DK0535448T3 - Fremgangsmåde og mellemprodukter til fremstilling af et antiviralt middel indeholdende en cyclobutylgruppe - Google Patents

Fremgangsmåde og mellemprodukter til fremstilling af et antiviralt middel indeholdende en cyclobutylgruppe

Info

Publication number
DK0535448T3
DK0535448T3 DK92115827.5T DK92115827T DK0535448T3 DK 0535448 T3 DK0535448 T3 DK 0535448T3 DK 92115827 T DK92115827 T DK 92115827T DK 0535448 T3 DK0535448 T3 DK 0535448T3
Authority
DK
Denmark
Prior art keywords
preparation
antiviral agent
intermediates
agent containing
acid
Prior art date
Application number
DK92115827.5T
Other languages
English (en)
Inventor
Richard H Mueller
Jollie D Godfrey Jr
Thomas P Kissick
Janak Singh
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Application granted granted Critical
Publication of DK0535448T3 publication Critical patent/DK0535448T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/35—Unsaturated compounds having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/743—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of acids with a three-membered ring and with unsaturation outside the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK92115827.5T 1991-10-02 1992-09-16 Fremgangsmåde og mellemprodukter til fremstilling af et antiviralt middel indeholdende en cyclobutylgruppe DK0535448T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/770,191 US5185463A (en) 1991-10-02 1991-10-02 Process for the preparation of an antiviral agent

Publications (1)

Publication Number Publication Date
DK0535448T3 true DK0535448T3 (da) 1996-07-29

Family

ID=25087756

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92115827.5T DK0535448T3 (da) 1991-10-02 1992-09-16 Fremgangsmåde og mellemprodukter til fremstilling af et antiviralt middel indeholdende en cyclobutylgruppe

Country Status (9)

Country Link
US (1) US5185463A (da)
EP (1) EP0535448B1 (da)
JP (1) JPH05271232A (da)
AT (1) ATE139762T1 (da)
CA (1) CA2079496A1 (da)
DE (1) DE69211799T2 (da)
DK (1) DK0535448T3 (da)
ES (1) ES2089327T3 (da)
GR (1) GR3021125T3 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5412134A (en) * 1992-05-26 1995-05-02 E. R. Squibb & Sons, Inc. Process for preparing diprotected 2,3-hydroxymethyl cyclobutanol
IL117574A0 (en) * 1995-04-03 1996-07-23 Bristol Myers Squibb Co Processes for the preparation of cyclobutanone derivatives
US6353122B1 (en) * 1997-02-26 2002-03-05 Bristol-Myers Squibb Company Method for epoxidation of 3-methylenecyclopropanes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2262652A1 (en) * 1974-02-28 1975-09-26 Rhone Poulenc Ind Resolving optical isomers of cyclonic dicarboxylic acids - by forming salt with alpha-phenyl ethyl amine enantiomer
US5723609A (en) * 1988-03-30 1998-03-03 E. R. Squibb & Sons, Inc. Bis (hydroxymethyl) cyclobutyl purines
AU622926B2 (en) * 1988-09-09 1992-04-30 Nippon Kayaku Kabushiki Kaisha Pyrimidine or purine cyclobutane derivatives
IL92096A0 (en) * 1988-10-25 1990-07-12 Abbott Lab Carboxylic nucleoside analogs
US5064961A (en) * 1989-12-18 1991-11-12 E. R. Squibb & Sons, Inc. Process for preparing an optically active cyclobutane nucleoside

Also Published As

Publication number Publication date
GR3021125T3 (en) 1996-12-31
DE69211799D1 (de) 1996-08-01
DE69211799T2 (de) 1996-12-19
EP0535448B1 (en) 1996-06-26
ES2089327T3 (es) 1996-10-01
EP0535448A3 (en) 1993-10-13
EP0535448A2 (en) 1993-04-07
JPH05271232A (ja) 1993-10-19
ATE139762T1 (de) 1996-07-15
CA2079496A1 (en) 1993-04-03
US5185463A (en) 1993-02-09

Similar Documents

Publication Publication Date Title
ATE158798T1 (de) Verfahren zur herstellung von optisch aktiven zyklobutannukleosiden
DE69212011D1 (de) Endothelin Antagoniste
JPS5427520A (en) Purification of crude acrylic acid
GR3003748T3 (da)
DK0535448T3 (da) Fremgangsmåde og mellemprodukter til fremstilling af et antiviralt middel indeholdende en cyclobutylgruppe
DK0402322T3 (da) Fremgangsmåde til fremstilling af R(+)-aminocarnitin og S(-)-aminocarnitin
IT1164319B (it) Procedimento per la risoluzione dell'acido (+-)2-(6'-metossi-2'-naftil)-propionico
DE69211936T2 (de) Verfahren zur Herstellung von niedrigem Alkyl-2-oxo-L-Gulonat
DE3569725D1 (en) A method for the optical purification of an optically active 2,2-dimethylcyclopropanecarboxylic acid amide
KR960015807B1 (en) Process for the preparation of purified bis(2-hydrozyethyl) ester of 2,60naphthalenedi carboxylic acid
FR2665897B1 (fr) Procede de transformation de l'acide (benzoyl-3 phenyl)-2 propionique-r(-) en isomere s(+).
JPS56133244A (en) Optical resolution of (+-)-trans-chrysanthemum-mono- carboxylic acid
DK0551653T3 (da) Enantiomeric pure cis-2-oxa-5,8-diazabicyclo(4.3.0)nonanes and process for their preparation
ATE157655T1 (de) Verfahren zur herstellung von gegebenfalls 2- substituierten 5-chlorimidazolen
FR2653446B1 (fr) Procede d'obtention par fermentation d'acide citrique a partir d'hydrates de carbone.
JPS53116321A (en) Purification of organocyano compounds
JPS5297925A (en) Preparation of optically active p-hydroxyphenylglycine
JPS5416442A (en) Optical resolution of 3-pheoxymandelic acid
JPS5223037A (en) Process for preparation of optical active amino acid
JPS53108922A (en) Novel synthesis of opticallactive hydroxyacid
JPS5533440A (en) Optically active benzyl(2-hydroxymethylcyclohexyl) amine, its preparation, and its optical resolution
JPS53101302A (en) Purification of organocyamic compounds
JPS57145827A (en) Optical resolution of allethrolone
AU590659B2 (en) Process for producing l-amino acids or 5'-inosinic acid by fermentation
DK0473435T3 (da) Mono-N,N-dimethyl-4-aminopyridinium-sn-glycerol-3-phosphat, fremstilling og anvendelse deraf til fremstilling af phosphatidsyrer