DE859350C - Process for obtaining pure physodic acid from lichens - Google Patents

Process for obtaining pure physodic acid from lichens

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Publication number
DE859350C
DE859350C DEK6306A DEK0006306A DE859350C DE 859350 C DE859350 C DE 859350C DE K6306 A DEK6306 A DE K6306A DE K0006306 A DEK0006306 A DE K0006306A DE 859350 C DE859350 C DE 859350C
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Germany
Prior art keywords
acid
physodic
lichens
obtaining pure
pure
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Expired
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DEK6306A
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German (de)
Inventor
Josef Dipl-Chem Dr Rer N Klosa
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Individual
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Individual
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Priority to DEK6306A priority Critical patent/DE859350C/en
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Publication of DE859350C publication Critical patent/DE859350C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/09—Lichens

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Description

Verfahren zur Gewinnung der reinen Physodsäure aus Flechten Nach den neueren Untersuchungen von J. Klos a, Still (Schweiz) und Marshak (Chikago) führen die Flechten hochaktive Substanzen, die gegen bakterielle und parasitäre Erreger wirksam sind.Process for obtaining the pure physodic acid from lichens According to the more recent studies by J. Klos a, Still (Switzerland) and Marshak (Chicago) lead the lichen highly active substances that fight bacterial and parasitic pathogens are effective.

Sie sind als Heilmittel gegen obige Erankheitserreger geeignet, wobei sie fast ungiftig sind und wertvolle Eigenschaften vor anderen chemotherapeutischen Stoffen entfalten.They are suitable as a remedy for the above pathogens, whereby they are almost non-toxic and have valuable properties over other chemotherapeutic ones Unfold fabrics.

Von Marshak (Puhl. Health reports 3, IO [1947]) wurde als antibiotischer Körper nur die Usninsäure näher untersucht, dasselbe gilt auch von 5 tell und Mitarbeitern (Experientia 3 111 FI947]). Nun wurde schon vor längerer Zeit die Beobachtung gemacht, daß auch die Physodsäure ähnliche, wenn nicht noch hessere antibiotische Eigenschaften entfaltet. Eine Zusammenstellung aller Flechtenstoffe, die antibiotisch wirksam befunden wurden, wird demnächst in einer medizinischen Monatsschrift erscheinen. Man kann zwar den Gesamtkomplex der antibintisch wirksamen Körper gewinnen, jedoch scheint es besser zu sein, die reinen wirksamen Körper gesondert zu isolieren, um von diesen aus unter Umständen noch wirksamere Derivate mit besonderen Eigenschaften aufzubauen. Die Physodsäure kann aber nach der Zusaminenstellung der. Flechtenliteratur nach Zopf (Fischer-Jena I909) nur nach umfangreichen Trennungs- und Reinigungsoperationen isoliert werden. Es wurde nun die Beobachtung gemacht, daß man die Physodsäure schon hinreichend rein direkt aus Flechten, insbesondere der Gattung Parmalina physodes, gewinnen kann, wenn man die Flechten mit Chloroform als Lösungsmittel extrahiert. Die Physodsäure kristallisiert bereits beim Erkalten der Chloroformlösung in farblosen, langen Kristallen aus, die bei 198° C schmelzen; nach Umkristallisieren aus Essigester zeigen sie einen konstanten Schmelzpunkt von 2020 C. By Marshak (Puhl. Health reports 3, IO [1947]) was called antibiotic Body only examined usnic acid more closely; the same is also true of Tell et al (Experientia 3 111 FI947]). Now the observation was made a long time ago that physodic acid also has similar, if not even better, antibiotic properties unfolds. A compilation of all lichen substances that have an antibiotic effect will soon appear in a medical monthly. It is true that the entire complex of the antibiotic effective bodies can be obtained, however it seems to be better to isolate the pure active bodies separately in order to from these, derivatives with special properties may be even more effective build up. The physodic acid can, however, according to the composition of the. Lichen literature according to Zopf (Fischer-Jena I909) only after extensive separation and cleaning operations to be isolated. The observation has now been made that the physodic acid is already sufficiently pure directly from lichens, especially of the genus Parmalina physodes, can be obtained by extracting the lichens with chloroform as a solvent. The physodic acid already crystallizes at Cooling of the chloroform solution in colorless, long crystals that melt at 198 ° C; after recrystallization from ethyl acetate they show a constant melting point of 2020 C.

Die so dargestellte Physodsäure ist wirksam gegen eine große Anzahl von Ealiterien, sie ist relativ rein und ungiftig und kann im Tierversuch durch Injektion einverleibt werden. Sie ist in Alkalten unter Braunfärbung löslich, ferner löslich in Alkohol, Aceton, Chloroform, Benzylalkohol und Satriumhicarbonatlölsung. dagegen unlöslich in Wasser. The physodic acid thus prepared is effective against a large number from Ealiteria, it is relatively pure and non-toxic and can be tested on animals Injection. It is also soluble in alkali with a brown coloration soluble in alcohol, acetone, chloroform, benzyl alcohol and sodium bicarbonate solution. on the other hand, insoluble in water.

Beispiel 100 g Flechten Parmalina physodes werden im Soxhlet-Extraktionsapparat mit 250 ccm Chloroform 40 Minuten extrahiert. Nach dem Verdampfen des Chloroforms auf 100 ccm und langsamem Erkalten kristallisiert die Physodsäure rein heraus. Sie wird abfiltriert und aus Essigester wieder umkristallisiert. Die Mutterlaugen enthalten noch geringe Mengen Physodsäure und weitere antibiotisch wirksame Körper. Schmelzpunkt der reinen Physodsäure ist 2O20C. Example 100 g of lichen Parmalina physodes are put in a Soxhlet extraction apparatus extracted with 250 cc chloroform for 40 minutes. After evaporation of the chloroform on 100 ccm and slowly cooling, the physodic acid crystallizes out in pure form. she is filtered off and recrystallized again from ethyl acetate. The mother liquors contain still small amounts of physodic acid and other antibiotic active bodies. Melting point the pure physodic acid is 2O20C.

Claims (2)

PATENTANSPRÜCHE: r; Verfahren zur Gewinnung reiner Physodsäure aus Flechten, dadurch gekennzeichnet, daß die Flechten mit Chloroform extrahiert werden. PATENT CLAIMS: r; Process for obtaining pure physodic acid from Lichen, characterized in that the lichens are extracted with chloroform. 2. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß als Ausgangsmaterial Flechten der Gattung Parmalina physodes verwendet werden. 2. The method according to claim 1, characterized in that the starting material Lichen of the genus Parmalina physodes can be used.
DEK6306A 1950-07-05 1950-07-05 Process for obtaining pure physodic acid from lichens Expired DE859350C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEK6306A DE859350C (en) 1950-07-05 1950-07-05 Process for obtaining pure physodic acid from lichens

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEK6306A DE859350C (en) 1950-07-05 1950-07-05 Process for obtaining pure physodic acid from lichens

Publications (1)

Publication Number Publication Date
DE859350C true DE859350C (en) 1952-12-15

Family

ID=7211248

Family Applications (1)

Application Number Title Priority Date Filing Date
DEK6306A Expired DE859350C (en) 1950-07-05 1950-07-05 Process for obtaining pure physodic acid from lichens

Country Status (1)

Country Link
DE (1) DE859350C (en)

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