AU1107892A - Defined coating with recombinant fusion proteins composed of constant fusion partner and variable antigen portion in diagnostic test systems - Google Patents

Defined coating with recombinant fusion proteins composed of constant fusion partner and variable antigen portion in diagnostic test systems

Info

Publication number
AU1107892A
AU1107892A AU11078/92A AU1107892A AU1107892A AU 1107892 A AU1107892 A AU 1107892A AU 11078/92 A AU11078/92 A AU 11078/92A AU 1107892 A AU1107892 A AU 1107892A AU 1107892 A AU1107892 A AU 1107892A
Authority
AU
Australia
Prior art keywords
fusion proteins
constant
recombinant fusion
diagnostic test
antigen portion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU11078/92A
Other versions
AU663481B2 (en
Inventor
Hans-Peter Harthus
Udo Krupka
Leszek Wieczorek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Dade Behring Marburg GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Marburg GmbH filed Critical Dade Behring Marburg GmbH
Publication of AU1107892A publication Critical patent/AU1107892A/en
Application granted granted Critical
Publication of AU663481B2 publication Critical patent/AU663481B2/en
Assigned to DADE BEHRING MARBURG GMBH reassignment DADE BEHRING MARBURG GMBH Request to Amend Deed and Register Assignors: BEHRINGWERKE AKTIENGESELLSCHAFT
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to solid support materials, e.g. microtitre plates, beads or microbeads, magnetic particles, films, filter papers and the like, which are coated with antibodies against recombinant fusion proteins, and to processes for the reproducible and defined coating of these surfaces with such recombinant fusion proteins. The recombinant fusion proteins contain a constant fusion partner and a variable antigen portion which constitutes the specificity of the test system. The abovementioned antibodies are directed against the constant fusion partner, that is to say the part of each fusion protein which is intrinsically not of analytical interest and pure.
AU11078/92A 1991-02-21 1992-02-20 Defined coating with recombinant fusion proteins composed of constant fusion partner and variable antigen portion in diagnostic test systems Ceased AU663481B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4105400A DE4105400A1 (en) 1991-02-21 1991-02-21 DEFINED COATING WITH RECOMBINANT FUSION PROTEINS FROM CONSTANT FUSION PARTNER AND VARIABLE ANTIGEN IN DIAGNOSTIC TEST SYSTEMS
DE4105400 1991-02-21

Publications (2)

Publication Number Publication Date
AU1107892A true AU1107892A (en) 1992-08-27
AU663481B2 AU663481B2 (en) 1995-10-12

Family

ID=6425554

Family Applications (1)

Application Number Title Priority Date Filing Date
AU11078/92A Ceased AU663481B2 (en) 1991-02-21 1992-02-20 Defined coating with recombinant fusion proteins composed of constant fusion partner and variable antigen portion in diagnostic test systems

Country Status (8)

Country Link
EP (1) EP0499837B1 (en)
JP (1) JP3370697B2 (en)
AT (1) ATE138202T1 (en)
AU (1) AU663481B2 (en)
CA (1) CA2061574A1 (en)
DE (2) DE4105400A1 (en)
DK (1) DK0499837T3 (en)
ES (1) ES2090373T3 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2580589C (en) 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
CA2682826C (en) 2007-04-02 2013-08-13 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
CA2692259C (en) 2007-06-22 2012-07-31 Fio Corporation Systems and methods for manufacturing quantum dot-doped polymer microbeads
CA2693055C (en) 2007-07-09 2012-02-21 Fio Corporation Systems and methods for enhancing fluorescent detection of target molecules in a test sample
US8551763B2 (en) 2007-10-12 2013-10-08 Fio Corporation Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto
WO2009155704A1 (en) 2008-06-25 2009-12-30 Fio Corporation Bio-threat alert system
RU2515209C2 (en) 2008-08-29 2014-05-10 Эф-Ай-Оу Корпорейшн Disposable portable diagnostic instrument and appropriate system and method to investigate biological and natural samples
WO2010081219A1 (en) 2009-01-13 2010-07-22 Fio Corporation A handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3523701A1 (en) * 1985-07-03 1987-01-08 Bayer Ag PROCESS FOR PRODUCING PROTEINS AND POLYPEPTIDES
US4851341A (en) * 1986-12-19 1989-07-25 Immunex Corporation Immunoaffinity purification system
AU620330B2 (en) * 1987-05-29 1992-02-20 Smithkline Beckman Corporation Immunodiagnostic assays using chimeric antigens

Also Published As

Publication number Publication date
JP3370697B2 (en) 2003-01-27
ATE138202T1 (en) 1996-06-15
EP0499837A1 (en) 1992-08-26
DE59206261D1 (en) 1996-06-20
CA2061574A1 (en) 1992-08-22
ES2090373T3 (en) 1996-10-16
DE4105400A1 (en) 1992-08-27
DK0499837T3 (en) 1996-09-23
EP0499837B1 (en) 1996-05-15
JPH06172400A (en) 1994-06-21
AU663481B2 (en) 1995-10-12

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired