CS9100077A2 - 2,13-d-disubstituted ergolines and method of their production - Google Patents

2,13-d-disubstituted ergolines and method of their production

Info

Publication number
CS9100077A2
CS9100077A2 CS9177A CS7791A CS9100077A2 CS 9100077 A2 CS9100077 A2 CS 9100077A2 CS 9177 A CS9177 A CS 9177A CS 7791 A CS7791 A CS 7791A CS 9100077 A2 CS9100077 A2 CS 9100077A2
Authority
CS
Czechoslovakia
Prior art keywords
production
ergolines
disubstituted
disubstituted ergolines
compounds
Prior art date
Application number
CS9177A
Other languages
Czech (cs)
Inventor
Gerhard Dr Sauer
Bernd Dr Schroter
Thomas Dr Brumby
Helmut Dr Wachtel
Peter Andreas H Loschmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CS9100077A2 publication Critical patent/CS9100077A2/en
Publication of CZ279777B6 publication Critical patent/CZ279777B6/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Described are compounds of the formula (I) and their acid addition salts, in which R?2, R?6, R?13 and X have the meaning given in the application, plus a method of preparing the compounds and drugs containing them.
CS9177A 1990-01-15 1991-01-15 2,13-d-disubstituted ergolines, process of their preparation and their use for preparation of medicaments CZ279777B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4001323A DE4001323A1 (en) 1990-01-15 1990-01-15 2,13-DISUBSTITUTED ERGOLINE, THEIR PRODUCTION AND USE IN MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
CS9100077A2 true CS9100077A2 (en) 1991-10-15
CZ279777B6 CZ279777B6 (en) 1995-06-14

Family

ID=6398304

Country Status (10)

Country Link
EP (1) EP0463139B1 (en)
JP (1) JPH04504425A (en)
AT (1) ATE124945T1 (en)
CA (1) CA2049016A1 (en)
CZ (1) CZ279777B6 (en)
DE (2) DE4001323A1 (en)
DK (1) DK0463139T3 (en)
ES (1) ES2076517T3 (en)
HU (1) HUT58093A (en)
WO (1) WO1991010663A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3587860D1 (en) * 1984-04-09 1994-07-28 Schering Ag 2-Substituted ergoline derivatives, process for their preparation and their use as medicines.
DE3533672A1 (en) * 1985-09-19 1987-03-26 Schering Ag NEW 12- AND 13-SUBSTITUTED ERGOL DERIVATIVES
DE3533675A1 (en) * 1985-09-19 1987-03-26 Schering Ag NEW 12- AND 13-BROMINE ERGOL DERIVATIVES
DE3806374A1 (en) * 1988-02-25 1989-09-07 Schering Ag NEW ERGOLIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
EP0463139B1 (en) 1995-07-12
EP0463139A1 (en) 1992-01-02
ES2076517T3 (en) 1995-11-01
DE4001323A1 (en) 1991-07-18
CA2049016A1 (en) 1991-07-16
CZ279777B6 (en) 1995-06-14
DK0463139T3 (en) 1995-11-06
HUT58093A (en) 1992-01-28
ATE124945T1 (en) 1995-07-15
DE59105961D1 (en) 1995-08-17
JPH04504425A (en) 1992-08-06
WO1991010663A1 (en) 1991-07-25

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