DE946179C - Process for the production of durable and highly effective solutions or suspensions of antibiotic agents - Google Patents

Description

Process for the production of durable and highly effective solutions or suspensions of antibiotic agents, addendum to patent 942 534 subject of patent 942 534 is a method of making durable and highly effective Solutions or suspensions of antibiotics, preferably penicillin or penicillin-streptomycin combinations, which is characterized in that an antibiotic, preferably penicillin or a penicillin combination and a watery full extract from an echinacea in one Suitable solvents or suspending agents for use in humans or Solvent mixture, preferably dissolved in water.

In the further processing of the procedure of the main patent was found that solutions or suspensions of the type described in the main patent by evaporation of the solution or

Let suspending agents be processed into dry preparations that can be kept for any length of time and are accordingly placed on the market as such can be, and that these dry preparations turn without difficulty can be transferred into injectable, well-tolerated solutions or suspensions. While the solutions or suspensions produced according to the procedure of Major patents are available, to be injected as such and to choose from the solvent or suspending agent according to the method of the main patent accordingly Care must be taken when choosing the solvent or suspending agent proceed more generously in accordance with the method of the present additional invention, because the solution resp.

Suspending agent again through the subsequent drying process removed. However, solvents or suspending agents are to be avoided Adsorption - even if only in traces - remain in the dry preparation and thereby could get into the final injectable solutions.

It is surprising that the dry preparations can be made because both the watery full extract from an Echinacea and the antibiotics are very good are sensitive - and especially the plant extracts are not without special precautionary measures or the use of carrier substances converted into powdery, dry products can be. Apart from that, it would have been expected that the dried preparations would be difficult to convert again into solutions or suspensions. The fact, that this is not the case is particularly surprising.

Probably takes place during the dissolving or suspension and drying process a mutual chemical influence of the two components takes place, possibly in the form of a physicochemical adsorption, through which the behavior of the components is to be explained during the drying and the dissolving or suspension process.

This is also supported by the fact that, for example, that from oxyprocaine penicillin and echinacin produced dry preparation has a particularly good solubility.

The dry preparations can be filled into ampoules or bottles. The doctor can easily identify the injectable just before the injection Prepare solution or suspension.

The dry preparations can also be used as such in the medical field Practice to be used.

The drying process of the starting solution or suspension must be natural taking into account the sensitive nature of the two components as much as possible be carried out more gently. Freeze-drying has proven to be particularly suitable proven in which the solution or. Suspending agent, preferably the water, im Vacuum at very low temperatures (o to 400 C) is evaporated. You can use the solution or. Suspension medium, preferably water, but also in other forms, for example remove by vacuum treatment at temperatures above oO C. Temperatures above go0 C should not be used if possible to prevent damage to the components to avoid.

Example 1 800 mg of oxyprocaine penicillin are mixed with 4 cm3 of an aqueous Treated echinacin solution and then until it reaches a particle size mill from about 5 to 20 microns.

The mixture is then at low temperatures up to about 400 C im Vacuum dried, after which the reaction product is obtained as a loose powder.

Example 2 400 mg -very finely crystalline oxyprocaine-penicillin treated it is mixed with 2 cm3 of aqueous echinacin solution, thoroughly rubbed in a mortar and then removed the water at about 400 C in a vacuum. The product obtained is mixed with 15 cc of water poured over it and then heated to 60 to 650 ° C. within 2 minutes with thorough stirring. The aqueous solution obtained is evaporated to dryness in vacuo at 400 C, after which a loose powder is obtained, which ini contrasts with oxyprocaine penicillin is easily soluble in water.

Example 3 Dissolve 1 g of oxyprocaine penicillin in 30 cm3 of alcohol, then add the same volume of acetone and then 5 cmS of aqueous echinacin solution. the organic solvents are then removed in vacuo at room temperature. To Adding 50 cm5 of dry benzene, the remaining water is azeotroped Removed distillation under reduced pressure, after which the reaction product as loose powder is obtained.

Claims (1)

PATENT CLAIM: Process for the production of durable and effective Solutions or suspensions of antibiotics, preferably of penicillin or penicillin combinations according to patent 942534, characterized in that the common solution or suspension of the antibiotic and the plant extract in cautious form, preferably on is converted into dry preparations by freeze-drying and this dry preparation is optionally converted into a solution or suspension. Publications considered: Vogel, "Die Antibiotika", I95I, Pp.365; "Pharmazie", 1950, p.2I0; “Med. Klinik ", I94I, p. 276; F i s c h e r »Zahnärztl. Advanced training «, 1939; M ei x n e r, »Ärztl. Praxis «, 1950; U 11 man, »Apparatus construction in process engineering «, 195I, vol, p.559; N e um an n, "Floor plan of the freeze-drying", I952.