DE722872C - Process for the preparation of an agent against foot and mouth disease - Google Patents
Process for the preparation of an agent against foot and mouth diseaseInfo
- Publication number
- DE722872C DE722872C DEH165503D DEH0165503D DE722872C DE 722872 C DE722872 C DE 722872C DE H165503 D DEH165503 D DE H165503D DE H0165503 D DEH0165503 D DE H0165503D DE 722872 C DE722872 C DE 722872C
- Authority
- DE
- Germany
- Prior art keywords
- mouth disease
- preparation
- distillation
- agent against
- against foot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 7
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 title claims description 5
- 241000710198 Foot-and-mouth disease virus Species 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title claims description 3
- 210000004369 blood Anatomy 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 10
- 238000004821 distillation Methods 0.000 claims description 7
- 210000002966 serum Anatomy 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 5
- 239000012153 distilled water Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000000502 dialysis Methods 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 241000700605 Viruses Species 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011088 parchment paper Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1009—Picornaviridae, e.g. hepatitis A virus
Description
Verfahren zur Herstellung eines Mittels gegen Maul- und Klauenseuche Bis jetzt hat man den Erreger der -Maul-und Klauenseuche noch nicht identifiziert und auch ein unfehlbares Mittel gegen diese gefürchtete Krankheit nicht gefunden. Im allgemeinen wird angenommen, daßi ein Virus der Erreger dieser Krankheit ist. Ferner ist es bekannt, daß Rekonvaleszentenblut in einzelnen Fällen bei subkutaner Injektion eine mehr oder weniger klare Verbesserung bei kranken Rindern verursachen kann.Process for the preparation of an agent against foot and mouth disease The pathogen causing foot-and-mouth disease has not yet been identified and an infallible remedy for this dreaded disease has not been found either. It is generally believed that a virus causes this disease. It is also known that convalescent blood in individual cases in subcutaneous Injection can cause a more or less clear improvement in sick cattle can.
Überraschenderweise hat sich nun gezeigt, daß aus Rekonvaleszentenblut oder Serum ein Stoff gewonnen werden kann, welcher bei intravenöser Injektion gesunde Rinder und Ferkel gegen Maul- und Klauenseuche schützen kann, selbst wenn diese Tiere längere Zeit in den gleichen Ställen mit kranken Tieren verbleiben. Das Mittel nach der Erfindung wirkt also prophylaktisch, im Anfangsstadium der Krankheit jedoch auch als Heilmittel.Surprisingly, it has now been shown that from convalescent blood or serum, a substance can be obtained which is healthy upon intravenous injection Can protect cattle and piglets against foot and mouth disease, even if they do Animals remain in the same stalls with sick animals for a longer period of time. The middle according to the invention therefore acts prophylactically, but in the initial stage of the disease also as a remedy.
Das neue Mittel wird hergestellt, indem man Rekonvaleszentenblut oder Serum einer Destillation unterwirft bzw. warme Luft hindurchführt und das Destillat bzw. die flüchtigen Stoffe z. B_ . in destilliertem Wasser auffängt.The new compound is made by taking convalescent blood or Serum is subjected to a distillation or warm air is passed through and the distillate or the volatile substances z. B_. in distilled water.
Die Wassermenge, in welcher man das Destillat aufnimmt, wird der Menge des zu destillierenden Bluts oder Serums wie auch der erwünschten Konzentration angepaßt.The amount of water in which the distillate is absorbed becomes the amount of the blood or serum to be distilled as well as the desired concentration customized.
Man kann auch so verfahren, daß, die Destillation unter vermindertem Druck unterhalb 7o° ausgeführt wird.You can also proceed in such a way that the distillation under reduced Pressure is carried out below 70 °.
Hierdurch wird der Vorteil erreicht, daß keine oder nur schwache Koagulation auftritt. Die Destillation bei höherer Temperatur führt nämlich unter Umständen zu Schwierigkeiten infolge der Erstarrung der Eiweiße. Den gleichen Vorteil erzielt man, wenn man warme Luft durch das Blut oder Serum hindurchführt, wobei man die Temperatur unterhalb 7o` hält.This has the advantage that no or only weak coagulation occurs. The distillation at a higher temperature may lead to certain circumstances to difficulties as a result of the solidification of the proteins. Got the same benefit when warm air is passed through the blood or serum, the Keeps temperature below 7o`.
Es ist festgestellt worden, daß, die heilende oder prophylaktische Wirkung abnimmt, wenn das Blut oder Serum der rekonvaleszenten Tiere nicht- bei niedriger Temperatur aufbewahrt wird: Noch bessere Erfolge werden erzielt, wenn man die Eiweißstoffe vor der Destillation völlig oder teilweise entfernt. Die Entfernung der Eiweiße kann in verschiedener Weise stattfinden, z. B. durch Fällung, vorzugsweise durch Dialyse. -Das Blut oder Serum wird in ein Gefäß gebracht und dann mit Pergamentpapier dialysiert. Als Dialysierflüssigkeit verwendet man vorzugsweise destilliertes Wasser. Dabei gehen die gelösten bzw. löslichen Stoffe in das destillierte Wasser über, während die Eiweiße u. dgl. zurückbleiben.It has been found to be curative or prophylactic Effect decreases when the blood or serum of the convalescent animals is not stored at low temperature: Even better results are achieved, if the proteins are completely or partially removed before the distillation. the Removal of the proteins can take place in various ways, e.g. B. by precipitation, preferably by dialysis. -The blood or serum is placed in a vessel and then dialyzed with parchment paper. The dialysis fluid used is preferably distilled water. The dissolved or soluble substances go into the distilled one Water over while the proteins and the like remain.
Die erhaltene wäßrige Lösung wird nun gegebenenfalls unter Druckverminderung destilliert. Man kann auch die vor oder während der Erwärmung entstehenden Dampf-oder Gasbläschen in einem vorigen Destillat auffangen.The aqueous solution obtained is then optionally reduced in pressure distilled. One can also use the steam or steam produced before or during the heating Collect gas bubbles in a previous distillate.
Zur Erläuterung des Verfahrens nach der Erfindung wird folgendes Ausführungsbeispiel gegeben: 21 Blut werden mit 35o cms destilliertem Wasser bei Zimmertemperatur und normalem Luftdruck dialysiert. Nach 15 Stunden wird die Flüssigkeit destilliert, bis ungefähr die Hälfte übergegangen ist. Das Destillat wird in r o cm l destillierten Wassers oder eines vorigen Destillats aufgefangen.The following exemplary embodiment is used to explain the method according to the invention given: 21 blood are mixed with 35o cms of distilled water at room temperature and dialyzed at normal air pressure. After 15 hours the liquid is distilled, until about half is passed. The distillate is distilled in r o cm l Water or a previous distillate.
Das Ausgangsblut wird 8 bis 1.1 Tage nach Ausbruch der Krankheit den Tieren entnommen. "Die Menge des zu injizierenden 1littels beträgt z. B. 6o cm@. Die Injektion wird nicht wiederholt.The starting blood is removed from 8 to 1.1 days after the onset of the disease Taken from animals. "The amount of the drug to be injected is, for example, 60 cm @. The injection is not repeated.
Claims (3)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL722872X | 1939-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE722872C true DE722872C (en) | 1942-07-28 |
Family
ID=19817697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEH165503D Expired DE722872C (en) | 1939-10-16 | 1941-05-29 | Process for the preparation of an agent against foot and mouth disease |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE722872C (en) |
-
1941
- 1941-05-29 DE DEH165503D patent/DE722872C/en not_active Expired
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