DK0485479T3 - Perfluor-t-butylholdige forbindelser til anvendelse ved fluor-19 NMR og/eller MRI - Google Patents

Perfluor-t-butylholdige forbindelser til anvendelse ved fluor-19 NMR og/eller MRI

Info

Publication number
DK0485479T3
DK0485479T3 DK90912277.2T DK90912277T DK0485479T3 DK 0485479 T3 DK0485479 T3 DK 0485479T3 DK 90912277 T DK90912277 T DK 90912277T DK 0485479 T3 DK0485479 T3 DK 0485479T3
Authority
DK
Denmark
Prior art keywords
moiety
mri
perfluoro
nmr
butyl
Prior art date
Application number
DK90912277.2T
Other languages
Danish (da)
English (en)
Inventor
Walter John Rogers Jr
Thomas Stephen Everett
Original Assignee
Univ Johns Hopkins
Univ State Towson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, Univ State Towson filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of DK0485479T3 publication Critical patent/DK0485479T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
DK90912277.2T 1989-07-31 1990-07-19 Perfluor-t-butylholdige forbindelser til anvendelse ved fluor-19 NMR og/eller MRI DK0485479T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/388,049 US5116599A (en) 1989-07-31 1989-07-31 Perfluoro-t-butyl-containing compounds for use in fluorine-19 nmr and/or mri

Publications (1)

Publication Number Publication Date
DK0485479T3 true DK0485479T3 (da) 1996-05-13

Family

ID=23532431

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90912277.2T DK0485479T3 (da) 1989-07-31 1990-07-19 Perfluor-t-butylholdige forbindelser til anvendelse ved fluor-19 NMR og/eller MRI

Country Status (10)

Country Link
US (3) US5116599A (de)
EP (1) EP0485479B1 (de)
JP (1) JPH05501869A (de)
AT (1) ATE136223T1 (de)
AU (1) AU651559B2 (de)
CA (1) CA2064567A1 (de)
DE (1) DE69026384T2 (de)
DK (1) DK0485479T3 (de)
ES (1) ES2087161T3 (de)
WO (1) WO1991001759A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5236694A (en) * 1990-02-21 1993-08-17 The Board Of Regents, The University Of Texas System 19f labelled dextrans and antibodies as nmr imaging and spectroscopy agents
US5250283A (en) * 1990-03-28 1993-10-05 Molecular Biosystems, Inc. Organic contrast agent analog and method of making same
US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
US5318770A (en) * 1991-10-25 1994-06-07 Mallinckrodt Medical, Inc. Trifluoromethyl analogs of X-ray contrast media for magnetic resonance imaging
US5362477A (en) * 1991-10-25 1994-11-08 Mallinckrodt Medical, Inc. 19F magnetic resonance imaging agents which include a nitroxide moiety
US5403575A (en) * 1991-12-12 1995-04-04 Hemagen/Pfc Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them
GB9216843D0 (en) * 1992-08-07 1992-09-23 Cancer Res Inst Contrast agents for medical imaging
US5420359A (en) * 1992-12-11 1995-05-30 Minnesota Mining And Manufacturing Company Chlorofluoroether compositions and preparation thereof
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US20030133955A1 (en) * 1993-02-22 2003-07-17 American Bioscience, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5665382A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US20030068362A1 (en) * 1993-02-22 2003-04-10 American Bioscience, Inc. Methods and formulations for the delivery of pharmacologically active agents
US5401493A (en) * 1993-03-26 1995-03-28 Molecular Biosystems, Inc. Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same
US6645463B1 (en) 1994-05-16 2003-11-11 The Board Of Regents Of The University Of Michigan Blood-pool selective carrier for lipophilic imaging agents
US5851510A (en) * 1994-05-16 1998-12-22 The Board Of Regents Of The University Of Michigan Hepatocyte-selective oil-in-water emulsion
US5622687A (en) * 1994-11-15 1997-04-22 Molecular Biosystems, Inc. Calixarene conjugates useful as MRI and CT diagnostic imaging agents
US5660815A (en) * 1995-04-28 1997-08-26 Molecular Biosystems, Inc. Water soluble fluorinated fatty acid sulfonate derivatives useful as magnetic resonance imaging agents
FR2736051B3 (fr) * 1995-06-29 1997-09-26 Guerbet Sa Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique
US5808146A (en) * 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
DE19719280C1 (de) 1997-05-07 1998-09-24 Pharm Pur Gmbh Fluorierte Alkane und ihre Verwendungen
AU7702798A (en) * 1997-05-30 1998-12-30 Alliance Pharmaceutical Corporation Methods and apparatus for monitoring and quantifying the movement of fluid
US6907280B2 (en) * 1999-12-02 2005-06-14 The General Hospital Corporation Method and apparatus for objectively measuring pain, pain treatment and other related techniques
AU1943301A (en) * 1999-12-02 2001-06-12 General Hospital Corporation, The Method and apparatus for measuring indices of brain activity
US6574497B1 (en) 2000-12-22 2003-06-03 Advanced Cardiovascular Systems, Inc. MRI medical device markers utilizing fluorine-19
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
US20080220075A1 (en) * 2002-03-20 2008-09-11 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
CA2479665C (en) * 2002-03-20 2011-08-30 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
US7030208B2 (en) * 2002-04-11 2006-04-18 Carbomer, Inc. Biocompatible materials and probes
WO2003093412A2 (en) * 2002-04-30 2003-11-13 Emory University Tumor imaging compounds
WO2006059252A2 (en) * 2004-11-12 2006-06-08 Neurochem (International) Limited Methods and fluorinated compositions for treating amyloid-related diseases
TWI265916B (en) * 2004-12-31 2006-11-11 Ind Tech Res Inst Process of making YAG fluorescence powder
EP1846042A2 (de) * 2005-01-05 2007-10-24 Board of Regents, The University of Texas System Konjugate zur doppelten abbildung und radiochemotherapie: zusammensetzung sowie herstellung und anwendungen davon
WO2006096499A2 (en) * 2005-03-04 2006-09-14 Washington University Mr coronary angiography with a fluorinated nanoparticle contrast agent at 1.5 t
EP1893246A4 (de) * 2005-06-23 2009-05-06 Univ Emory Stereoselektive synthese von aminosäureanaloga für tumorbildgebung
CA2612186A1 (en) 2005-06-23 2007-01-04 Emory University Imaging agents
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
CN112679533B (zh) * 2020-12-25 2021-09-14 中国科学院兰州化学物理研究所 一种含氟探针及其制备方法与应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3911138B1 (en) * 1973-02-26 1996-10-29 Childrens Hosp Medical Center Artificial blood and method for supporting oxygen transport in animals
GB1513135A (en) * 1974-06-04 1978-06-07 Res Inst For Med & Chem Inc Fluorination process and fluoro steroids
US4105798A (en) * 1976-07-19 1978-08-08 Sun Ventures, Inc. Perfluoro polycyclic compounds for use as synthetic blood and perfusion media
US4173654A (en) * 1977-01-03 1979-11-06 California Institute Of Technology Novel fluorohydrocarbons
US4110474A (en) * 1977-08-26 1978-08-29 Suntech, Inc. Tetramethylpentane blood substitutes
US4187252A (en) * 1977-08-26 1980-02-05 Suntech, Inc. Tetramethylpentane blood substitutes
US4523039A (en) * 1980-04-11 1985-06-11 The University Of Texas Method for forming perfluorocarbon ethers
CA1181011A (en) * 1980-05-27 1985-01-15 Robert P. Geyer Perfluorinated n,n-dimethyl cyclohexylmethylamine and emulsions containing the same
US4395393A (en) * 1981-08-10 1983-07-26 Basf Wyandotte Corporation Artificial blood emulsifiers
US4453028A (en) * 1982-03-29 1984-06-05 Lagow Richard J Perfluorinated compounds with cyclohexyl groups
US4443480A (en) * 1982-04-12 1984-04-17 Children's Hospital Medical Center Artificial blood and other gas transport agents
US4640833A (en) * 1983-02-28 1987-02-03 Adamantech, Inc. Use of perfluorobromoalkyl ethers as X-ray contrast agents
US4586511A (en) * 1983-03-04 1986-05-06 Children's Hospital Medical Center Methods and compositions for detecting and imaging a gas in an animal by nuclear magnetic resonance
US4775522A (en) * 1983-03-04 1988-10-04 Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center NMR compositions for indirectly detecting a dissolved gas in an animal
US4558279A (en) * 1983-03-07 1985-12-10 University Of Cincinnati Methods for detecting and imaging a temperature of an object by nuclear magnetic resonance
US4612185A (en) * 1984-10-15 1986-09-16 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
US4820505A (en) * 1985-04-04 1989-04-11 Scripps Clinic And Research Foundation Detection of activated platelets with antibodies to thrombospondin
US4865836A (en) * 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
FR2595770B1 (fr) * 1986-03-13 1989-12-08 Brev Ind Marine Exploit Dispositif d'alimentation en fluide d'une installation hydraulique, pneumatique ou hydro-pneumatique

Also Published As

Publication number Publication date
EP0485479A1 (de) 1992-05-20
AU6164590A (en) 1991-03-11
US5324504A (en) 1994-06-28
DE69026384T2 (de) 1996-08-08
AU651559B2 (en) 1994-07-28
US5397563A (en) 1995-03-14
JPH05501869A (ja) 1993-04-08
WO1991001759A1 (en) 1991-02-21
ATE136223T1 (de) 1996-04-15
EP0485479B1 (de) 1996-04-03
ES2087161T3 (es) 1996-07-16
DE69026384D1 (de) 1996-05-09
CA2064567A1 (en) 1991-02-01
US5116599A (en) 1992-05-26

Similar Documents

Publication Publication Date Title
DK0485479T3 (da) Perfluor-t-butylholdige forbindelser til anvendelse ved fluor-19 NMR og/eller MRI
Weisskoff Simple measurement of scanner stability for functional NMR imaging of activation in the brain
GB0014463D0 (en) NMR Method
AU2003273242A1 (en) Microvascular blood volume magnetic resonance imaging
GB2175401A (en) Gyromagnetic resonance spectroscopy
IL109115A (en) Methods for measurement of nmr-detectable xenobiotic compounds
US6069478A (en) Magnetic resonance spectroscopic imaging having reduced parasitic side band signals
Kaartinen et al. Automated Quantification of Human Brain Metabolites by Artificial Neural Network Analysis from in Vivo Single-Voxel^ 1H NMR Spectra
Brown et al. Analysis of human aqueous humour by high resolution 1H NMR spectroscopy
Jahnke et al. Enhanced sensitivity of rapidly exchanging amide protons by improved phase cycling and the constructive use of radiation damping
Liu et al. Recovery of underwater resonances by magnetization transferred NMR spectroscopy (RECUR-NMR)
Ghosh et al. Mouse lemur microscopic MRI brain atlas
Maschke et al. Diagnosis of a case of acute chloroquine poisoning using 1H NMR spectroscopy: characterisation of drug metabolites in urine
US6781372B2 (en) Imaging process in the spatial frequency space and useful for examining the properties of object
Kim Prominence magnetic field observations
Yildirim et al. Chemical shift independent imaging of 19F contrast agents using ultrafast MRSI (F-uTSI)
Granot 5117187 Localized multi-region magnetic resonance data acquisition
Burum et al. 5117186 Method for increasing resolution in two-dimensional solid-state NMR heteronuclear correlation spectra
Ohkawa 5117188 Quasi-open magnet configuration for use in magnetic resonance imaging
US6342786B1 (en) Magnetic resonance tomography apparatus and method in the form of a frequency-selective and location-selective RF pulse sequence for operating same
CN108680884B (zh) 一种实现单体素定域二维相敏j分解谱方法
Rogers et al. 5234680 Perfluoro-T-butyl containing compounds for use in fluorine-19 NMR and/or MRI
Holt et al. 5233992 MRI method for high liver iron measurement using magnetic susceptibility induced field distortions
Opella et al. 19F longitudinal relaxation rates from dynamic negative nuclear overhauser effects
CA2113558A1 (en) Detection of Explosive and Narcotics by Low Power Large Sample Volume Nuclear Quadrupole Resonance (NQR)