DK0409936T3 - Process for Preparation of Aqueous Mixture Cell Solutions - Google Patents

Process for Preparation of Aqueous Mixture Cell Solutions

Info

Publication number
DK0409936T3
DK0409936T3 DK90901552.1T DK90901552T DK0409936T3 DK 0409936 T3 DK0409936 T3 DK 0409936T3 DK 90901552 T DK90901552 T DK 90901552T DK 0409936 T3 DK0409936 T3 DK 0409936T3
Authority
DK
Denmark
Prior art keywords
active substances
lipoids
temperature
water
preparation
Prior art date
Application number
DK90901552.1T
Other languages
Danish (da)
Inventor
Johannes-Wilhelm Tack
Heinrich Michel
Detlef Goeritz
Georg Roessling
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0409936T3 publication Critical patent/DK0409936T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Colloid Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Mushroom Cultivation (AREA)

Abstract

A process for producing aqueous mixed micelle solutions containing mixed micelles formed from lipoids and salts of bile acids, in which, if desired, active substances hardly soluble or insoluble in water are solubilized, is characterized in that the free bile acids are suspended in an aqueous solution possibly containing isotonizing additives and/or water-soluble active substances at a temperature of 40C to 100C, the lipoids are dispersed in this suspension at a temperature of 40C to 100C and the dispersion obtained is neutralized with bases at a temperature of 0C to 100C, provided that, if necessary, the active substances which are hardly soluble or insoluble in water are dispersed together with the lipoids or solubilized in the mixed micelle solution which does not contain these active substances.
DK90901552.1T 1989-02-06 1990-01-16 Process for Preparation of Aqueous Mixture Cell Solutions DK0409936T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3903753A DE3903753A1 (en) 1989-02-06 1989-02-06 METHOD FOR PRODUCING AQUEOUS MIXED MICRO SOLUTIONS

Publications (1)

Publication Number Publication Date
DK0409936T3 true DK0409936T3 (en) 1994-07-18

Family

ID=6373663

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90901552.1T DK0409936T3 (en) 1989-02-06 1990-01-16 Process for Preparation of Aqueous Mixture Cell Solutions

Country Status (15)

Country Link
EP (1) EP0409936B1 (en)
JP (1) JPH03503899A (en)
AT (1) ATE103803T1 (en)
AU (1) AU636327B2 (en)
CA (1) CA2009307A1 (en)
DD (1) DD291696A5 (en)
DE (2) DE3903753A1 (en)
DK (1) DK0409936T3 (en)
ES (1) ES2052246T3 (en)
FI (1) FI904892A0 (en)
GR (1) GR900100034A (en)
HU (1) HU206260B (en)
IE (1) IE65555B1 (en)
PT (1) PT93055B (en)
WO (1) WO1990008534A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2033725C (en) * 1990-01-24 2001-05-29 Folker Pittrof Pharmaceutical and cosmetic compositions containing a salt of cholanic acid
EP0471309A1 (en) * 1990-08-17 1992-02-19 F. Hoffmann-La Roche Ag Use of mixed micelles
DE4120109A1 (en) * 1991-06-15 1992-12-17 Schering Ag 3-ARYL OR 3-HETARYL (BETA) CARBOLINES, THEIR PRODUCTION AND USE IN MEDICINAL PRODUCTS
JP2740153B2 (en) * 1995-03-07 1998-04-15 エフ・ホフマン−ラ ロシユ アーゲー Mixed micelle

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1202370B (en) * 1976-07-12 1989-02-09 Hoffmann La Roche INJECTABLE SOLUTIONS IN WHICH THE EMOLITHIC LIFE OF NATURAL MICELLES TRAINING AGENTS IS AVOIDED BY THE ADDITION OF LIPOIDS AND RELATED PRODUCTS
CA1319886C (en) * 1987-02-03 1993-07-06 Alberto Ferro Mixed micelle solutions

Also Published As

Publication number Publication date
DD291696A5 (en) 1991-07-11
IE65555B1 (en) 1995-11-01
JPH03503899A (en) 1991-08-29
FI904892A0 (en) 1990-10-04
DE59005243D1 (en) 1994-05-11
AU4918690A (en) 1990-08-09
PT93055A (en) 1990-08-31
ATE103803T1 (en) 1994-04-15
HUT55219A (en) 1991-05-28
PT93055B (en) 1995-12-29
HU901153D0 (en) 1991-03-28
GR900100034A (en) 1991-06-28
EP0409936A1 (en) 1991-01-30
WO1990008534A1 (en) 1990-08-09
CA2009307A1 (en) 1990-08-06
IE900366L (en) 1990-08-06
HU206260B (en) 1992-10-28
ES2052246T3 (en) 1994-07-01
EP0409936B1 (en) 1994-04-06
DE3903753A1 (en) 1990-08-23
AU636327B2 (en) 1993-04-29

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