DE9200543U1 - Ataxie-Medikament in dem a-Liponsäure + Pantothensäure bzw. Dexpanthenol kombiniert sind (auch gegen MS, Muskelatrophie, Polyneuropathie usw.) - Google Patents
Ataxie-Medikament in dem a-Liponsäure + Pantothensäure bzw. Dexpanthenol kombiniert sind (auch gegen MS, Muskelatrophie, Polyneuropathie usw.)Info
- Publication number
- DE9200543U1 DE9200543U1 DE9200543U DE9200543U DE9200543U1 DE 9200543 U1 DE9200543 U1 DE 9200543U1 DE 9200543 U DE9200543 U DE 9200543U DE 9200543 U DE9200543 U DE 9200543U DE 9200543 U1 DE9200543 U1 DE 9200543U1
- Authority
- DE
- Germany
- Prior art keywords
- acid
- energy
- ataxia
- acetylcholine
- dexpanthenol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 title description 4
- 206010003591 Ataxia Diseases 0.000 title description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 title description 2
- 201000000585 muscular atrophy Diseases 0.000 title description 2
- 229940055726 pantothenic acid Drugs 0.000 title description 2
- 235000019161 pantothenic acid Nutrition 0.000 title description 2
- 239000011713 pantothenic acid Substances 0.000 title description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 title 1
- 235000004866 D-panthenol Nutrition 0.000 title 1
- 239000011703 D-panthenol Substances 0.000 title 1
- 206010036105 Polyneuropathy Diseases 0.000 title 1
- 229960003949 dexpanthenol Drugs 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 title 1
- 230000007824 polyneuropathy Effects 0.000 title 1
- 239000000126 substance Substances 0.000 claims description 4
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 claims description 3
- 229960004373 acetylcholine Drugs 0.000 claims description 3
- 210000003205 muscle Anatomy 0.000 claims description 2
- 210000005036 nerve Anatomy 0.000 claims description 2
- 230000004102 tricarboxylic acid cycle Effects 0.000 claims description 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 4
- -1 Glucose Pyruvic acid Acetoacetic acid Ketone Chemical class 0.000 claims 3
- XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 claims 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 2
- XTWYTFMLZFPYCI-UHFFFAOYSA-N Adenosine diphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(O)=O)C(O)C1O XTWYTFMLZFPYCI-UHFFFAOYSA-N 0.000 claims 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 claims 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 229920002527 Glycogen Polymers 0.000 claims 2
- DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 claims 2
- 229940100228 acetyl coenzyme a Drugs 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 229940096919 glycogen Drugs 0.000 claims 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 108010007979 Glycocholic Acid Proteins 0.000 claims 1
- 102000001554 Hemoglobins Human genes 0.000 claims 1
- 108010054147 Hemoglobins Proteins 0.000 claims 1
- RFDAIACWWDREDC-UHFFFAOYSA-N Na salt-Glycocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCC(O)=O)C)C1(C)C(O)C2 RFDAIACWWDREDC-UHFFFAOYSA-N 0.000 claims 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 229960003624 creatine Drugs 0.000 claims 1
- 239000006046 creatine Substances 0.000 claims 1
- 229940109239 creatinine Drugs 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 1
- 229960003180 glutathione Drugs 0.000 claims 1
- 235000003969 glutathione Nutrition 0.000 claims 1
- 229940099347 glycocholic acid Drugs 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229940116269 uric acid Drugs 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 description 3
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 description 1
- 208000007379 Muscle Hypotonia Diseases 0.000 description 1
- 206010028289 Muscle atrophy Diseases 0.000 description 1
- 206010060860 Neurological symptom Diseases 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 description 1
- 239000005516 coenzyme A Substances 0.000 description 1
- 229940093530 coenzyme a Drugs 0.000 description 1
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 230000020763 muscle atrophy Effects 0.000 description 1
- 201000006938 muscular dystrophy Diseases 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
of-Liponsäure trägt* '; " - -"Oe'xp'ähtiienol bzw. Pantothensäure
zur Bildung der trägt zur Bildung des
Acetylreste bei Coenzyms A bei
Ausgangssubstanz des Zitronensäurezyklus = wichtigste Energiequelle aller Zellen und des peripheren Nervensystems.
Ideale Behandlungsmethode gegen MultipleSklerose, Ataxie,
Muskelatrophie, Muskelhypotonie und evtl. auch Muskeldystrophie,
Die Kombination beider Präparate regt den Zellstoffwechsel
an und gleicht neurologische Symptome aus. Besonders durch die Bildung von mehr ATP (chemischer Energieträger) und
mehr Acetylcholin (Überträgersubstanz von Nerven auf den Muskel).
Claims (2)
- Kohlenhydrate
GlykogenU &tgr;=*Eiweiß Peptide und AminosäurenGlukoseBrenztraubensäureAcetessigsäure KetonkörperGlykogen+EnergieGlyzinAcetyl-Coenzym A(2-Kohlenstoffkörper)GlutathionKreatin - 2)KreatininGlykocholsäure PorphyrineHämoglobin BilirubinPurinbasen/ VNuklein- Harnsäure säureTrikarbonsäure-Zyklus O + EnergieFetteFettsäurenAcetylierte KörperAcetylcholin Acetylphosphat AcetylsulfonamidFettsäuren CholesterinZur Erläuterung der zentralen Stellung des Acetyl-Coenzym A Stoffwechsels (nach Popper & Schaffner 1961)Acetylcholin = Überträgersubstanz von Nerven auf Muskeln.Kreatinphosphat = energiereiches Molekül, dessen Energie rasch zur Verfügung steht, um ATP (Adenosintriphosphat = ehem. Energieträger) aus ADP (Adenosindiphosphat) zu bilden.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE9200543U DE9200543U1 (de) | 1992-01-18 | 1992-01-18 | Ataxie-Medikament in dem a-Liponsäure + Pantothensäure bzw. Dexpanthenol kombiniert sind (auch gegen MS, Muskelatrophie, Polyneuropathie usw.) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE9200543U DE9200543U1 (de) | 1992-01-18 | 1992-01-18 | Ataxie-Medikament in dem a-Liponsäure + Pantothensäure bzw. Dexpanthenol kombiniert sind (auch gegen MS, Muskelatrophie, Polyneuropathie usw.) |
Publications (1)
Publication Number | Publication Date |
---|---|
DE9200543U1 true DE9200543U1 (de) | 1992-05-07 |
Family
ID=6875136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE9200543U Expired - Lifetime DE9200543U1 (de) | 1992-01-18 | 1992-01-18 | Ataxie-Medikament in dem a-Liponsäure + Pantothensäure bzw. Dexpanthenol kombiniert sind (auch gegen MS, Muskelatrophie, Polyneuropathie usw.) |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE9200543U1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0572922A1 (de) * | 1992-06-05 | 1993-12-08 | ASTA Medica Aktiengesellschaft | Synergistische Kombination von Liponsäure und Vitaminen in Arzneimitteln |
DE4320117A1 (de) * | 1992-01-18 | 1994-12-22 | Margarethe Rabien | Kombinatinspräparate |
-
1992
- 1992-01-18 DE DE9200543U patent/DE9200543U1/de not_active Expired - Lifetime
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4320117A1 (de) * | 1992-01-18 | 1994-12-22 | Margarethe Rabien | Kombinatinspräparate |
EP0572922A1 (de) * | 1992-06-05 | 1993-12-08 | ASTA Medica Aktiengesellschaft | Synergistische Kombination von Liponsäure und Vitaminen in Arzneimitteln |
DE4218572A1 (de) * | 1992-06-05 | 1993-12-09 | Asta Medica Ag | Synergistische Kombination von Arzneimitteln enthaltend als Wirkstoff alpha-Liponsäure, Dihydroliponsäure, deren Metaboliten sowie die oxidierten und reduzierten Enantiomere der alpha-Liponsäure wie die R-alpha-Liponsäure oder S-alpha-Liponsäure sowie Metaboliten der alpha-Liponsäure mit den Vitaminen A, B1-6, B12, C und E |
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