DK0485479T3 - Perfluor-t-butylholdige forbindelser til anvendelse ved fluor-19 NMR og/eller MRI - Google Patents
Perfluor-t-butylholdige forbindelser til anvendelse ved fluor-19 NMR og/eller MRIInfo
- Publication number
- DK0485479T3 DK0485479T3 DK90912277.2T DK90912277T DK0485479T3 DK 0485479 T3 DK0485479 T3 DK 0485479T3 DK 90912277 T DK90912277 T DK 90912277T DK 0485479 T3 DK0485479 T3 DK 0485479T3
- Authority
- DK
- Denmark
- Prior art keywords
- moiety
- mri
- perfluoro
- nmr
- butyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/388,049 US5116599A (en) | 1989-07-31 | 1989-07-31 | Perfluoro-t-butyl-containing compounds for use in fluorine-19 nmr and/or mri |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0485479T3 true DK0485479T3 (da) | 1996-05-13 |
Family
ID=23532431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90912277.2T DK0485479T3 (da) | 1989-07-31 | 1990-07-19 | Perfluor-t-butylholdige forbindelser til anvendelse ved fluor-19 NMR og/eller MRI |
Country Status (10)
Country | Link |
---|---|
US (3) | US5116599A (de) |
EP (1) | EP0485479B1 (de) |
JP (1) | JPH05501869A (de) |
AT (1) | ATE136223T1 (de) |
AU (1) | AU651559B2 (de) |
CA (1) | CA2064567A1 (de) |
DE (1) | DE69026384T2 (de) |
DK (1) | DK0485479T3 (de) |
ES (1) | ES2087161T3 (de) |
WO (1) | WO1991001759A1 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5236694A (en) * | 1990-02-21 | 1993-08-17 | The Board Of Regents, The University Of Texas System | 19f labelled dextrans and antibodies as nmr imaging and spectroscopy agents |
US5250283A (en) * | 1990-03-28 | 1993-10-05 | Molecular Biosystems, Inc. | Organic contrast agent analog and method of making same |
US5368840A (en) * | 1990-04-10 | 1994-11-29 | Imarx Pharmaceutical Corp. | Natural polymers as contrast media for magnetic resonance imaging |
US5362477A (en) * | 1991-10-25 | 1994-11-08 | Mallinckrodt Medical, Inc. | 19F magnetic resonance imaging agents which include a nitroxide moiety |
US5318770A (en) * | 1991-10-25 | 1994-06-07 | Mallinckrodt Medical, Inc. | Trifluoromethyl analogs of X-ray contrast media for magnetic resonance imaging |
US5403575A (en) * | 1991-12-12 | 1995-04-04 | Hemagen/Pfc | Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them |
GB9216843D0 (en) * | 1992-08-07 | 1992-09-23 | Cancer Res Inst | Contrast agents for medical imaging |
US5420359A (en) * | 1992-12-11 | 1995-05-30 | Minnesota Mining And Manufacturing Company | Chlorofluoroether compositions and preparation thereof |
US20030068362A1 (en) * | 1993-02-22 | 2003-04-10 | American Bioscience, Inc. | Methods and formulations for the delivery of pharmacologically active agents |
US20030133955A1 (en) * | 1993-02-22 | 2003-07-17 | American Bioscience, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
US5650156A (en) * | 1993-02-22 | 1997-07-22 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of nutriceuticals and compositions useful therefor |
US6753006B1 (en) | 1993-02-22 | 2004-06-22 | American Bioscience, Inc. | Paclitaxel-containing formulations |
US5362478A (en) * | 1993-03-26 | 1994-11-08 | Vivorx Pharmaceuticals, Inc. | Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell |
US5665382A (en) * | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of pharmaceutically active agents for in vivo delivery |
US5401493A (en) * | 1993-03-26 | 1995-03-28 | Molecular Biosystems, Inc. | Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same |
US6645463B1 (en) | 1994-05-16 | 2003-11-11 | The Board Of Regents Of The University Of Michigan | Blood-pool selective carrier for lipophilic imaging agents |
US5851510A (en) * | 1994-05-16 | 1998-12-22 | The Board Of Regents Of The University Of Michigan | Hepatocyte-selective oil-in-water emulsion |
WO1998053855A1 (en) * | 1997-05-30 | 1998-12-03 | Alliance Pharmaceutical Corp. | Methods and apparatus for monitoring and quantifying the movement of fluid |
US5622687A (en) * | 1994-11-15 | 1997-04-22 | Molecular Biosystems, Inc. | Calixarene conjugates useful as MRI and CT diagnostic imaging agents |
US5660815A (en) * | 1995-04-28 | 1997-08-26 | Molecular Biosystems, Inc. | Water soluble fluorinated fatty acid sulfonate derivatives useful as magnetic resonance imaging agents |
FR2736051B3 (fr) * | 1995-06-29 | 1997-09-26 | Guerbet Sa | Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique |
US5808146A (en) * | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
DE19719280C1 (de) * | 1997-05-07 | 1998-09-24 | Pharm Pur Gmbh | Fluorierte Alkane und ihre Verwendungen |
US6907280B2 (en) * | 1999-12-02 | 2005-06-14 | The General Hospital Corporation | Method and apparatus for objectively measuring pain, pain treatment and other related techniques |
WO2001039664A1 (en) * | 1999-12-02 | 2001-06-07 | The General Hospital Corporation | Method and apparatus for measuring indices of brain activity |
US20040033267A1 (en) * | 2002-03-20 | 2004-02-19 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
US6574497B1 (en) | 2000-12-22 | 2003-06-03 | Advanced Cardiovascular Systems, Inc. | MRI medical device markers utilizing fluorine-19 |
US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
US20080220075A1 (en) * | 2002-03-20 | 2008-09-11 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
JP2005531648A (ja) * | 2002-04-11 | 2005-10-20 | カルボマー インク | 生体適合性物質およびプローブ類 |
EP1499584B1 (de) * | 2002-04-30 | 2010-08-18 | Emory University | Verbindungen zur abbildung von tumoren |
US20060183800A1 (en) * | 2004-11-12 | 2006-08-17 | Xianqi Kong | Methods and fluorinated compositions for treating amyloid-related diseases |
TWI265916B (en) * | 2004-12-31 | 2006-11-11 | Ind Tech Res Inst | Process of making YAG fluorescence powder |
JP2008531755A (ja) * | 2005-01-05 | 2008-08-14 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム | 二重画像化および放射線化学療法のためのコンジュゲート:組成物、製造および適応 |
WO2006096499A2 (en) * | 2005-03-04 | 2006-09-14 | Washington University | Mr coronary angiography with a fluorinated nanoparticle contrast agent at 1.5 t |
EP1893244A4 (de) | 2005-06-23 | 2009-06-24 | Univ Emory | Kontrastmittel |
US20060292073A1 (en) * | 2005-06-23 | 2006-12-28 | Emory University | Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging |
US8246752B2 (en) | 2008-01-25 | 2012-08-21 | Clear Catheter Systems, Inc. | Methods and devices to clear obstructions from medical tubes |
CN112679533B (zh) * | 2020-12-25 | 2021-09-14 | 中国科学院兰州化学物理研究所 | 一种含氟探针及其制备方法与应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3911138B1 (en) * | 1973-02-26 | 1996-10-29 | Childrens Hosp Medical Center | Artificial blood and method for supporting oxygen transport in animals |
GB1513135A (en) * | 1974-06-04 | 1978-06-07 | Res Inst For Med & Chem Inc | Fluorination process and fluoro steroids |
US4105798A (en) * | 1976-07-19 | 1978-08-08 | Sun Ventures, Inc. | Perfluoro polycyclic compounds for use as synthetic blood and perfusion media |
US4173654A (en) * | 1977-01-03 | 1979-11-06 | California Institute Of Technology | Novel fluorohydrocarbons |
US4110474A (en) * | 1977-08-26 | 1978-08-29 | Suntech, Inc. | Tetramethylpentane blood substitutes |
US4187252A (en) * | 1977-08-26 | 1980-02-05 | Suntech, Inc. | Tetramethylpentane blood substitutes |
US4523039A (en) * | 1980-04-11 | 1985-06-11 | The University Of Texas | Method for forming perfluorocarbon ethers |
CA1181011A (en) * | 1980-05-27 | 1985-01-15 | Robert P. Geyer | Perfluorinated n,n-dimethyl cyclohexylmethylamine and emulsions containing the same |
US4395393A (en) * | 1981-08-10 | 1983-07-26 | Basf Wyandotte Corporation | Artificial blood emulsifiers |
US4453028A (en) * | 1982-03-29 | 1984-06-05 | Lagow Richard J | Perfluorinated compounds with cyclohexyl groups |
US4443480A (en) * | 1982-04-12 | 1984-04-17 | Children's Hospital Medical Center | Artificial blood and other gas transport agents |
US4640833A (en) * | 1983-02-28 | 1987-02-03 | Adamantech, Inc. | Use of perfluorobromoalkyl ethers as X-ray contrast agents |
US4586511A (en) * | 1983-03-04 | 1986-05-06 | Children's Hospital Medical Center | Methods and compositions for detecting and imaging a gas in an animal by nuclear magnetic resonance |
US4775522A (en) * | 1983-03-04 | 1988-10-04 | Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center | NMR compositions for indirectly detecting a dissolved gas in an animal |
US4558279A (en) * | 1983-03-07 | 1985-12-10 | University Of Cincinnati | Methods for detecting and imaging a temperature of an object by nuclear magnetic resonance |
US4612185A (en) * | 1984-10-15 | 1986-09-16 | Mallinckrodt, Inc. | Methods and compositions for enhancing magnetic resonance imaging |
US4820505A (en) * | 1985-04-04 | 1989-04-11 | Scripps Clinic And Research Foundation | Detection of activated platelets with antibodies to thrombospondin |
US4865836A (en) * | 1986-01-14 | 1989-09-12 | Fluoromed Pharmaceutical, Inc. | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport |
FR2595770B1 (fr) * | 1986-03-13 | 1989-12-08 | Brev Ind Marine Exploit | Dispositif d'alimentation en fluide d'une installation hydraulique, pneumatique ou hydro-pneumatique |
-
1989
- 1989-07-31 US US07/388,049 patent/US5116599A/en not_active Expired - Lifetime
-
1990
- 1990-07-19 DK DK90912277.2T patent/DK0485479T3/da active
- 1990-07-19 CA CA002064567A patent/CA2064567A1/en not_active Abandoned
- 1990-07-19 ES ES90912277T patent/ES2087161T3/es not_active Expired - Lifetime
- 1990-07-19 DE DE69026384T patent/DE69026384T2/de not_active Expired - Fee Related
- 1990-07-19 EP EP90912277A patent/EP0485479B1/de not_active Expired - Lifetime
- 1990-07-19 AT AT90912277T patent/ATE136223T1/de not_active IP Right Cessation
- 1990-07-19 WO PCT/US1990/003961 patent/WO1991001759A1/en active IP Right Grant
- 1990-07-19 JP JP2511521A patent/JPH05501869A/ja active Pending
- 1990-07-19 AU AU61645/90A patent/AU651559B2/en not_active Ceased
-
1993
- 1993-03-04 US US08/010,013 patent/US5324504A/en not_active Expired - Lifetime
-
1994
- 1994-03-01 US US08/203,945 patent/US5397563A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1991001759A1 (en) | 1991-02-21 |
US5397563A (en) | 1995-03-14 |
ATE136223T1 (de) | 1996-04-15 |
US5324504A (en) | 1994-06-28 |
ES2087161T3 (es) | 1996-07-16 |
EP0485479A1 (de) | 1992-05-20 |
DE69026384T2 (de) | 1996-08-08 |
US5116599A (en) | 1992-05-26 |
CA2064567A1 (en) | 1991-02-01 |
EP0485479B1 (de) | 1996-04-03 |
AU6164590A (en) | 1991-03-11 |
DE69026384D1 (de) | 1996-05-09 |
AU651559B2 (en) | 1994-07-28 |
JPH05501869A (ja) | 1993-04-08 |
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