DK0463139T3 - 2,13-disubstituted ergolines, their preparation and their use in pharmaceuticals - Google Patents

2,13-disubstituted ergolines, their preparation and their use in pharmaceuticals

Info

Publication number
DK0463139T3
DK0463139T3 DK91902179.0T DK91902179T DK0463139T3 DK 0463139 T3 DK0463139 T3 DK 0463139T3 DK 91902179 T DK91902179 T DK 91902179T DK 0463139 T3 DK0463139 T3 DK 0463139T3
Authority
DK
Denmark
Prior art keywords
pharmaceuticals
preparation
ergolines
disubstituted
disubstituted ergolines
Prior art date
Application number
DK91902179.0T
Other languages
Danish (da)
Inventor
Thomas Brumby
Helmut Wachtel
Gerhard Sauer
Bernd Schroeter
Peter-Andreas Loeschmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0463139T3 publication Critical patent/DK0463139T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Described are compounds of the formula (I) and their acid addition salts, in which R?2, R?6, R?13 and X have the meaning given in the application, plus a method of preparing the compounds and drugs containing them.
DK91902179.0T 1990-01-15 1991-01-15 2,13-disubstituted ergolines, their preparation and their use in pharmaceuticals DK0463139T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4001323A DE4001323A1 (en) 1990-01-15 1990-01-15 2,13-DISUBSTITUTED ERGOLINE, THEIR PRODUCTION AND USE IN MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
DK0463139T3 true DK0463139T3 (en) 1995-11-06

Family

ID=6398304

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91902179.0T DK0463139T3 (en) 1990-01-15 1991-01-15 2,13-disubstituted ergolines, their preparation and their use in pharmaceuticals

Country Status (10)

Country Link
EP (1) EP0463139B1 (en)
JP (1) JPH04504425A (en)
AT (1) ATE124945T1 (en)
CA (1) CA2049016A1 (en)
CZ (1) CZ279777B6 (en)
DE (2) DE4001323A1 (en)
DK (1) DK0463139T3 (en)
ES (1) ES2076517T3 (en)
HU (1) HUT58093A (en)
WO (1) WO1991010663A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0160842B1 (en) * 1984-04-09 1994-06-22 Schering Aktiengesellschaft 2-Substituted ergoline derivatives, processes for their preparation, and their use as medicaments
DE3533675A1 (en) * 1985-09-19 1987-03-26 Schering Ag NEW 12- AND 13-BROMINE ERGOL DERIVATIVES
DE3533672A1 (en) * 1985-09-19 1987-03-26 Schering Ag NEW 12- AND 13-SUBSTITUTED ERGOL DERIVATIVES
DE3806374A1 (en) * 1988-02-25 1989-09-07 Schering Ag NEW ERGOLIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
JPH04504425A (en) 1992-08-06
CZ279777B6 (en) 1995-06-14
EP0463139B1 (en) 1995-07-12
ATE124945T1 (en) 1995-07-15
HUT58093A (en) 1992-01-28
CS9100077A2 (en) 1991-10-15
CA2049016A1 (en) 1991-07-16
DE59105961D1 (en) 1995-08-17
WO1991010663A1 (en) 1991-07-25
EP0463139A1 (en) 1992-01-02
ES2076517T3 (en) 1995-11-01
DE4001323A1 (en) 1991-07-18

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