DK0499837T3 - Defined Coating with Recombinant Fusion Proteins of Constant Fusion Partner and Variable Antigen Share in Diagnostic Test Systems - Google Patents

Defined Coating with Recombinant Fusion Proteins of Constant Fusion Partner and Variable Antigen Share in Diagnostic Test Systems

Info

Publication number
DK0499837T3
DK0499837T3 DK92101324.9T DK92101324T DK0499837T3 DK 0499837 T3 DK0499837 T3 DK 0499837T3 DK 92101324 T DK92101324 T DK 92101324T DK 0499837 T3 DK0499837 T3 DK 0499837T3
Authority
DK
Denmark
Prior art keywords
fusion proteins
constant
recombinant fusion
diagnostic test
test systems
Prior art date
Application number
DK92101324.9T
Other languages
Danish (da)
Inventor
Leszek Wieczorek
Hans-Peter Harthus
Udo Krupka
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Application granted granted Critical
Publication of DK0499837T3 publication Critical patent/DK0499837T3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to solid support materials, e.g. microtitre plates, beads or microbeads, magnetic particles, films, filter papers and the like, which are coated with antibodies against recombinant fusion proteins, and to processes for the reproducible and defined coating of these surfaces with such recombinant fusion proteins. The recombinant fusion proteins contain a constant fusion partner and a variable antigen portion which constitutes the specificity of the test system. The abovementioned antibodies are directed against the constant fusion partner, that is to say the part of each fusion protein which is intrinsically not of analytical interest and pure.
DK92101324.9T 1991-02-21 1992-01-28 Defined Coating with Recombinant Fusion Proteins of Constant Fusion Partner and Variable Antigen Share in Diagnostic Test Systems DK0499837T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4105400A DE4105400A1 (en) 1991-02-21 1991-02-21 DEFINED COATING WITH RECOMBINANT FUSION PROTEINS FROM CONSTANT FUSION PARTNER AND VARIABLE ANTIGEN IN DIAGNOSTIC TEST SYSTEMS

Publications (1)

Publication Number Publication Date
DK0499837T3 true DK0499837T3 (en) 1996-09-23

Family

ID=6425554

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92101324.9T DK0499837T3 (en) 1991-02-21 1992-01-28 Defined Coating with Recombinant Fusion Proteins of Constant Fusion Partner and Variable Antigen Share in Diagnostic Test Systems

Country Status (8)

Country Link
EP (1) EP0499837B1 (en)
JP (1) JP3370697B2 (en)
AT (1) ATE138202T1 (en)
AU (1) AU663481B2 (en)
CA (1) CA2061574A1 (en)
DE (2) DE4105400A1 (en)
DK (1) DK0499837T3 (en)
ES (1) ES2090373T3 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2580589C (en) 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
US8360321B2 (en) 2007-04-02 2013-01-29 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
JP2010530912A (en) 2007-06-22 2010-09-16 フィオ コーポレイション Manufacturing system and method for polymer microbeads doped with quantum dots
WO2009006739A1 (en) 2007-07-09 2009-01-15 Fio Corporation Systems and methods for enhancing fluorescent detection of target molecules in a test sample
CN101861203B (en) 2007-10-12 2014-01-22 Fio公司 Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto
WO2009155704A1 (en) 2008-06-25 2009-12-30 Fio Corporation Bio-threat alert system
BRPI0917839A2 (en) 2008-08-29 2015-11-24 Fio Corp single-use portable diagnostic test device, and associated system and method for testing environmental and biological test samples
CA2749660C (en) 2009-01-13 2017-10-31 Fio Corporation A handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3523701A1 (en) * 1985-07-03 1987-01-08 Bayer Ag PROCESS FOR PRODUCING PROTEINS AND POLYPEPTIDES
US4851341A (en) * 1986-12-19 1989-07-25 Immunex Corporation Immunoaffinity purification system
AU620330B2 (en) * 1987-05-29 1992-02-20 Smithkline Beckman Corporation Immunodiagnostic assays using chimeric antigens

Also Published As

Publication number Publication date
JPH06172400A (en) 1994-06-21
CA2061574A1 (en) 1992-08-22
DE4105400A1 (en) 1992-08-27
AU663481B2 (en) 1995-10-12
AU1107892A (en) 1992-08-27
DE59206261D1 (en) 1996-06-20
JP3370697B2 (en) 2003-01-27
EP0499837A1 (en) 1992-08-26
ATE138202T1 (en) 1996-06-15
ES2090373T3 (en) 1996-10-16
EP0499837B1 (en) 1996-05-15

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