DE800877C - Disinfectants and preservatives - Google Patents
Disinfectants and preservativesInfo
- Publication number
- DE800877C DE800877C DEP13038A DEP0013038A DE800877C DE 800877 C DE800877 C DE 800877C DE P13038 A DEP13038 A DE P13038A DE P0013038 A DEP0013038 A DE P0013038A DE 800877 C DE800877 C DE 800877C
- Authority
- DE
- Germany
- Prior art keywords
- dioxy
- dimethyldiphenyl
- cresol
- disinfectants
- preservatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003755 preservative agent Substances 0.000 title claims description 6
- 239000000645 desinfectant Substances 0.000 title claims description 5
- 150000003839 salts Chemical class 0.000 claims description 2
- QWVGKYWNOKOFNN-UHFFFAOYSA-N o-cresol Chemical compound CC1=CC=CC=C1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 description 10
- 239000002253 acid Substances 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 230000002335 preservative effect Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000008121 dextrose Substances 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 235000015197 apple juice Nutrition 0.000 description 1
- CUBCNYWQJHBXIY-UHFFFAOYSA-N benzoic acid;2-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1O CUBCNYWQJHBXIY-UHFFFAOYSA-N 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 229930003836 cresol Natural products 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
(WiGBl. S. 175)(WiGBl. P. 175)
AUSGEGEBEN AM 11. DEZEMBER 1950ISSUED DECEMBER 11, 1950
ρ τ3038 II' a j 30 i Dρ τ3038 II 'a j 30 i D
Es wurde gefunden, daß 4, 4'-Dioxy-3, 3'-dimethvldiphenyl eine überraschend starke Wirkung als Konservierung*- und Desinfektionsmittel aufweist. Vergleichende Versuche zur Gärungshemmung hei Traubenzuckerbouillon und Hefe enthaltenden Gärlösungen ergaben z. H. gegenüber den vielfach als Konservierungsmittel gebrauchten p-Oxybenzoesäureestern die folgenden Konzentrationen, bei welchen innerhalb von 14 Tagen noch Hemmung eintritt:It has been found that 4,4'-dioxy-3, 3'-dimethyl diphenyl has a surprisingly strong effect as a preservative * and disinfectant. Comparative attempts to inhibit fermentation in dextrose bouillon and yeast containing Fermentation solutions resulted in z. H. compared to the often used as a preservative p-Oxybenzoic acid esters the following concentrations, at which within 14 days Inhibition occurs:
Ph 3. 5 Ph 4. 5~6 Neutralpunkt p-Oxybenzoesäureester 1:5 000 1:1000 >als 1:1000 4,4'-Dioxy-3,3'-Ph 3.5 Ph 4.5 ~ 6 neutral point p-oxybenzoic acid ester 1: 5,000 1: 1000 > as 1: 1000 4,4'-dioxy-3,3'-
dimethyldiphenyl 1:20000 1:5000 1:2000dimethyldiphenyl 1: 20000 1: 5000 1: 2000
Ähnliche Ergebnisse wurden bei Versuchen zur Hemmung des Schimnielpilzwachstums auf Apfelsaft erhaltenSimilar results were obtained from attempts to inhibit mold growth on apple juice obtain
bei p-Oxybenzoesäureestern 1 : 2000,for p-oxybenzoic acid esters 1: 2000,
bei 4. 4'-Dioxy-3, 3'-dimethyldiphenyl 1:10000.at 4. 4'-dioxy-3,3'-dimethyldiphenyl 1: 10000.
Hei Vergleichsversuchen mit Benzoesäure und Salicylsäure, die bei einem pn von 4 nur bei ι : rooo bis ι : 2000, bei Pij(i sogar unter 1 : τ000 hemmten, wurden für 4, 4'-Dioxy-3, 3'-dimethyldiphenyl dieselben günstigen Konzentrationen wie oben gefunden.Hei comparison tests with benzoic acid and salicylic acid, which with a pn of 4 only with ι: rooo up to ι: 2000, at Pij (i even inhibited below 1: τ000, became the same for 4,4'-dioxy-3, 3'-dimethyldiphenyl favorable concentrations as found above.
Eine besonders hohe Wirksamkeit besitzt 4. 4'-Dioxy-3, 3'-ditnethyldiphenvl gegenüber pathogenen Bakterien. So wurde das Wachstum von Staphylococcus aureus Stamm FT im Verdünnungsreihentest bei Oberflächenbeimpfung in einer Verdünnung von ι : 50000 bis 1 : 100 000 gehemmt, gegenüber Kresol 1 : 2000 und p-Oxybenzoesäureester 1 : 1000 bis ι : 2000.4. 4'-Dioxy-3,3'-diethyldiphenyl is particularly effective against pathogens Bacteria. Thus, the growth of Staphylococcus aureus strain FT in the dilution series test with surface inoculation in a dilution of ι: 50,000 to 1: 100,000 inhibited, compared to Cresol 1: 2000 and p-oxybenzoic acid ester 1: 1000 until ι: 2000.
Der Vergleich mit o-Kresol ergab folgende Hemmungsgrenzen im Gärungsversuch (20°/oige Traubenzuckerbouillon mit Bäckerhefe):The comparison with o-cresol showed the following inhibition limits in the fermentation test (20% dextrose bouillon with baker's yeast):
o-Kresol 1 : 2000,o-cresol 1: 2000,
4, 4'-I)ioxy-3, 3'-dimethyldiphenyl 1 : 10 000; gegenüber Schimmelpilz:4, 4'-I) ioxy-3, 3'-dimethyldiphenyl 1: 10,000; against mold:
o-Kresol 1 : 2000,o-cresol 1: 2000,
4, 4'-Dioxy-3,3'-dimethyldiphenyl r: iobis2oooo; gegenüber Staphylococcus aureus:4,4'-Dioxy-3,3'-dimethyldiphenyl r: iobis2oooo; against Staphylococcus aureus:
o-Kresol 1 : 2000,o-cresol 1: 2000,
4, 4'"Di°xy~3>
3'-dimethyldiphenyl ι : 50 bis
ι oo ooo.4, 4 '"Di ° x y ~ 3>3'-dimethyldiphenyl ι: 50 to
ι oo ooo.
Beim vergleichenden Desinfektionsversuch (Konzentration/Zeitmethode) wurden folgende Werte gefunden: In a comparative disinfection attempt (concentration / time method) the following values were found:
4, 4'-Dioxy-3, 3'-dimethyldiphenyl 1 : 1000 nach4,4'-Dioxy-3, 3'-dimethyldiphenyl 1: 1000 according to
6 Minuten Sterilisierung,
Phenol 1 : 100 Abtötung nach 3 Stunden,
o-Kresol 1 : 100 nach 1A Stunde keine Sterilisierung.
6 minutes sterilization,
Phenol 1: 100 kill after 3 hours,
o-cresol 1: 100 after 1 ½ hour no sterilization.
Die Toxizität von 4, 4'-Dioxy-3, 3'-dimethyldiphenyl ist sehr günstig: Die Dosis letalis med. beträgt an der weißen Maus etwa 1,5 g pro Kilogramm per os. Im Dauerversuch wurden sechs Mäusen täglich 200 mg/kg 30 Tage lang verabreicht. Dabei traten keine toxischen Erscheinungen auf. Nachomaliger Verabreichung von je 200 mg/kg per os an drei Kaninchen ergab sich weder eine Beeinflussung des Hämoglobins noch eine Veränderung des Blutbildes.The toxicity of 4,4'-dioxy-3, 3'-dimethyldiphenyl is very cheap: the dose letalis med. is about 1.5 g per kilogram on the white mouse per os. In the long-term experiment, six mice were administered 200 mg / kg daily for 30 days. No toxic phenomena occurred. Subsequent administration of 200 mg / kg each Per os on three rabbits there was neither an influence on the hemoglobin nor a change the blood count.
4, 4'-Dioxy-3, 3'-dimethyldiphenyl als Desinfektionsmittel besitzt ferner besondere Vorzüge in seiner Kochbeständigkeit, seiner Geruch- und Geschmacklosigkeit und in seiner guten \rerträglich- ; keit. Die Substanz kann als solche oder in Form ihrer Salze, ζ. B. in Form ihrer Alkalisalze allein oder zusammen mit anderen Stoffen verwendet werden, wobei sie dem zu konservierenden Material trocken oder in Lösung zugesetzt wird. Sie kann aber auch als Desinfektions- und Konservierungsmittel Emulsionen, Pudern und Pasten beigemischt werden.4, 4'-Dioxy-3, 3'-dimethyldiphenyl as a disinfectant also has particular advantages in its resistance to cooking, its odorless and tastelessness and its good \ r tolerable; speed. The substance can be used as such or in the form of its salts, ζ. B. can be used in the form of their alkali salts alone or together with other substances, being added to the material to be preserved dry or in solution. However, it can also be added to emulsions, powders and pastes as a disinfectant and preservative.
Zur Anwendung des 4, 4'-Dioxy-3, 3'dimethyldiphenyls als Konservierungsmittel löst man die erforderliche Menge des Stoffes entweder direkt in dem zu konservierenden Material, gegebenenfalls unter Erhitzen, oder man stellt eine alkoholische Lösung des Stoffes her und gießt dieselbe in das zu konservierende Gut. Man kann 4, 4'-Dioxy-3, 3'-dimethyldiphenyl aber auch in einem Unterschuß von Lauge lösen und diese Lösung dem zu konservierenden Material zusetzen.To use the 4,4'-dioxy-3, 3'dimethyldiphenyls as a preservative, dissolve the required amount of the substance either directly in the material to be preserved, if necessary with heating, or one puts an alcoholic Solution of the substance and pour the same into the goods to be preserved. You can use 4,4'-dioxy-3, 3'-dimethyldiphenyl but also dissolve in a deficit of lye and add this solution to the one to be preserved Add material.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP13038A DE800877C (en) | 1948-10-02 | 1948-10-02 | Disinfectants and preservatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP13038A DE800877C (en) | 1948-10-02 | 1948-10-02 | Disinfectants and preservatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE800877C true DE800877C (en) | 1950-12-11 |
Family
ID=7364403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEP13038A Expired DE800877C (en) | 1948-10-02 | 1948-10-02 | Disinfectants and preservatives |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE800877C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE945950C (en) * | 1952-06-21 | 1956-07-19 | Bayer Ag | Protective agent with a fungicidal and bactericidal effect |
-
1948
- 1948-10-02 DE DEP13038A patent/DE800877C/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE945950C (en) * | 1952-06-21 | 1956-07-19 | Bayer Ag | Protective agent with a fungicidal and bactericidal effect |
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