DE882894C - Radioactive contrast medium - Google Patents
Radioactive contrast mediumInfo
- Publication number
- DE882894C DE882894C DESCH5826A DESC005826A DE882894C DE 882894 C DE882894 C DE 882894C DE SCH5826 A DESCH5826 A DE SCH5826A DE SC005826 A DESC005826 A DE SC005826A DE 882894 C DE882894 C DE 882894C
- Authority
- DE
- Germany
- Prior art keywords
- radioactive
- contrast medium
- compounds
- halogen
- iodine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000002285 radioactive effect Effects 0.000 title claims description 13
- 239000002872 contrast media Substances 0.000 title claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 150000002367 halogens Chemical class 0.000 claims description 6
- 150000002896 organic halogen compounds Chemical class 0.000 claims description 5
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 4
- 229910052740 iodine Inorganic materials 0.000 claims description 4
- 239000011630 iodine Substances 0.000 claims description 4
- 150000002497 iodine compounds Chemical class 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 210000000232 gallbladder Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 description 7
- 229940039231 contrast media Drugs 0.000 description 5
- 238000009826 distribution Methods 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 206010021703 Indifference Diseases 0.000 description 1
- ZVAKTWSQIIRIIH-UHFFFAOYSA-N [K].[I] Chemical compound [K].[I] ZVAKTWSQIIRIIH-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 150000002366 halogen compounds Chemical class 0.000 description 1
- 230000002140 halogenating effect Effects 0.000 description 1
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Description
Radioaktives Röntgenkontrastmittel Eine Reihe von organischen Halogenverhindungen, inshesondere Jodverbindungen, von physiologischer Indifferenz sind als gute Kontrastmittel zur röntgenologischen Sichtbarmachung von Körperorganen, wie der Galle, Niere u. dgl., bekannt (vgl. z. B. die deutschen Patentschriften 454641, 704549 7016 938, 739 634, 5o6 425, 5312 766, 659 496, 545 916, 553 823, 579 22ßj. Bei diesen Kontrastmitteln konnte man bisher die fortschreitende Resorption, Verteilung und Anreicherung in den Organen des Körpers nur durch Serienaufuahmen von Röntgenhildern zu verschiedenen Zeiten fest-. stellen, also durch ein Verfahren, welches Zeit und Kosten beanspruchte. Außerdem war es dabei nicht möglich festzustellen, ob nicht eine geringe Menge des Halogens in organischer Bindung oder in freiem Zustand zu Organen abgewandert war, in denen seine Anwesenheit nicht erwünscht war, z. B. in die Schilddrüse.Radioactive X-ray contrast medium A range of organic halogen compounds, Iodine compounds in particular, of physiological indifference, are good contrast media for radiological visualization of body organs, such as the bile, kidney and the like. Like., known (see, for example, German patents 454641, 704549 7016 938, 739 634, 5o6 425, 5312 766, 659 496, 545 916, 553 823, 579 22ßj. With these contrast media So far one could see the progressive absorption, distribution and accumulation in the organs of the body only by taking a series of X-ray images Fixed times. through a process that took time and money. In addition, it was not possible to determine whether a small amount of the Halogen in organic bonds or in the free state had migrated to organs, where his presence was not wanted, e.g. B. in the thyroid.
Es wurde nun gefunden, daß man die Resorption, Verteilung und Anreicherung solcher organischen Halogenverbindungen in den Organen des Körpers einwandfrei beobachten kann, wenn man als Kontrastmittel solche organischen Halogenverbindungen verwendet, die radioaktives Halogen, vorzugsweise radioaktives Jod, enthalten. Nach Verabreichung des Kontrastmittels kann mit Hilfe geeigneter Geräte, z. B. durch Messung der Impulse mittels des Geiger-Müller-Gerätes, die Resorption. It has now been found that absorption, distribution and accumulation can be achieved Observe such organic halogen compounds in the organs of the body properly can, if such organic halogen compounds are used as contrast media, which contain radioactive halogen, preferably radioactive iodine. After administration the contrast agent can be carried out with the help of suitable equipment, e.g. B. by measuring the pulses by means of the Geiger-Müller device, the resorption.
Verteilung und Konzentration der Halogenver bindungen in den Körperorganen verfolgt und der günstigste Zeitpunkt für die Röntgenaufnahme gefunden werden. Außerdem werden bei Anwendung dieser Kontrastmittel durch Bestimmung der Geschwindigkeit der Anreicherung und des Verschwindens der Aktivität in den Organen wichtige .Äufschlüsse über die Funktion derselben, besonders der Niere und der Leber erhalten.Distribution and concentration of Halogenver compounds in the body organs tracked and the most convenient time for the X-ray to be found. aside from that are determined when using this contrast agent by determining the speed important conclusions about the accumulation and disappearance of the activity in the organs about the function of the same, especially of the kidneys and liver.
Die Herstellung der beanspruchten Röntgenkontrastmittel erfolgt auf die zur Einführung von radioaktiven Halogen, vorzugsweise radioaktivem Jod, in organische Verbindungen üblicher Weise, insbesondere dadurch, daß dem Halogenierungsmittel radioaktives Halogen in einer solchen Menge zugesetzt wird, daß die erhaltene Halogenverbinidung je nach dem Verwendungszweck eine Aktivität von etwa 25 bis 220 µ C je Gramm Substanz entwickelt. The claimed X-ray contrast media are produced on those for introducing radioactive halogen, preferably radioactive iodine, into organic Compounds in the usual manner, especially in that the halogenating agent radioactive halogen is added in such an amount that the halogen compound obtained Depending on the intended use, an activity of about 25 to 220 µC per gram of substance developed.
Das radioaktive Halogen kann nach verschiedenen, an sich bekannten Verfahren hergestellt werden, z. B. kann man radioaktives Jod aus radioaktivem Jodkalium erhalten, indem es aus diesem in üblicher Weise durch Jodat frei gemacht wird. Da es sich jeweils um Bruchteile eines Milligramms von zur Reaktion benötigten Jodisotopen handelt, braucht dieser Zusatz bezüglich der stöchiometrischen Verhältnisse bei der Herstellung nicht berücksichtigt zu werden. Als Ausgangsstoffe sind alle als Kontrastmittel bereits bekannten organischen Halogenverbindungen, wie sie z. B. in den deutschen Patentschriften +54 64i, 704 549, 7oi6 938, 739 634, 506425, 532 7616, 659496, 545916, 553823, 579wl2t4 beschrieben sind, anwendbar, unabhängig von ihrer Wasserlöslichkeit, deren Einfluß auf die Verteilung der Mittel in den Organen des Körpers durch die Aktivierung keine Änderung erfährt.The radioactive halogen can be according to various known per se Processes are produced, e.g. B. one can radioactive iodine from radioactive iodine potassium obtained by making it free from this in the usual way by iodate. There each is a fraction of a milligram of iodine isotopes required for the reaction acts, this addition needs with respect to the stoichiometric ratios not to be taken into account during manufacture. The starting materials are all as Contrast media already known organic halogen compounds, such as those used, for. B. in German patents +54 64i, 704 549, 7oi6 938, 739 634, 506425, 532 7616, 659496, 545916, 553823, 579wl2t4 are applicable regardless of their solubility in water, their influence on the distribution of the funds in the organs of the body does not experience any change through activation.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DESCH5826A DE882894C (en) | 1950-10-24 | 1950-10-24 | Radioactive contrast medium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DESCH5826A DE882894C (en) | 1950-10-24 | 1950-10-24 | Radioactive contrast medium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE882894C true DE882894C (en) | 1953-07-13 |
Family
ID=7424650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DESCH5826A Expired DE882894C (en) | 1950-10-24 | 1950-10-24 | Radioactive contrast medium |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE882894C (en) |
-
1950
- 1950-10-24 DE DESCH5826A patent/DE882894C/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69320481T2 (en) | TETRAAZAMACROCYCLIC METAL COMPLEXES | |
| DE68909245T2 (en) | TRANSITION METAL NITROGEN COMPLEX CONTAINING RADIOPHARMACEUTICAL PRODUCT WITH AN INCLINATION TO HEART TISSUE. | |
| DE2606721A1 (en) | RADIOACTIVE MEDICINAL | |
| DE2947500C2 (en) | Radioiodinated? -Phenyl fatty acids, their production and their use for the scintigraphic examination of the heart muscle and the liver | |
| DE882894C (en) | Radioactive contrast medium | |
| DE102007045313A1 (en) | Method and device for the separate three-dimensional representation of arteries and veins in an examination object and device | |
| DE2447556A1 (en) | RADIOPHARMACEUTICAL | |
| DE69728069T2 (en) | PRODUCTION OF FERROCENYLPHENYLTROPAN ANALOGS, AND THEIR CONVERSION TO TECHNETIUM-MARKED NEUROSONDES FOR DETECTING MONOAMINE RECOVERY SITES | |
| DE2124751A1 (en) | Process for the production of a diagnostic preparation based on an iron complex labeled with 99mTc | |
| EP0019790B1 (en) | Technetium-99m labeled acetanilidoiminodiacetates for liver function diagnosis and process for their preparation | |
| Kreibich et al. | Zur Chemie des Phorbols, V: Über einige Äther des Phorbols | |
| DE2260933B2 (en) | Process for the preparation of radioactive halogen labeled organic compounds | |
| DE1964100A1 (en) | New, radioactively labeled derivatives of difluoresceinylmercury and processes for their production | |
| Lawson | Hepatography with Oily Contrast Agents: Preliminary Report | |
| DE19641197A1 (en) | Ion pairs, processes for their preparation and their use as contrast agents | |
| DE647380C (en) | Process for solubilizing hexamethylene tetramine silver salicylate in water | |
| DE1814671A1 (en) | New fluorescein derivatives labeled with radioactive mercury isotopes and processes for their production | |
| DE2728271C2 (en) | ||
| DE705985C (en) | Radio receiver with built-in loudspeaker and large-scale drum scale | |
| DE69824147T2 (en) | Technetium-99m labeled diethylenetriamine pentaacetic acid diesters and process for their preparation | |
| DD225789A1 (en) | METHOD FOR IMPROVING NUCLEAR PNINTOMOGRAPHIC MEASUREMENTS OF BIOLOGICAL OBJECTS | |
| Scheer et al. | Phasenbilder renaler Ausscheidung mit der Szintillationskamera | |
| DE468710C (en) | Process for stabilizing solid alcoholic iodine solutions | |
| DE1473038C (en) | Method for determining the flow strength of a flowing medium | |
| DE652594C (en) | Roentgenological procedure |