * 1981-11-09 1982-12-28 Sandoz, Inc. Tropyl derivatives
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US5310912A (en) * 1992-02-25 1994-05-10 Research Biochemicals Limited Partnership Iodinated neuroprobe for mapping monoamine reuptake sites
US5262428A (en) * 1992-03-13 1993-11-16 Wake Forest University Biologically active tropane derivatives
US5288872A (en) * 1992-03-13 1994-02-22 Wake Forest University Compounds for treatment of neurodegenerative diseases

Also Published As

Publication number Publication date
EP0542903A4 (en) 1993-08-04
ES2099167T3 (es) 1997-05-16
DE69123151T2 (de) 1997-03-13
WO1992002260A1 (fr) 1992-02-20
ATE145140T1 (de) 1996-11-15
EP0542903B1 (fr) 1996-11-13
JP3350049B2 (ja) 2002-11-25
CA2089070C (fr) 2003-07-29
AU8519591A (en) 1992-03-02
AU650059B2 (en) 1994-06-09
US5128118A (en) 1992-07-07
JPH06503556A (ja) 1994-04-21
DE69123151D1 (de) 1996-12-19
CA2089070A1 (fr) 1992-02-10
US5413779A (en) 1995-05-09
GR3022529T3 (en) 1997-05-31
EP0542903A1 (fr) 1993-05-26

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