DEB0002789MA - Process for the preparation of the calcium salts of aromatic aminooxycarboxylic acids - Google Patents
Process for the preparation of the calcium salts of aromatic aminooxycarboxylic acidsInfo
- Publication number
- DEB0002789MA DEB0002789MA DEB0002789MA DE B0002789M A DEB0002789M A DE B0002789MA DE B0002789M A DEB0002789M A DE B0002789MA
- Authority
- DE
- Germany
- Prior art keywords
- parts
- calcium
- acids
- aromatic
- carbide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 159000000007 calcium salts Chemical class 0.000 title claims description 8
- -1 aromatic aminooxycarboxylic acids Chemical class 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 3
- 238000002360 preparation method Methods 0.000 title claims description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 8
- UIXRSLJINYRGFQ-UHFFFAOYSA-N Calcium carbide Chemical compound [Ca+2].[C-]#[C-] UIXRSLJINYRGFQ-UHFFFAOYSA-N 0.000 claims description 5
- 239000005997 Calcium carbide Substances 0.000 claims description 5
- 239000012442 inert solvent Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 2
- 238000001953 recrystallisation Methods 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-Aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 229960004909 aminosalicylic acid Drugs 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003701 inert diluent Substances 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 1
- JTXJZBMXQMTSQN-UHFFFAOYSA-N amino hydrogen carbonate Chemical compound NOC(O)=O JTXJZBMXQMTSQN-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Description
RÄ.2 37179*28.3.50RÄ. 2 37179 * 3/28/50
BADISGHE ANILIN- & SODA-PABRIK GL Farbenindustrie Aktiengesellschaft "In Auflösung11 BADISGHE ANILIN- & SODA-PABRIK GL Farbenindustrie Aktiengesellschaft "In dissolution 11
Unser Zeichens O.^Zg,^Our sign O. ^ Zg, ^
Ludwigshafen a.Rhein, den 27«März 1950 Fr/R.Ludwigshafen am Rhein, March 27, 1950 Fr / R.
Verfahren zur Herstellung der Calciumsalze aromatischerProcess for the preparation of the calcium salts more aromatic
Aminooxycarbonsäureru Aminooxycarboxylic acid u
Es wurde gefunden, dass man die Calciumsalze aromatischer Aminooxycarbonsäuren auf sehr einfache Weise herstellen kann, wenn man auf aromatische Amino oxy carbonsäuren in inerten Lösungs-*· oder Verdünnungsmitteln Calciumcarbid einwirken lässt»It has been found that the calcium salts of aromatic aminooxycarboxylic acids can be prepared in a very simple manner, if you let calcium carbide act on aromatic amino oxy carboxylic acids in inert solvents * · or diluents »
Die umsetzung geht so glatt vor sieh, dass es genügt, die Ausgangsstoffe bei gewöhnlicher Temperatur in dem Lösungs- oder Verdünnungsmittel aufeinander einwirken zu lassen» Man kann daher auch Lösungsmittel verwenden, die unter energischen Bedingungen evtle mit Calciumcarbid zu reagieren vermögen« Als Lösungs- - mittel konuaen in Betracht z.B. wasserfreie Alkohole, wie Methanol, Äther, wie Diäthyläther oder Tetrahydrofuran, Ester, wie Sssigsäureäthylester, aber auch solche, in denen weder die Ausgangsstoffe noch die Calciumsalze löslich sind, wie z.B.Kohlenwasserstoffe«, Man wendet die Lö'sungs- oder Verdünnungsmittel vorzugsweise wasserfrei an? obwohl ein geringer Gehalt an Sasser nichts 'schadet, da es durch das.Carbid rasch verbraucht wird und im Bndprodukt nicht mehr vorhanden isto The implementation goes so smoothly that it is sufficient to let the starting materials act on each other at normal temperature in the solvent or diluent »You can therefore also use solvents that may react with calcium carbide under energetic conditions« Medium conuaen into consideration, for example, anhydrous alcohols such as methanol, ethers such as diethyl ether or tetrahydrofuran, esters such as ethyl acetate, but also those in which neither the starting materials nor the calcium salts are soluble, such as hydrocarbons «, one uses the solution or Preferably anhydrous diluent ? although a low level of Sasser 'no harm, because it is rapidly consumed by das.Carbid and Bndprodukt no longer exists o
Aus dem ITmsetziingsgemisch lassen sich die Calciumsalze durch Eindampfen oder, wenn sie unlöslich sind« durch Abfiltrieren leicht gewinnen!. Sie sind, da au ihrer Herstellung keine Salze oder Hydroxide verwendet wurden, frei von Elektrolyten und Wasser, sojdass. 101/50 sie sich besonders gut für pliarmakologische Zwecke verwenden, lassen*The calcium salts can easily be removed from the IT reaction mixture by evaporation or, if they are insoluble, by filtering off to win!. Since no salts or hydroxides were used in their production, they are free of electrolytes and water, so that they are free of electrolytes. 101/50 they can be used particularly well for pliarmacological purposes, *
Claims (2)
Family
ID=
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